PLoS ONE
Articles in this Issue
Comprehensive multi-omics analysis reveals the prognostic and immune regulatory characteristics of the PTPN family in osteosarcoma
Osteosarcoma is a highly aggressive bone tumor that primarily affects adolescents and young adults, posing significant challenges in therapeutic efficacy, prognostic assessment, and treatment strategi...
Effects of urbanization and land expropriation on the livelihoods of peri-urban farmers in North Wollo Zone, Ethiopia
The aim of this study was to examine the effects of urbanization and land expropriation on the livelihoods of Peri-urban farmers in North Wollo Zone, Ethiopia. Data were collected from 378 peri-urban...
Effect of the exposure to brominated flame retardants on hyperuricemia using interpretable machine learning algorithms based on the SHAP methodology
Background Brominated flame retardants (BFRs) are classified as important endocrine disruptors and persistent organic pollutants; nevertheless, there is no comprehensive investigation to evaluate the...
Rare and novel variant load threshold for KIF7, GJA1 and PDE1C genes elevates the risk of severity of congenital heart defects in Down syndrome
Individuals with Down syndrome (DS) exhibit a higher incidence of congenital heart defects (CHD). The objective of the present study was to investigate ethnicity-specific genetic variants that increas...
Alpha-1 Antitrypsin Deficiency-Associated panniculitis: A survey of lived experience
Introduction Alpha-1 Antitrypsin Deficiency (AATD)-associated panniculitis is a rare inflammatory condition characterized by painful subcutaneous plaques or nodules, often accompanied by ulceration or...
Approaches and results of intersectoral actions for tuberculosis control in the world: A scoping review
Background Tuberculosis is a neglected disease with a wide global scope that overcomes public health challenges, also constituting an obstacle to social development. In the effort to control the disea...
Impact of out-of-pocket expenses on children with cancer in Tanzania: A mixed-methods economic study
Background For children with cancer in low- and middle-income countries, medical and non-medical expenses are often paid through out-of-pocket (OOP) expenditures, which pose significant barriers to ti...
Fatty liver index and risk of type 2 diabetes of adults with normoglycemia: Insights into insulin sensitivity and beta-cell function
The fatty liver index (FLI) is a simple tool used to assess metabolic dysfunction-associated fatty liver disease (MAFLD). Previous studies have shown the utility of the FLI as an early predictor of di...
Influence of capping agents on physicochemical properties and leukemic cytotoxicity of copper oxide nanoparticles biosynthesized using Caesalpinia sappan extract
The aim of this study was to investigate the effects of capping agents on the physicochemical and biological properties, particularly their leukemic cytotoxicity, of copper oxide nanoparticles (CuONPs...
Screening for developmental delay at 18 months using the Infant Toddler Checklist: A validation study
Objective The Infant Toddler Checklist (ITC) may be promising as a single tool at the 18-month visit to detect a range of developmental concerns. We examined the predictive validity of the ITC; and th...
The association between agricultural activities and arthritis in middle-aged and elderly people: Findings from a cohort study based on CHARLS
The number of arthritis samples in China has been increasing. Currently, there is limited research on the relationship between agricultural activities and arthritis. This study aimed to investigate th...
Health behavior and mental health by gender in Korean adults before, during, and after the COVID-19 pandemic
Objective Coronavirus disease 2019 (COVID-19) has been a global health crisis, and its aftermath has had a profound impact on mental health and health behaviors of Korean adults. This study aimed to d...
The interplay between foraging choices and population growth dynamics
Population growth models typically incorporate attributes observable at the population scale, often overlooking the trade-off between individual-level reproductive and behavioral traits and their infl...
Superior cardiovascular protection with GLP-1 RAs over SGLT2 inhibitors in DM and HFpEF: A propensity score matching study
Background Heart failure with preserved ejection fraction (HFpEF) and diabetes mellitus (DM) are interrelated conditions associated with high morbidity and mortality. This study compared the cardiovas...
Individualized diagnosis of rheumatoid arthritis: A rank-based qualitative T cell-related signature
Rheumatoid arthritis (RA) is a systemic autoimmune disease with persistent synovitis and joint destruction, leading to a huge economic and physical burden on patients. The detection of RA is important...
Enhancing reproducibility in stable isotope analysis (SIA) of fish eye lenses: A comparison between lamina number and diameter
Analyzing stable isotopes in archival tissues, such as fish eye lenses, is used to document shifts in feeding ecology, diet, habitat use, and to reconstruct life history. Fish eye lenses grow througho...
Genetically modified organisms and sustainable development goals: A survey of Taiwanese public opinion
This study investigates public opinion of genetically modified organisms (GMOs), the role of GMOs in achieving the Sustainable Development Goals (SDGs), and economic preferences in Taiwan. A survey of...
Adaptive DDoS detection mode in software-defined SIP-VoIP using transfer learning with boosted meta-learner
The Internet has continued to provision its infrastructure as a platform for competitive marketing, enhanced productivity, and monetization efficacy. However, it has become a means for adversaries to...
Measurement properties of health-related quality of life instruments for people living with scoliosis in China: A systematic review
Purpose Scoliosis is a three-dimensional structural deformity of the spine that leads to restricted spinal motion, weakness in the paraspinal muscles, reduced cardiopulmonary function, and chronic phy...
A novel dual-branch network for comprehensive spatiotemporal information integration for EEG-based epileptic seizure detection
Epilepsy is a neurological disorder characterized by recurrent seizures caused by abnormal brain activity, which can severely affects people’s normal lives. To improve the lives of these patients, it...
Whole genome sequencing revealed esophageal squamous cell carcinoma related biomarkers
Esophageal squamous cell carcinoma (ESCC) is among the most frequently diagnosed cancer types, and affected patients frequently experience poor prognostic outcomes and high mortality rates. Many genom...
Pneumococcal colonization dynamics among young children with and without respiratory symptoms during the first year of the SARS-CoV-2 pandemic
Background Non-pharmaceutical interventions to mitigate the spread of SARS-CoV-2 were implemented across the United States in 2020. These public health measures might influence pneumococcal colonizati...
Breaking the deadlock: A study on the pathway and effects of reshaping the sustainable marketing capability of Chinese time-honored brands
Numerous Chinese Time-Honored Brands are facing decline due to their limited ability to adapt to rapidly changing environments. This study identifies the core barrier as a lack of focus on developing...
Feasibility of a combined online and in-person training model on Infant and Young Child Feeding (IYCF) counselling for village health workers in rural Qinghai, China
Background Counselling is an effective behavior change intervention for improving infant and young child feeding (IYCF). The Maternal and Health Department of National Health Commission China and Unit...
Lactoferrin combined with Coenzyme Q10 ameliorate sarcopenia in an aging mouse model induced by D-galactose
Sarcopenia is an age-related condition with a slow and prolonged decrease in muscular mass, strength, and function. As the population ages, the frequency of sarcopenia rises, and aggressive prevention...