PLoS ONE
Articles in this Issue
Synergistic effects of notoginsenoside R1 and saikosaponin B2 in atherosclerosis: A novel approach targeting PI3K/AKT/mTOR pathway and macrophage autophagy
Atherosclerosis (AS) is a major global contributor to cardiovascular diseases and associated mortality. The traditional treatment primarily relies on statins; however, these drugs are often linked to...
Associations of green space visitation patterns with sociodemographics, health, and perceptions: A cluster analysis using smartphone Wi-Fi and GPS data
Understanding the multiple impacts of green spaces on individual health and overall quality of life is a key factor in urban planning and public health promotion. This study integrated smartphone Wi-F...
Signal preprocessing for foreign body detection using terahertz real-time non-destructive imaging system
Lipoprotein(a) levels in a sample of 115,197 subjects from the largest Brazilian private laboratory
Lipoprotein(a) (Lp(a)) is an independent risk factor for atherosclerotic disease and is increasingly being incorporated into clinical algorithms of cardiovascular risk prediction. However, the epidemi...
Prediction of therapeutic dropout in patients with addictions: Development and validation of the Predictors of Dropout from Addiction Treatment (PDAT) scale
Background Withdrawal from addiction treatment is a frequent but difficult-to-predict contingency. We clarify and contextualize the concept of dropouts in addiction treatment, as well as the external...
Correction: Relationship between physical function and sarcopenia in the older adults from Amazonas: A cross-sectional study
A nonlinear polycrystalline ice elastoplastic contact model and its application
With the gradual warming of the global climate, the possibility and risk of large-scale sliding and collapse disasters of glaciers, large ice sheets, and thicker ice sheets have increased. Using the d...
Circular insights for rhythmic health: A Bayesian approach with stochastic diffusion for characterizing human physiological rhythms with applications to arrhythmia detection
Accurate detection of arrhythmic patterns in physiological signals—particularly electrocardiogram (ECG)—is vital for early diagnosis and intervention. Traditional amplitude-based models often fail to...
The relationship between the Geriatric Nutritional Risk Index and all-cause mortality in patients with peripheral artery disease
Background Peripheral artery disease (PAD) is a common atherosclerotic condition that leads to limb dysfunction and increases mortality risk. Malnutrition is closely related to the long-term mortality...
The effect of camel milk on house dust mite allergen induced asthma model in BALB/C mice
Camel milk has demonstrated robust immunomodulatory and anti-inflammatory properties in various clinical and experimental studies. However, no previous studies have characterized the cellular immunolo...
Association between N-terminal pro-brain natriuretic peptide levels and outcomes of ischemic stroke: A systematic review and meta-analysis
Background N-terminal pro-brain natriuretic peptide (NT-proBNP) was identified as an important biomarker of cardiovascular disease, in ischemic stroke. This study intends to assess the association of...
Development of a highly specific enzyme-linked immunosorbent assay for detection of antibodies to Duck Tembusu virus using subviral particles
Duck Tembusu virus (DTMUV) belongs to the family Flaviviridae and genus Orthoflavivirus. It causes disease in ducks, affecting the nervous system and significantly reducing egg production. The first o...
Diazotrophic growth of free-living Rhizobium etli: Community-like metabolic modeling of growing and non-growing nitrogen-fixing cells
Rhizobium etli, a nitrogen-fixing bacterium, grows both in symbiosis (with plants) and in free-living state. While most metabolic models focus on its symbiotic form, this study refined the existing iO...
Diurnal pattern of respiration in corals and algae and its implications for gross primary production quantification
Mitochondrial respiration (R) and gross photosynthesis (GP) are crucial components of the energy and carbon budgets of photosynthesizing organisms in coral reefs. This study investigates the diurnal a...
Taxes to red and processed meat to promote sustainable and healthy diets in Mexico
Background Consumption of red and processed meat is above sustainable and healthy dietary targets in Mexico. Policies to promote greater adherence such as taxing meat are needed to reduce consumption....
Inhibitory effects of a hot-water extract of cumin fruit on influenza A virus infection
The influenza A virus (IAV) is an extremely contagious virus responsible for both seasonal flu and global pandemics. Cumin (Cuminum cyminum L., family Apiaceae) is a spice widely used in numerous Asia...
Optimising access to vocational rehabilitation through multiple sclerosis charities: Protocol for a feasibility randomised controlled trial
Background People with multiple sclerosis (MS) often leave the workforce prematurely due to MS symptoms and difficulties managing workplace relationships and performance. Vocationa...
A mixture of ginger phenolic compounds enhances mitochondrial function, activates AMPK, and reduces lipid accumulation in adipocytes
Mitochondrial abundance and activity in adipocytes are critical for adequate adipose tissue function and whole-body energy homeostasis. Mitochondrial dysfunction in adipocytes impairs lipid metabolism...
Response study of tower crane and elastic plate under dynamic complicated excitation
Structural vibration will inevitably occur under the dynamic complicated excitations in tower crane and elastic plate system. The continuous nonlinear vibration would lead to the deterioration of the...
Retraction: Effect of co-encapsulation using white and red onion peel extract on the viability and stability of Lacticaseibacillus rhamnosus under stressful conditions
Isotopes, herds, and landscape management practices: New insights on early farming communities in the Serpis Valley (Eastern Iberian Peninsula)
The establishment of the first livestock communities in the eastern Iberian Peninsula during the 6th millennium cal BCE marked a significant transition in the region’s economic system. The research of...
Application of video surveillance in preclinical safety studies in canines: Understanding the interobserver reliability and validity to recognize clinical behavior
Preclinical in vivo studies are critical to identify potential adverse effects of drugs under development. However, a significant number of drug candidates are terminated during human clinical trials...
Research on atmospheric temperature change and its adaptive strategies in winter wheat and summer maize dual-cropping region of North China Plain during 1961–2021—A case study of Jiaozuo City in Henan Province
Global warming has caused the frequency and intensity of extreme weather events in agriculture. Therefore, research on temperature changes in major grain-producing areas is essential for formulating a...
Hepatitis B virus X protein (HBx)-mediated immune modulation and prognostic model development in hepatocellular carcinoma
Hepatitis B virus (HBV) X protein (HBx) is critical in hepatocellular carcinoma (HCC) development, but its influence on tumor immunity and the tumor microenvironment (TME) remains unclear. This study...
Multimodal MRI radiomics based on habitat subregions of the tumor microenvironment for predicting risk stratification in glioblastoma
Objective Accurate prediction of glioblastoma (GBM) progression is essential for improving therapeutic interventions and outcomes. This study aimed to develop and validate an integrated clinical-radio...