PLoS ONE
Articles in this Issue
Eligibility to donate blood under an individual donor assessment policy: A national cross-sectional study of gay, bisexual and other men who have sex with men in Aotearoa, New Zealand
Background To protect the blood supply, many countries defer higher-risk donors such as men who have had sex with men (MSM) in the last 3 months. However, this may be unnecessarily...
Cognitive flexibility, impulsivity, and compulsivity in problematic consumption behaviours
Different studies have identified cognitive inflexibility, impulsivity and compulsivity in substance use and gambling disorder, but it is unclear whether these deficits are present in other possible a...
Global lung cancer burden, trends, and projections from 2010 to 2050: A population-level severity framework integrating DALYs-per-case and mortality-to-incidence ratio
Background Lung cancer remains the leading cause of cancer mortality worldwide. While incidence and mortality describe population burden, they do not fully capture disease severity...
Completeness of death registration in Ghana: An evaluation of multiple data sources and methods
Introduction The lack of a robust and comprehensive civil registration system undermines efforts to develop policies that address emerging health issues in a population. While Ghan...
Expression of Concern: How does social support influence autonomous physical learning in adolescents? Evidence from a chain mediation and latent profile analysis
Influence of salinity on growth, nutrient utilization, and gene expression of giant freshwater prawn (Macrobrachium rosenbergii)
Salinity is one of the most influential eco-hydrological factors that affect the molting, growth, and other physico-biochemical responses of crustaceans. A 56-day in vivo experiment was conducted to a...
Cardiometabolic risk pathways in adults with disabilities: A structural equation model of diet quality and functional ability
Background Adults with disabilities experience increased cardiometabolic risk, yet the pathways linking nutrition, functional ability, and environmental factors remain insufficient...
HLA-DRB1 and HLA-DQB1 genetic polymorphisms and susceptibility to coronary atherosclerosis in a Northeast Chinese Population: A case-control study
Atherosclerosis is a chronic inflammatory disease with increasing prevalence in Northeast China, where HLA class II molecules play an important immunoregulatory role. However, the contribution of spec...
Balancing adaptations and fidelity of implementation strategies to optimize primary healthcare in Ethiopia: Lessons from embedded implementation research
Background Optimizing Ethiopia’s Health Extension Program (HEP) has been critical to enhancing primary healthcare (PHC) service delivery, particularly in remote and underserved set...
Cone photoreceptor ablation in microglia-deficient larval zebrafish retina elicits a regenerative response alongside a compensatory immune cell response
Emerging evidence implicates retinal microglia and inflammation as important components impacting the outcome of retinal regeneration, which is spontaneously achieved in zebrafish retina following acu...
Evaluation of outcomes in 201 child and youth survivors of Child Sexual Abuse (CSA) who participated in a one-year multimodal treatment program
Background and rationale Child sexual abuse (CSA) is a pervasive and prevalent form of early-life trauma that can increase the risk for PTSD, mood disorders, substance abuse, harmf...
Trends in general practitioner dispensing of thickeners in the NHS England, 2019–24
Introduction Oropharyngeal dysphagia is common and often results in aspiration. Thickeners are widely used to thicken liquids to slow the liquid bolus and prevent aspiration and as...
Parents’ role as advocates for and against childhood vaccination: Findings from a nationally representative survey
Introduction In 2025, the US recorded the highest number of measles cases in 25 years, signaling an urgent need for renewed attention to increasing childhood vaccination coverage....
Efficacy and limitations of diffusion-weighted imaging with background suppression-based whole-body magnetic resonance imaging in high-risk prostate cancer staging: A retrospective study
Purpose To evaluate the diagnostic performance and limitations of whole-body magnetic resonance imaging (WB-MRI) using diffusion-weighted imaging with background body signal suppre...
Service-oriented cloud manufacturing systems: Balancing profit, customer satisfaction, and resource fairness
The rapid growth of customized demand and geographically distributed manufacturing resources has increased the need for integrated decision-making in cloud manufacturing systems. In such environments,...
A decade of progress and challenges in Water, Sanitation and Hygiene (WASH) coverage in Bangladesh: Insights from Bangladesh demographic and health survey 2011–2022
Background Access to safe water, sanitation, and hygiene (WASH) remains a critical global public health challenge, with an estimated 2 billion people lacking safe drinking water an...
5-Fluorouracil modulates motility and biofilm-associated gene expression in Pseudomonas aeruginosa
Pseudomonas aeruginosa is an opportunistic pathogen in which motility, biofilm formation, and stress adaptation contribute to virulence. Drug repurposing represents a practical str...
Counting missing babies in Tanzania: Neonatal mortality data quality from Tanzania’s District Health Information System across 28 Regional and 7 Tertiary hospitals (2015–2024)
Introduction The Sustainable Development Goal 3.2 targets reducing the neonatal mortality rate (NMR) to <12 per 1,000 live births by 2030; however, 65 countries, including Tanza...
Evaluation of forage oat cultivars for alpine saline-alkaline environments: Trade-offs between yield, quality and stability
Oat cultivation in the alpine saline-alkaline Qaidam Basin requires cultivars that balance yield, quality, and stability. Identifying suitable cultivars is key to sustainable forage production. Three...
Video summarization based on multi-scale feature fusion
Video summarization aims to identify the important segments of a video and form a concise representation, enabling users to quickly grasp the core information. Existing graph-based video summarization...
Dose-response relationships of sensorimotor-based interventions on balance performance in older adults: A systematic review and meta-regression analysis
Falls are a severe public health challenge for older adults. Although sensorimotor-based interventions can remodel balance, their quantitative dose-response trajectories remain unknown, often leading...
Cardiorespiratory fitness profile of volunteer firefighters during intermittent incremental exercise: A cross-sectional study
Purpose We aimed to assess the physiological profile of male volunteer firefighters at a broad spectrum of exercise intensities to determine whether their cardiorespiratory fitness...
Identify perceived strategies for promoting happiness among nurses: Protocol for a mixed-methods study
Background Enjoyment at work and overall happiness are essential elements of a thriving workforce, particularly in high-pressure environments like healthcare. Nurses frequently exp...
Lipid-modifying pharmacotherapy in diabetes mellitus: A protocol for a systematic review and network meta-analysis of randomised trials
Introduction The global prevalence of diabetes mellitus (DM) has risen markedly, with patients facing a substantially higher risk of atherosclerotic cardiovascular disease (ASCVD)...
Safety profile of camrelizumab: An analysis based on literature and database review
Objective Real-world studies on the safety of camrelizumab are scarce. This study aimed to investigate the adverse drug reactions (ADRs) associated with camrelizumab and evaluate t...