PLoS ONE
Articles in this Issue
Desmin disorganisation: A key feature in feline hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy is usually characterised histologically by increased ventricular wall thickness and myocyte disarray. In human and rodent HCM, subcellular alterations were detected that in...
Exploring sentiments and topics in Extended Reality learning environments: A comparative study
This study explored online users’ sentiments about the use and application of Extended Reality (XR) in higher education. X social media platform was used as the main source for assessing users’ percep...
Analyzing crises in global financial indices using Recurrent Neural Network based Autoencoder
In this study, we present a novel approach to analyzing financial crises of the global stock market by leveraging a modified Autoencoder model based on Recurrent Neural Network (RNN-AE). We analyze ti...
Retraction: Management practice, and adherence and its contributing factors among patients with chronic kidney disease at Tikur Anbessa Specialized Hospital: A hospital-based cross-sectional study
Structural and functional impact of the p.R163C mutation in the conserved palindromic motif within the C-terminal domain of human αB-crystallin
Human αB-crystallin is a small heat shock protein that functions as a chaperone and anti-apoptotic protein to maintain cellular protein integrity. A specific mutation (p.R163C) in the C-terminal domai...
Depressive disorders, bad mental health days, and diabetes management behaviors among non-Hispanic American Indian/Alaska Native adults: Findings from the Behavioral Risk Factor Surveillance System
Objective This study examined the association between diagnosis of depressive disorder, the number of bad mental health days per month, and diabetes management behaviors among American Indian/Alaska N...
Obesity induced transcriptional changes in skeletal muscle across different species
Pigs on high-fat diets maintaining metabolic homeostasis and are resistant to hepatic steatosis, differing from humans and mice. Obesity-induced metabolic dysregulation and inflammation in skeletal mu...
Impacts of land use on soil carbon, nitrogen, and phosphorus in the Eastern Qilian Mountains
The dynamics and balance of soil carbon, nitrogen, and phosphorus significantly affect soil microbial activity and plants’ nutrient absorption and utilization. Understanding how different land-use typ...
Retraction: RTA408 alleviates retinal ganglion cells damage in mouse glaucoma by inhibiting excessive autophagy
Exploring the challenges and needs of nursing students in relation to OSCE exam stress: A qualitative study
Background The Objective Structured Clinical Examination (OSCE) is a critical assessment method in nursing education but is often associated with significant stress, negatively impacting students’ psy...
A non-enzymatic doxycycline absorbance sensor based on manganese-doped zinc sulfide nanoparticles coated with chitosan
The need for doxycycline detection is urgent because it is a vital antibiotic extensively utilized to combat bacterial diseases in humans and animals, and it is now at the forefront of the global batt...
Retraction: Berberine inhibits invasion and metastasis of colorectal cancer cells via COX-2/PGE2 mediated JAK2/STAT3 signaling pathway
Priority setting for nutrition research in individuals with spinal cord injury: A protocol for Delphi study among health professionals
Study design A protocol for Delphi Consensus Study. Objectives To identify a top ten list of priorities for future nutrition research in individuals with spinal cord injury (SCI). Setting The Inte...
Tenofovir alafenamide is superior to tenofovir disoproxil fumarate and entecavir in cost-effectiveness of treatment of chronic hepatitis B in china with new volume-based procurement policy
Background Evidence supports the long-term efficacy of Nucleos(t)ide Analogs (NAs) therapy in improving chronic hepatitis B (CHB) prognosis. However, determining the most cost-effective first-line NAs...
Losartan as a mechanotherapeutic adjuvant: Remodeling the breast tumor microenvironment to improve treatment efficacy
Tumor stiffness is a critical factor influencing cancer progression, therapeutic resistance, and drug delivery. This study investigates the role of mechanical normalization in breast cancer therapy th...
Modelling key ecological factors influencing the distribution and content of silymarin antioxidant in Silybum marianum L.
The increasing demand for natural medicine has increased the significance of Silybum marianum as a valuable medicinal plant. It is used to restore liver cells; reduce blood cholesterol; prevent prosta...
Time trends incidence of celiac disease in a Spanish population
Background/Objective Very few studies on celiac disease (CD) incidence across all age groups have been carried out so far, particularly in Spain. We evaluate the time trend incidence of CD of children...
Evaluating the kidney disease progression using a comprehensive patient profiling algorithm: A hybrid clustering approach
Background Acute kidney injury (AKI) can lead to an approximate ninefold increased risk for developing chronic kidney disease (CKD). Despite this, many AKI survivors lack proper ne...
Compressed sensing-based image reconstruction for discrete tomography with sparse view and limited angle geometries
This paper addresses the image reconstruction problem in discrete tomography, particularly under challenging imaging conditions such as sparse-view and limited-angle geometries commonly encountered in...
Pre-clinical evaluation of a low-cost tool for skin temperature measurements as a proxy to assess autonomic nerve function in leprosy neuropathy
Peripheral autonomic nerve function (ANF) impairment (ANFI) can be one of the first indicators for leprosy or leprosy neuropathy. However, within leprosy, hardly any ANF assessment methods are used in...
Cysteine pattern barcoding-based dataset filtration enhances the machine learning-assisted interpretation of Conus venom peptide therapeutics
Crude cone snail venom is a rich source of bioactive compounds with significant therapeutic potential. In this study, we conducted a comprehensive analysis of 5,985 cone snail peptides across 82 Conus...
Herd immunity and prevention in HPV transmission with exogenous reinfection
Cervical cancer is a major global health concern, primarily caused by human papillomavirus (HPV), which spreads through unsafe sexual contact. Natural immunity often fails to provide full protection,...
Low-methoxy pectin-containing enteral nutrition in critical care for intestinal tolerance (LOME-PECT): Study protocol for a randomized controlled trial
Background Enteral nutrition is preferable over parenteral nutrition for critically ill patients, but is often discontinued due to enteral feeding intolerance. Diarrhea is one of the most common cause...
Objective hyperemia and intraocular pressure changes following omidenepag isopropyl application
Conjunctival hyperemia was the most common adverse drug reaction to the ophthalmic solution omidenepag isopropyl in a post-marketing observational study. Here, we prospectively examined changes in hyp...
A new method for ranking q-rung ortho-pair fuzzy numbers and application
The effectiveness of the q-rung ortho-pair fuzzy multi-attribute decision-making method is primarily influenced by the q-rung ortho-pair fuzzy number ranking method. This paper conducts an in-depth an...