PLoS ONE
Articles in this Issue
Yaws active case detection surveys in 15 districts of Cote d’Ivoire
Background Yaws is one of the skin-related neglected tropical disease (skin NTD). It is closely linked to poverty and occurs mainly in poor communities in hot, humid, tropical regi...
Effectiveness of virtual clinical simulation in palliative care education for nursing students: Protocol of a randomized controlled trial
Background Palliative care often involves nursing for complex patient groups at the end of life, which requires specialized knowledge and ethical considerations. Therefore, it is f...
Cost-effectiveness of inclisiran in patients with atherosclerotic cardiovascular disease from Chinese healthcare perspective
Background Atherosclerotic cardiovascular disease (ASCVD) imposes a substantial clinical and economic burden in China. Despite maximally tolerated statin therapy, many patients fai...
Physical activity and depressive symptoms among Chinese university students: Grit as a mediator
Background While physical activity is widely recognized for its protective role against depressive symptoms, the specific psychological mechanisms that explain this relationship, p...
Barriers and facilitators to implementing childcare in long-term care homes: A scoping review protocol and consultative exercise
Background Long-term care (LTC) homes face persistent workforce recruitment and retention challenges, particularly among staff balancing professional responsibilities with childcar...
Transformation of artistic style and innovative design of oriental folk patterns based on AIGC Technology—A case study of Zhuxian town new year paintings from China
In response to the limited cross-domain innovation in the digitalization of traditional oriental folk art, this study takes the New Year pictures of China’s Zhuxian Town as a case. It develops a colla...
Exploring the contribution of straw utilization to carbon emission reduction in Anhui Province (China)
Taking various prefecture-level cities in Anhui Province as the subject of this study, this research draws on data from the ‘Anhui Statistical Yearbook’ to analyze crop straw resources’ potential full...
Sterilization efficacy of a warm-air circulation system in a vaporized hydrogen peroxide sterilizer
Background Vaporized hydrogen peroxide (VH 2 O 2 ) sterilization is a...
Local genetic correlations between systemic sclerosis and common cancer types
Introduction The incidence of cancer, encompassing all major types, is significantly higher among patients with systemic sclerosis (SSc) compared to the general population. While p...
When Matilda shows up: The double-edged impact of women researchers’ media visibility in management science
Although the proportion of women in academic positions has increased, women researchers continue to receive less media coverage than their counterparts. To examine the implications of this underrepres...
Exploring the perceived impact of physical activity on physical and mental health among individuals with long COVID: A qualitative interview inquiry
Objectives Long COVID presents a significant health burden with limited treatment options. Physical activity (PA) has been suggested for self-management, yet symptom worsening has...
Motorization and its consequences: A mixed-methods study on the epidemiology, impact, and stakeholder perspectives of road traffic injuries among undergraduate two-wheeler riding students in Nepal
Introduction Motorization has undeniably enhanced mobility and convenience, but it comes at a significant cost, as the increasing number of vehicles has led to a surge in road traf...
A portable, ultra-low cost, open-source, pedal-controlled microinjector for laboratory use
In vivo transduction or electroporation often requires sub-microliter volume injection of virus or recombinant DNA/RNA to a precise anatomic site. Two-hand manual manipulation of t...
Limited and idiosyncratic thermal acclimation in soil saprotrophic fungi
Increased soil microbial activity due to higher temperatures caused by heatwaves could lead to higher carbon losses from soil into the atmosphere, further accelerating climate change. Hence, knowing h...
Distribution of refractive errors and horizontal concomitant strabismus in Iraqi children
Horizontal concomitant strabismus is a common pediatric ocular disorder influenced by underlying refractive error patterns, yet evidence from Iraq remains limited. This study characterized refractive...
Histological and metagenomic analysis of microbial communities in archaeological human bones
Buried archaeological bones tend to be heavily degraded by microorganisms. This type of biodegradation was already identified in the 19 th century and remains a...
Early tumour size changes from neoadjuvant chemotherapy as a predictor of pathologic response in breast cancer
Neoadjuvant chemotherapy (NAC) is the standard of care for locally advanced, human epidermal growth factor receptor 2-positive, and triple negative breast cancer. While complete pathologic response is...
Mycoplasma penetrans methionyl-tRNA synthetase dimerizes via tandem N-terminal ancillary domains
Diverse aminoacyl-tRNA synthetase gene fusions are now recognized as a common mechanism for enhancing genetic diversity across all domains of life. The metS gen...
Coping strategies and perceived burden among caregivers of frail elderly with mental disorders attending teaching hospital: A cross-sectional study
Caregivers of frail elderly with mental illness undergo various practical problems, however, adaptive coping skills help to reduce perceived caregiver burden. This study aimed to identify the coping s...
Regional trends and forecasting of under-five child mortality in Bangladesh: A mixed method approach of Functional ANOVA and Bayesian spatiotemporal modeling
Background This study aims to estimate historical under-five mortality rates from 1990 to 2022 across the eight divisions of Bangladesh, analyze regional disparities, and forecast...
Editorial Note: Host-Associated Metagenomics: A Guide to Generating Infectious RNA Viromes
Risk assessment of civil aviation cabin safety incidents based on the CNN–LSTM–Attention model
Against the backdrop of the thriving global civil aviation industry, cabin safety, which is a crucial link in civil aviation safety systems, has prompted an increasingly urgent need for intelligent ri...
Advancing poultry health: A meta-analysis of epitope-based and peptide-based vaccines against Avian Pathogenic E. coli with machine learning insights
Introduction Avian Pathogenic Escherichia coli (APEC) causes colibacillosis in poultry, which leads to tremendous...
Seismic fragility analysis of fully prefabricated frame structures with steel plate hoop bolt connections based on various engineering demand parameters
Steel plates and bolted connections have become common construction details in prefabricated structural systems. However, prefabricated frame structures with steel plate hoop–bolted connections exhibi...
Repeated dosing of myrrh, chamomile extract, and coffee charcoal reveals potential health-beneficial effects in patients with irritable bowel syndrome in the M-SHIME simulator
Objective To define the potential functional roles of a herbal preparation of myrrh, chamomile extract, and coffee charcoal in patients suffering from diarrhea dominant irritable b...