PLoS ONE
Articles in this Issue
Association of urinary post-translationally modified fetuin-A fragments with diabetic kidney disease risk stratification in Japanese patients with type 2 diabetes
Aims Conventional biomarkers such as estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (uACR) primarily reflect glomerular damage and often fail t...
Toward evidence-based prescription of prosthetic ankle-foot devices: A multisite randomized crossover trial identifying performance-based, patient-reported, and biomechanical parameters sensitive to device type
Prescription of prosthetic ankle-foot devices is constrained by imprecise clinical guidelines and inconsistent scientific evidence, hindering optimal device selection for individuals with lower limb l...
OncoSeg2D: A deep framework for semantic segmentation of lung cancer in 2D CT scans
Lung cancer lesion segmentation in two-dimensional computed tomography (2D CT) images remains challenging due to blurred boundaries, heterogeneous morphologies, and annotation uncertainty, leading to...
Spontaneous passage of common bile duct stones: predictive factors and impact on post-ERCP complications
Background Spontaneous passage of common bile duct stones (CBDSs) may render endoscopic retrograde cholangiopancreatography (ERCP) unnecessary. Although predictors of passage have...
Insomnia and poor sleep quality in refugee and asylum-seeking populations: A systematic review and meta-analysis
Refugees and asylum seekers face significant mental health challenges, yet sleep disturbances remain underrecognized despite their critical impact on well-being. This systematic review and meta-analys...
Evaluation of anemia in non-enhanced and contrast-enhanced dual-energy CT using electron density imaging
Electron density (ED) imaging derived from dual-energy CT (DECT) quantifies tissue composition and may reflect changes in red blood cell (RBC) mass associated with anemia. This study aimed to evaluate...
Imaging of cervicothoracic junction anatomical variation in neurogenic thoracic outlet syndrome: A scoping review protocol
Objective The objective of this scoping review is to systematically map the extent and nature of the literature on the use of imaging for assessing cervicothoracic junction anatomi...
ICG fluorescence imaging-guided bile leak detection to reduce clinically relevant bile leakage after hepatectomy: A protocol for a systematic review and meta-analysis
Background Bile leakage remains a clinically relevant complication after hepatectomy and contributes to morbidity, prolonged drainage, extended hospital stay, and the need for rein...
Growth monitoring and promotion uptake and its associated factors among mothers/ caregivers of children aged under two years in Wondo District, Ethiopia: Cross-sectional Study
Introduction Growth monitoring and promotion (GMP) can be used to address developmental halting before a child’s health deteriorates. However, there hasn’t been much research done...
Protocol for the SACLA trial: Efficacy and safety of subretinal monteplase for submacular hemorrhage in a phase II single-arm multicenter decentralized clinical trial
Submacular hemorrhage (SMH), which may arise from age-related macular degeneration, retinal arterial macroaneurysm, and other causes, can result in severe vision loss and central visual field impairme...
Deep learning based two-way feature depiction model for brain tumor detection
Brain tumors are one of the most fatal disorders that cause one of the highest mortalities in the world. Gliomas are the most common primary brain tumors originating from glial cells in the central ne...
Music-induced cortical plasticity: Protocol for a systematic review
Music engages sensory, motor, cognitive, and emotional systems, making it a powerful model for studying experience-dependent neuroplasticity. Although research on music-related brain changes is expand...
Calculation method and predictive analysis of flexural capacity of reinforced concrete beams strengthened with carbon fiber-reinforced polymer sheets applied to the side surfaces
In response to the situation where it is not allowed to stick CFRP cloth at the bottom of a concrete beam and stick it on both sides of the beam, this article analyzes the factors that affect the ulti...
Editorial Note: Expression and function of the miR-143/145 cluster in vitro and in vivo in human breast cancer
A-eye: Automated 3D MRI segmentation and morphometric feature extraction for eye and orbit atlas construction
In this study we introduce automated 3D segmentation of the healthy human adult eye and orbit from Magnetic Resonance Images, to improve ophthalmic diagnostics and treatments. Past efforts have primar...
NOX2 inhibition attenuates oxidative stress and eNOS uncoupling in pulmonary arteries of rats following simulated air diving
Simulated diving and decompression can impair endothelial function, but the upstream oxidant sources and their relationship with endothelial nitric oxide synthase (eNOS) coupling in the pulmonary circ...
Expression of Concern: Investigations on segmentation-based fractal texture for texture classification in the presence of Gaussian noise
Gold wrist-assisted PFNA reduces internal complications and enhances recovery in obese osteoporotic patients with intertrochanteric femur fractures
Introduction Obese, osteoporotic patients with intertrochanteric fractures face higher surgical risks and delayed recovery. The “Gold Wrist,” an auxiliary curved guiding instrument...
Spatio-temporal patterns and prediction of colorectal cancer mortality in Chinese cancer registration areas: A nationwide study based on multiple models
Objective To describe the spatiotemporal distribution characteristics of colorectal cancer (CRC) mortality in Chinese cancer registration areas and to predict its future trends, th...
ClpP deficiency attenuates contrast-induced HK-2 cell injury through changes associated with mitochondrial dynamics and apoptosis
Background Contrast-associated acute kidney injury (CA-AKI) is a renal impairment that occurs after several days of intravascular administration of iodine-containing contrast media...
Effects of ginger-loaded chitosan nanoparticles on growth, morphological and biochemical attributes of Sesamum indicum L.
Chitosan nanoparticles (ChNPs) have gained attention due to their biodegradability, biocompatibility, and non-toxicity, and are found in a wide range of agricultural products. The green synthesis and...
COMBINA: The EAAD four-level approach for depression and suicide prevention and wellbeing promotion in the community and vulnerable populations. A cross-country study protocol from the MENTBEST project
Depression and suicide are leading public health problems requiring complex multilevel interventions. This study protocol details the COMBINA trial, which expands the evidence-based European Alliance...
Action-guilt, survivor-guilt, and depression in combat-related PTSD
Identifying the role of guilt in post-traumatic stress disorder (PTSD) has important implications for understanding the development and treatment of PTSD. The present study is a secondary analysis of...
Biogenic Silver–Selenium nanocomposite with anticancer activity and potent efficacy against vancomycin-resistant Staphylococcus aureus
The rapid emergence of multi-drug resistant (MDR) pathogenic bacteria as well as the continued burden of malignant diseases requires the safe development of novel and multifunctional therapeutic agent...
Key molecular mechanisms of mitochondrial metabolic pathways in specific cell subpopulations of pancreatic cancer based on scRNA-seq and bulk RNA-seq
Background Pancreatic cancer (PC) is a highly malignant tumor with increasing incidence, mortality, and a low five-year survival rate. Mitochondrial metabolic reprogramming plays a...