PLoS ONE
Articles in this Issue
The burden of unlawful use of opioid and associated epidemiological characteristics in Africa: A scoping review
Introduction There is an ongoing global upsurge of opioid misuse, fatal overdose and other related disorders, significantly affecting the African continent, due to resource-limited settings and poor...
Sequences within and upstream of the mouse Ets1 gene drive high level expression in B cells, but are not sufficient for consistent expression in T cells
The levels of transcription factor Ets1 are high in resting B and T cells, but are downregulated by signaling through antigen receptors and Toll-like receptors (TLRs). Loss of Ets1 in mice leads to ex...
Patient-Selection of a Clinical Trial Primary Outcome: The ENHANCE-AF Outcomes Survey
Introduction Before the initiation of the ENHANCE-AF clinical trial, which tested a novel digital shared decision-making tool to guide the use of anticoagulants in stroke prevention for patients with...
Trypanosomes lack a canonical EJC but possess an UPF1 dependent NMD-like pathway
The exon junction complex (EJC) is a key player in metazoan mRNA quality control and is placed upstream of the exon-exon junction after splicing. Its inner core is composed of Magoh, Y14, eIF4AIII and...
Trichoderma sp. AH pretreatment improves organic oxygen composites from supercritical alcoholysis of wheat straw
Electrospray ionization fourier transform ion cyclotron resonance mass spectrometry was applied to evaluate the organic oxygen composites (OOCs) in methanol fraction derived from the supercritical alc...
Advances in analytical approaches for background parenchymal enhancement in predicting breast tumor response to neoadjuvant chemotherapy: A systematic review
Background Breast cancer (BC) continues to pose a substantial global health concern, necessitating continuous advancements in therapeutic approaches. Neoadjuvant chemotherapy (NAC) has gained promine...
Phenological strategies of an evergreen tree in the Caatinga
Seasonally Dry Tropical Forests (SDTF) account for 40% of global tropical forests, with the Caatinga standing out as the largest continuous formation of this type. However, the region faces severe thr...
Hypertension associated with serotonin reuptake inhibitors: A new analysis in the WHO pharmacovigilance database and examination of dose-dependency
Introduction Recent literature has reported instances of drug associated with hypertension with serotonin reuptake inhibitors (SRIs). Nonetheless, the association between SRIs and hypertension develop...
A new method for detection of microbursts via point observation methods and field measurement for validation study with Doppler weather radar
Wind shear (WS) phenomena are critical in many applications, especially in aviation, wind energy and urban planning. Microburst (MB) detection is important for ensuring safety during aircraft landing/...
Negative impact of chemotherapy on kinetic growth rate of the future liver remnant if applied following PVE or ALPPS
Purpose Modern liver surgery has improved the percentage of potentially resectable malignant tumors. However, if the future liver remnant is small, patients remain at risk of developing postoperative...
Expression of Concern: Assessing clinical and morphological features of megalotrichosis induced by Tyrosine kinase inhibitors versus Prostaglandins analogues
Unveiling the silent threat: Investigating asymptomatic plasmodium infections in Gorgora, Ethiopia through microscopy and loop-mediated isothermal amplification
Background The asymptomatic carriers of the Plasmodium parasite represent a large hidden reservoir of Plasmodium species. These individuals can carry microscopically detectable levels and sub-microsc...
Predictors of clozapine concentration and psychiatric symptoms in patients with schizophrenia
Clozapine has superior efficacy to other antipsychotics, especially in patients with treatment-resistant schizophrenia. However, its pharmacokinetics and pharmacodynamics vary largely among patients....
Energy evolution and damage ontology modeling of coal destruction at different water contents
The aim of this study was to investigate the energy evolution characteristics and an ontological model of the deformation of coal under different water contents. Uniaxial compression tests were conduc...
Healthcare utilization trends in adults with asthma or COPD during the first year of COVID-19 pandemic in comparison to pre-pandemic: A population-based study
Objectives To assess how changes in outpatient services during the first year of the COVID-19 pandemic were related to acute healthcare use (emergency department or hospitalizations) for individuals...
Medical students’ and educators’ opinions of teleconsultation in practice and undergraduate education: A UK-based mixed-methods study
Introduction As information and communication technology continues to shape the healthcare landscape, future medical practitioners need to be equipped with skills and competencies that ensure safe, h...
Unveiling the digital revolution: Catalyzing total factor productivity in agriculture
Drawing upon panel data spanning the years 2011 to 2022 and encompassing 30 provinces across China, this research employs empirical methodologies, specifically the difference GMM and system GMM method...
Increased galanin-galanin receptor 1 signaling, inflammation, and insulin resistance are associated with affective symptoms and chronic fatigue syndrome due to long COVID
Background Patients with Long COVID (LC) often experience neuropsychiatric symptoms such as depression, anxiety, and chronic fatigue syndrome (CFS), collectively referred to as the...
Location estimation of UWB-based wireless capsule endoscopy using TDoA in various gastrointestinal simulation models
Wireless capsule endoscopy (WCE) is a revolutionary field that aids in treating gastrointestinal disorders. For the development of a futuristic endoscopic capsule, identifying the location of abnormal...
Antifreeze proteins produced by Antarctic yeast from the genus Glaciozyma as cryoprotectants in food storage
Synthesis of antifreeze proteins (AFPs) is one of the adaptations of psychrophilic yeast to live in cold environments. AFPs demonstrate thermal hysteresis (TH) activity and inhibit the recrystallizati...
The impact of urban parks on the thermal environment of built-up areas and an optimization method
Rapid urbanization, while transforming people’s living environments, also brings a series of urban issues such as the urban heat island effect. The urban park is an effective means to alleviate the ur...
Multilevel analysis of undergoing clinical breast examination and its associated factors among mothers of reproductive age in Kenya: Kenyan Demographic and Health Survey 2022
Introduction Breast cancer is one of the most common public health concerns among women around the world. The incidence of breast cancer is increasing in all areas of the world. It is the first cause...
Preliminary investigation of anti-fatigue effects and potential mechanisms of meiju oral liquid in mouse and zebrafish models
Meiju Oral Liquid (MOL), a representative medicinal formula in China, stems from the traditional use of specific Chinese medicinal herbs known for their anti-fatigue properties, including rose, jujube...
An exploration of the support received by mothers for kangaroo mother care practice along the health facility-community continuum in a sub-district of Northern Karnataka, India
Introduction Early initiation with optimal duration of Kangaroo Mother Care (KMC), for all stable small babies (<2000grams at birth), is essential for accelerated reduction of neonatal mortality. T...
Happy-Productive worker thesis: The role of work characteristics, gender, and age
Happy-productive worker thesis (HPWT) research predicts four configurations depending on well-being and performance levels, one synergistic and three antagonists; however, there has been some discrepa...