PLoS ONE
Articles in this Issue
Novel methotrexate long-acting system using ambroxol coating and hydroxypropyl methylcellulose encapsulation for preferential and enhanced lung cancer efficiency
Methotrexate (MTX) is classified as an antimetabolite. It’s commonly used to treat lung cancer. MTX is an immunosuppressant following the above-mentioned mechanism of action due to its poor selectivit...
Household food insecurity, living conditions, and individual sense of security: A cross-sectional survey among Burkina Faso refugees in Ghana
Food insecurity and achieving adequate nutrition is a major global challenge, especially in vulnerable groups such as refugee communities. In West Africa, thousands of Burkina Faso refugees have cross...
Integrating post-validation surveillance of lymphatic filariasis with the WHO STEPwise approach to non-communicable disease risk factor surveillance in Niue, a study protocol
Background Lymphatic filariasis (LF), a mosquito-borne parasitic disease caused by three species of filarial worms, was first detected in Niue, a small Pacific Island nation of app...
Spatial epidemiological analysis based on township scale and analysis of influencing factors of pulmonary tuberculosis cure of Changshu city from 2015 to 2022
Objective This study aimed to enhance the prevention and control of pulmonary tuberculosis (PTB) and provide more effective and accurate methods in Changshu City. Methods The PTB patients’ informati...
Analysis of entropy on the European markets of energy and energy commodities prices
The paper analyzes the problem of entropy in the moments of transition from a normal economic situation (2015–2019) to the Pandemic period (2020–2021) and the period of Russia’s attack on Ukraine (202...
Correction: Genetic polymorphisms of muscular fitness in young healthy men
Long-term health consequences and costs of changes in alcohol consumption in England during the COVID-19 pandemic
Background and aims The COVID-19 pandemic led to changes in alcohol consumption in England. Evidence suggests that one-fifth to one-third of adults increased their alcohol consumption, while a similar...
Factors associated with knowledge and practice regarding oxygen administration: A cross-sectional study among registered nurses working in wards and ICUs at Muhimbili National Hospital in Dar es Salaam, Tanzania
Background Oxygen is a vital therapy approved by WHO, crucial for critically ill patients as a supplemental treatment. Nurses’ pivotal role in oxygen administration is poorly understood. This study ai...
Factors associated with quality of life of chronic spontaneous urticaria patients in a Vietnamese population
Objective Chronic spontaneous urticaria (CSU) is a challenging condition that significantly impacts the affected patients. This study aimed to evaluate the quality of life (QoL) among patients with CS...
Cellular senescence-associated genes in rheumatoid arthritis: Identification and functional analysis
Rheumatoid arthritis (RA), a long-term autoinflammatory condition causing joint damage and deformities, involves a multifaceted pathogenesis with genetic, epigenetic, and immune factors, including ear...
The gender gap in STEM: (Female) teenagers’ ICT skills and subsequent career paths
Skills shortage in the fields of Sciences, Technology, Engineering, and Mathematics (STEM) poses a significant challenge for industries globally. To overcome shortage of STEM talent, the selection int...
Single-cell and bulk RNA sequencing analysis reveals CENPA as a potential biomarker and therapeutic target in cancers
Background Cancer remains one of the most significant public health challenges worldwide. A widely recognized hallmark of cancer is the ability to sustain proliferative signaling, which is closely tie...
The diagnostic accuracy of umbilical cord procalcitonin in predicting early-onset neonatal infection
Introduction To determine the threshold of umbilical cord blood procalcitonin for early-onset neonatal infection diagnosis. Method This prospective study was conducted on 126 neonates in the neonata...
A facial expression recognition network using hybrid feature extraction
Facial expression recognition faces great challenges due to factors such as face similarity, image quality, and age variation. Although various existing end-to-end Convolutional Neural Network (CNN) a...
Beyond burnout: A comprehensive investigation of burnout, resilience, and career continuity among Palestinian lawyers in a complex socio-political environment
This article investigates burnout among lawyers and proposes systemic changes to reduce pressure and stress in the legal profession while enhancing resilience among lawyers. The article focuses on fac...
Parental experience of change following VIPP-SD in families with preschool children with externalizing behavior: A qualitative interview study
Background Insensitive parenting and ineffective disciplinary strategies are known risk factors for child externalizing behavior. The Video-feedback Intervention to promote Positive Parenting and Sens...
Non-linear dose-response relationship between uterine artery pulsatility index and risk of preeclampsia in early pregnancy: A secondary analysis based on a nested cohort study
Background Previous studies have shown that higher uterine artery pulsatility index (UtA-PI) values in early pregnancy have predictive value for the risk of preeclampsia (PE). However, the sensitivity...
Difference-Cum-Exponential-type estimators for estimation of finite population mean in survey sampling
Extensive research work has been done for the estimation of population mean using bivariate auxiliary information based on conventional measures. Conventional measures of the auxiliary variables provi...
Ontology-based construction of embroidery intangible cultural heritage knowledge graph: A case study of Qingyang sachets
The fine-grained mining and construction of semantic associations within multimodal intangible cultural heritage (ICH) resources are crucial for deepening our understanding of their knowledge content...
Coupling SAR and optical remote sensing data for soil moisture retrieval over dense vegetation covered areas
Soil moisture is a key parameter for the exchange of substance and energy at the land-air interface, timely and accurate acquisition of soil moisture is of great significance for drought monitoring, w...
Advancing semantic segmentation: Enhanced UNet algorithm with attention mechanism and deformable convolution
This paper presents a novel method for improving semantic segmentation performance in computer vision tasks. Our approach utilizes an enhanced UNet architecture that leverages an improved ResNet50 bac...
Looking back into the Hepatitis C Virus epidemic dynamics from Unnao, India through phylogenetic approach
Viral hepatitis is a major public health challenge. Hepatitis C Virus (HCV) infection causes the progressive liver damage. A surprisingly high number of individuals tested positive for HCV infection d...
Outcome comparison of rotational ankle fractures: Supination external rotation versus pronation external rotation
Background Ankle fractures are among the most common types of fractures in the orthopaedic field, and the Lauge-Hansen classification is commonly used to categorize rotational ankle fractures. This st...
CooccurrenceAffinity: An R package for computing a novel metric of affinity in co-occurrence data that corrects for pervasive errors in traditional indices
1. Analysis of co-occurrence data with traditional indices has led to many problems such as sensitivity of the indices to prevalence and the same value representing either a strong positive or strong...
Trends in the prevalence of obesity and estimation of the direct health costs attributable to child and adolescent obesity in Brazil from 2013 to 2022
Introduction Childhood obesity is a major global public health issue globally and in Brazil. The impacts of childhood obesity include higher risk of disease during childhood and of obesity and non-com...