PLoS ONE
Articles in this Issue
Tissue scaffold architecture affects implant degradation and bone tissue regeneration: A novel in silico mechanobiological model analysing cell behavior, mechanical stress and degradation kinematics
Synthetic bone tissue scaffold function is controlled by both material and architecture. Experimental biomaterial approaches have brought significant advances in scaffold function, but scaffold archit...
Anti-inflammatory and immunomodulatory potential of lignans from Artemisia cina: Integrated quantum, docking, and cytokine expression studies
Quantum, docking, and in vitro studies were performed to evaluate the immunomodulatory function of two lignans isolated from Artemisia cina...
Accuracy of sarcopenia screening tools among older adults with stroke undergoing inpatient rehabilitation
Background Appropriate screening tools for sarcopenia are available for older adults with stroke undergoing inpatient rehabilitation, however how well these tools predict and event...
Photobiomodulation for pain management during placement of the copper T 380 intrauterine device: Protocol for a randomized, double-blind controlled trial
Introduction Unplanned pregnancy remains a critical public health issue in Brazil that affects up to 65% of women in some regions and increases the incidence of both unsafe abortio...
Knowledge, attitude, and practice about e-cigarettes among university students: A comparative study between Afghanistan, the Netherlands, and Turkey
Background The rise in e-cigarette use among young adults has raised significant public health concerns. Initially introduced as a harm-reduction tool, e-cigarettes have increasing...
Retraction: Digital economy, scientific and technological innovation, and high-quality economic development: A mediating effect model based on the spatial perspective
Expression of Concern: Economic policy uncertainty, intra-industry trade, and China’s mechanical and electrical product exports
‘The world is just so fast, and I’m not fast… it’s just really, really difficult to keep up’: A qualitative exploration of the lived experience of adults with Developmental Coordination Disorder
Background Developmental Coordination Disorder (DCD) is an under-recognised neurodevelopmental condition impacting 5–6% of the population. There is a growing evidence base showing...
Impact of depression and anxiety on health-related quality of life changes over time within individuals with rheumatoid arthritis or inflammatory bowel disease: A prospective Canadian cohort study
Objectives In individuals with rheumatoid arthritis (RA), inflammatory bowel disease (IBD), or primary depressive or anxiety disorders without RA or IBD (DEP/ANX) we aimed to evalu...
Biaxial strength under fatigue of 4YSZ: Surface treatment and resin cement viscosity effects
This study aimed to investigate the effect of different surface treatments combined with high- or low-viscosity resin cements on the biaxial flexural strength of 4YSZ ceramics. Discs of 4YSZ (IPS e.ma...
UAV-based RGB and multispectral mango leaf disease detection with benchmarking of YOLOv5 to YOLOv10 and SeqOpt-optimised YOLOv8 for real-time edge deployment
The article presents a real-time mango leaf disease detection framework with embedded edge deployment, using UAV-based multispectral imaging combined with optimised deep learning models. A custom data...
COVID-19 pandemic-related stress and substance use behaviors among people with HIV – a mixed method analysis
Background Stress and financial concerns due to the COVID-19 pandemic are well documented, with mixed evidence regarding their relationship with substance use. This mixed-methods s...
In vitro dissolution and release kinetics of multisource ciprofloxacin 500 mg tablets in West Gondar, Ethiopia: Implications for interchangeability and regulatory oversight
Background In vitro dissolution is a critical quality control test in pharmaceutical development, used to measure the rate and extent a...
Editorial Note: Re-use of laboratory utensils reduces CO2 equivalent footprint and running costs
Validating hip- and wrist-ActiGraph accelerometer cut-points for physical activity intensities in people living with coronary heart disease
People with coronary heart disease (CHD) are encouraged to meet the public health moderate-to-vigorous aerobic physical activity (MVPA) guidelines for secondary prevention of cardiovascular disease. H...
Effect of digitizing Community Health Information System on the delivery and use of maternal and child health services: Propensity score matching analysis
Introduction In 2018, Ethiopia’s government digitized its Community Health Information System (eCHIS) to enhance Health Extension Program service delivery. However, the impact of e...
Long-term rapamycin treatment suppresses IL-17-producing gamma delta T cells and blunts neuroinflammation in aging
Aging is the gradual accumulation of structural and functional changes in an organism over time, including immune remodeling and a progressive increase in basal inflammation, or inflammaging. The mTOR...
Validation and utility of the French version of the Unified Multidimensional Calling Scale (UMCS-22) for stipended volunteer firefighters
This study evaluated the psychometric properties of the French version of the Unified Multidimensional Calling Scale (UMCS-22), adapted for use with volunteer firefighters, including reliability, cons...
Correction: Clay minerals evidences for cold-warm fluctuations in the early Silurian
Serological responses to SARS-CoV-2 in urban and rural Ghana: Antibody waning and implications for long-term population immunity
Background Ghana exhibits geographic variation across northern and southern regions alongside differences between urban and rural communities, which may influence SARS-CoV-2 exposu...
Curiosity in calamity: How personal schadenfreude shapes disaster-tourism intentions
Tourism to sites of recent disaster, a form of dark tourism has raised questions about whether visitors are driven by typical travel motivations or by morbid impulses. This study examines how conventi...
Building breastfeeding knowledgeable health systems: Focus groups with physician leaders
Despite the growth of breastfeeding and lactation medicine as a specialty, the care of breastfeeding families is compromised because few standards and recommendations exist for its practice and integr...
Physiologic and molecular response of Fusarium oxysporum f. sp. zingiberi to ginger autotoxins
Long-term monoculture of ginger triggers Fusarium wilt, a disease caused by Fusarium oxysporum f. sp....
Hemodynamic impact of blood viscosity in intracranial atherosclerotic arteries with varying stenosis severity: A non-newtonian computational fluid dynamics patient specific study
Intracranial atherosclerotic stenosis (ICAS) is a major cause of ischemic stroke, yet geometric stenosis alone may not fully reflect the functional hemodynamic burden of a lesion. This study used comp...
Multimerization interactions between protein-inspired single-chain random heteropolymers
Single-chain nanoparticles (SCNPs) are attractive for their ability to interact with or behave akin to native proteins. In this work, we use molecular dynamics simulations to examine how SCNPs which a...