PLoS ONE
Articles in this Issue
Identification of novel antiviral host factors by functional gene expression analysis using in vitro HBV infection assay systems
To cure hepatitis B virus (HBV) infection, it is essential to elucidate the function of hepatocyte host factors in regulating the viral life cycle. Signaling and transcription activator of transcripti...
Experiment and analysis on the heterogeneity of CO2 adsorption-transport by microrocks in coal matrix
In order to study gas adsorption performance effected by micro-rock in coal matrix, dual energy X-ray CT was used to calculate the density change of coal core before and after gas injection, which can...
Akt3 links mitochondrial function to the regulation of Aurora B and mitotic fidelity
Akt3 is a key regulator of mitochondrial homeostasis in the endothelium. Akt3 depletion results in mitochondrial dysfunction, decreased mitochondrial biogenesis, and decreased angiogenesis. Here we li...
Correction: Potential model of Scalesia pedunculata carbon sequestration through restoration efforts in agricultural fields of Galapagos
OM-VST: A video action recognition model based on optimized downsampling module combined with multi-scale feature fusion
Video classification, as an essential task in computer vision, aims to identify and label video content using computer technology automatically. However, the current mainstream video classification mo...
The impact of extended reality cognitive behavioral therapy on mental disorders among children and youth: A systematic review and meta-analysis protocol
Background The prevalence of mental disorders among children and youth has significantly increased, with rising rates of anxiety, depression, and other psychological disorders globally. Despite the wi...
Camera traps unable to determine whether plasticine models of caterpillars reliably measure bird predation
Sampling methods that are both scientifically rigorous and ethical are cornerstones of any experimental biological research. Since its introduction 30 years ago, the method of using plasticine prey to...
The integration of health equity into policy to reduce disparities: Lessons from California during the COVID-19 pandemic
Racial and ethnic minoritized groups and socioeconomically disadvantaged communities experience longstanding health-related disparities in the United States and were disproportionately affected throug...
Genetic diversity and population structure of Ethiopian Sweet Sorghum [Sorghum bicolor (L.) Moench] germplasms using SSR markers
Sweet sorghum is a cereal crop in the grass family belonging to the genus Sorghum bicolor L. Moench. It is known in its sugary juice that is accumulated in its stalk and efficient C4 photosynthetic pa...
Implementing a new patient navigator model of care within the emergency department for older adults in Ontario, Canada
A Patient Navigator (PN) role was introduced in the Emergency Department (ED) in a large metropolitan hospital in Southern Ontario (Canada) to assist with care transitions. The purpose of this study w...
A novel oncolytic vaccinia virus with multiple gene modifications involved in viral replication and maturation increases safety for intravenous administration while maintaining proliferative potential in cancer cells
To generate a novel oncolytic vaccinia virus with improved safety and productivity, the genome of smallpox vaccine strain LC16m8 was modified by a bacterial artificial chromosome system. By using LC16...
The effect of IL-1β inhibitor canakinumab (Ilaris®) on IL-6 production in human skeletal muscle cells
Muscle inflammation is one of the hallmarks of Duchenne muscular dystrophy (DMD). Dystrophin-deficient skeletal muscle cells produce higher levels of pro-inflammatory cytokines such as interleukin 1β...
Dealing with radiation risks in systemic cancer treatment: Perspectives of practitioners and patients in French hospitals
Systemic radionuclide therapy (SRT) using substances such as 177Lu is an approach in cancer treatment that aims to destroy malign tissues by injecting radionuclides directly into patients’ bodies via...
Conservative endometrioma surgery: The combined technique versus CO2-laser vaporization only (BLAST: Belgium LAser STudy): Clinical protocol for a multicenter randomized controlled trial
Background The surgical management of endometrioma(s) remains challenging. Although laparoscopic surgery is a well-established treatment of endometrioma(s), caution is required to minimize ovarian da...
Prediction of drug target interaction based on under sampling strategy and random forest algorithm
Drug target interactions (DTIs) play a crucial role in drug discovery and development. The prediction of DTIs based on computational method can effectively assist the experimental techniques for DTIs...
Mapping the value of commercial fishing and potential costs of offshore wind energy on the U.S: West Coast: Towards an assessment of resource use tradeoffs
The West Coast of the U.S. has a vast offshore wind energy (OWE) electricity generation potential with value on the order of billions of USD, and pressure is mounting to develop large OWE projects. Ho...
Correction: National income accounting attributes and economic welfare. Evidence from Pakistan
Eosinopenia as a predictor of clinical outcomes in hospitalized patients with community-acquired pneumonia: A retrospective cohort study
Eosinopenia has been reported as a predictor of unfavorable outcomes and a marker of severity in bacterial infections. We describe the association between eosinopenia and clinical outcomes in hospital...
An optimized machine learning framework for predicting and interpreting corporate ESG greenwashing behavior
The accurate prediction and interpretation of corporate Environmental, Social, and Governance (ESG) greenwashing behavior is crucial for enhancing information transparency and improving regulatory eff...
Centrality nearest-neighbor projected-distance regression (C-NPDR) feature selection for correlation-based predictors with application to resting-state fMRI study of major depressive disorder
Background Nearest-neighbor projected-distance regression (NPDR) is a metric-based machine learning feature selection algorithm that uses distances between samples and projected differences between v...
Correction: Efficacy of probiotic supplements in the treatment of sarcopenia: A systematic review and meta-analysis
Limnological data derived from high frequency monitoring buoys are asynchronous in a large lake
Autonomous data collection is rapidly becoming an integral part of water quality monitoring, particularly for agencies looking to manage and protect aquatic ecosystems. While beneficial, it is unclear...
Promoting language and literacy through shared book reading in the NICU: A scoping review
Background Infants in the neonatal intensive care unit (NICU) are at a heightened risk for language and literacy delays and disorders. Despite the well-established empirical support for early shared...
Examining the relationship between income and both mental and physical health among adults in the UK: Analysis of 12 waves (2009–2022) of Understanding Society
There is growing evidence of a causal relationship between income and health. At the same time, pressure on reactive health and care services in the UK is increasing. Previous work to quantify the rel...
Exploring bioactive compound origins: Profiling gene cluster signatures related to biosynthesis in microbiomes of Sof Umer Cave, Ethiopia
Sof Umer Cave is an unexplored extreme environment that hosts novel microbes and potential genetic resources. Microbiomes from caves have been genetically adapted to produce various bioactive metaboli...