PLoS ONE
Articles in this Issue
The Wnt pathway induces a naïve-like subpopulation in primed stem cells, while NME7AB leads to a homogeneous naïve-like population
The literature is replete with conflicting reports as to whether the Wnt/β-catenin pathway induces human stem cell differentiation or pluripotency. Recently, scientists showed that human stem cells ex...
Mediating role of growth mindset between college life stress and adjustment to college life among nursing students: A-cross sectional study
Adjusting to college life is important for nursing students to achieve academic and work performance successfully. Growth mindset has been proposed as a mediating concept that can induce positive psyc...
A rubric for assessing conformance to the Ten Rules for credible practice of modeling and simulation in healthcare
The power of computational modeling and simulation (M&S) is realized when the results are credible, and the workflow generates evidence that supports credibility for the context of use. The Commit...
HMGB1-BoxA gene therapy in reversing cisplatin resistance in non-small cell lung cancer
Cisplatin is a widely used chemotherapy agent in the treatment of non-small cell lung cancer (NSCLC). However, its clinical efficacy is limited by the development of drug resistance in patients with N...
Understanding the audiological care of patients with co-existing dementia or mild cognitive impairment and hearing loss in the United Kingdom National Health Service: A qualitative study
Background Hearing loss is common among people living with dementia and can exacerbate the symptoms associated with dementia. The effective management of hearing loss can positively impact quality of...
A framework for detecting and predicting highway traffic anomalies via multimodal fusion and heterogeneous graph neural networks
This paper presents a novel framework for detecting and predicting abnormal traffic events on highways. Current traffic monitoring systems often rely on single data sources, which limits their detecti...
Effect of telemedicine-supported structured exercise program in patients with chronic low back pain: a randomized controlled trial
Background Structured exercise programs delivered via telemedicine have the potential to benefit patients with chronic low back pain (CLBP). However, evidence-practice gaps exist, such as low exercise...
Correction: In vivo biocompatibility and long-term durability of nanofibrillated cellulose as a urethral bulking agent in rats and Beagle dogs
Subtypes of hypertension and their association to comorbidities and ethnicity in pregnant women
Objectives We analyzed the subtypes of arterial hypertension and their relationship with different comorbidities and ethnicity during pregnancy. Study design This is a retrospective observational co...
Life-time experience of violence among women and girls living with disability in Nepal
Background Violence against women and girls with disabilities remains a serious, yet underexplored, global concern. This paper aims to investigate the prevalence and factors associated with life-time...
Exploring a role for Chemerin in the cardiovascular and musculoskeletal benefits of intradialytic exercise in the hemodialysis population
Background Cardiovascular disease is the leading cause of death for people receiving hemodialysis. Intradialytic cycling (IDC) has been shown to improve cardiovascular health in the hemodialysis popul...
SNAI2 cooperates with MEK1/2 and HDACs to suppress BIM- and BMF-dependent apoptosis in TERT promoter mutant cancers
Cancers with TERT promoter mutations (TPM) display elevated RAS pathway signaling and mesenchymal traits, and associate with lower patient survival rates. We examined whether RAS pathway signaling in...
Evaluation of potential of targeted sequencing through mutational signature simulation
Background Targeted sequencing is critical in cancer diagnosis, treatment selection, and monitoring. However, the effectiveness of these methods for reflecting whole-exome sequencing (WES)-level mutat...
Leveraging multi-modal data for early prediction of severity in forced transmission outages with hierarchical spatiotemporal multiplex networks
Extended power transmission outages caused by weather events can significantly impact the economy, infrastructure, and residents’ quality of life in affected regions. One of the challenges is providin...
Association between CYP17A1 rs743572 polymorphism and cancer risk: A meta-analysis
The role of the CYP17A1 gene’s rs743572 polymorphism in cancer susceptibility has been a subject of extensive investigation, yet existing evidence remains inconclusive. In this meta-analysis, we syste...
Demographic rise of sea urchin Centrostephanus sylviae on Robinson Crusoe and Santa Clara Islands at the Juan Fernandez Archipelago: A biophysical and ecological approach
The large increase in the population of long-spined sea urchins (Centrostephanus sylviae) has gained significant attention in the past decade due to the rise in the number of individuals reported as b...
Construction of VAE-GRU-XGBoost intrusion detection model for network security
With the advent of the big data era, the threat of network security is becoming increasingly severe. In order to cope with complex network attacks and ensure network security, a network intrusion dete...
Exploring the potential of blood and urine protein electrophoresis in predicting 1-year mortality in acute kidney injury
This retrospective cohort study aimed to assess the predictive value of protein fractions obtained from blood and urine protein electrophoresis, along with various clinical and laboratory parameters,...
Telomere length as a biomarker for cumulative experience in broiler chickens
Cumulative experience can be defined as the sum of all positive and negative experiences during an animal’s lifetime. Telomere length shows promise as a biomarker of cumulative experience in humans an...
Assessment of patient safety culture among healthcare employees in major Eswatini public hospitals
This primary study assessed the patient safety culture in five major public government hospitals in Eswatini. A cross-sectional survey was conducted among hospital employees using the validated Hospit...
Statin adherence improves with age and subsequent treatment sequences: A retrospective cohort study using Proportion of Days Covered (PDC)
Background Dyslipidaemia is a key risk factor for atherosclerotic cardiovascular disease (ASCVD), necessitating effective statin therapy. Despite statins’ proven safety and efficacy, adherence remains...
Harnessing enzyme promiscuity of alditol-2-dehydrogenases for oxidation of alditols to enantiopure ketoses
Several alditol-2-dehydrogenase enzymes from the short chain dehydrogenase (SDR) family catalyze the production of enantiopure rare ketoses from alditols as substrates and are used in biotech industry...
Correction: Association of electronic learning devices and online learning properties with work-related musculoskeletal disorders (WMSDs): A cross-sectional study among Thai undergraduate students
High school science fair: What students say—mastery, performance, and self-determination theory
Most high school students indicate that participation in science and engineering fairs (SEFs) increased their interest in science and engineering (S&E). The underlying appeal of SEF participation...
Inadequate lumbar protection with load weight limits based on body weight percentages: An experimental and simulation study of the weight limits set by the Japanese guidelines for preventing low back pain
Work-related low back pain is the most prevalent occupational disease in Japan, with 25% of cases resulting from manual handling of heavy loads. The Ministry of Health, Labor and Welfare of Japan has...