PLoS ONE
Articles in this Issue
Unveiling Aducanumab’s safety profile: A comprehensive pharmacovigilance analysis
Background Aducanumab, a monoclonal antibody targeting amyloid-beta plaques, has been introduced as a pivotal therapeutic agent for Alzheimer’s disease (AD). Although it offers promising benefits in t...
Relative age effect, morphological status and physical performance of U-15 Croatian football players
The relative age effect (RAE) refers to the unequal quartal-to-quartal birth distribution in competitive sports, leading to more athletes being born earlier in the selection period. This effect result...
Tobacco smoking and smokeless tobacco use among people living with HIV in Zambia: Findings from a 2023 National NCD/HIV Survey
Background People living with HIV (PLWH) who use tobacco face significant public health risks compared to non-users, including an average loss of 12.3 years of life expectancy. Tobacco use increases t...
Correlation between pre-extraction periodontal diagnosis and peri-implant microbiome for patients treated with implant-retained overdenture – A retrospective cohort pilot study
Limited clinical data exists on the peri-implant microbiome in edentulous patients with implant-retained overdentures (IRO). This study aimed to examine the peri-implant microbiome and its correlation...
Land cover as a driver of fish community changes in New York’s Oswego River Watershed
Freshwater fish communities in New York State, USA, have been impacted by a variety of threats over the last century, including changes in land cover. Land cover exerts a powerful influence on aquatic...
Financial frictions and stock return: A novel least minus more frictional factor for asset pricing models in emerging economies
The primary objective of this study is to empirically evaluate the role of various levels of financial friction in explaining stock returns through different asset pricing models. This study enhances...
Predictive factors for failure of high flow nasal cannula among children with lower respiratory tract infection: A single center retrospective observational study
Background and objective Lower respiratory tract infection (LRTI) is a leading cause of childhood hospitalization worldwide, with high-flow nasal cannula (HFNC) therapy commonly employed as a non-inva...
Contrastive learning enhanced pseudo-labeling for unsupervised domain adaptation in person re-identification
Person re-identification (ReID) technology has many applications in intelligent surveillance and public safety. However, the domain difference between the source and target domains makes the generaliz...
Editorial Note: Lantana camara plant extract catalyzed biosynthesis of graphene-metal nanocomposites with potential cytotoxic activities
Association analysis of PAEP, KRT10, and BMP7 genes SNPs with reproductive traits in Kele pigs
This study aimed to investigate the effects of single nucleotide polymorphisms (SNPs) in progestogen-associated endometrial protein (PAEP), keratin 10 (KRT10), and bone morphogenetic protein 7 (BMP7)...
Investigating the relationship between internal spinal alignment and back shape in patients with scoliosis using PCdare: A comparative, reliability and validation study
Optical 3D surface scanning has emerged as a valuable modality for assessing spinal deformity in patients with scoliosis, avoiding radiation exposure. However, correlations remain moderate between def...
Decoding basic emotional states through integration of an fNIRS-based brain–computer interface with supervised learning algorithms
Automated detection of emotional states through brain-computer interfaces (BCIs) offers significant potential for enhancing user experiences and personalizing services across domains such as mental he...
In vitro 3D drug sensitivity testing for patient-derived tumor-like cell clusters and whole-exome sequencing to personalize postoperative treatment: A study protocol for a multicenter randomized controlled trial
Background Colorectal cancer (CRC) ranks as the third most common cancer globally, with significant postoperative recurrence and metastasis rates. The heterogeneity of CRC presents challenges in the s...
Enhancing hospital safety: The impact of resilience on safety climate, safety performance, and occupational accidents
This study examined the impact of individual and organizational resilience on safety climate, safety performance, and the incidence of occupational accidents among hospital employees in Iran. The rese...
The regulatory role of ZmSTOMAGEN1/2 in maize stomatal development is elucidated via gene editing and metabolic profiling
Stomatal development is mediated by EPIDERMAL PATTERNING FACTORs (EPFs), a family of secreted peptides including STOMAGEN/EPFL9 in Arabidopsis. To clarify the functional role of STOMAGEN orthologues i...
Associations of domestic hard water metrics with the risk of gout incidence and recurrence
Background Accumulating evidence suggests that domestic hard water is linked to health outcomes, but whether there is a potential association with gout is unknown.To examine the association between do...
Finger drawing on smartphone screens enables early Parkinson’s disease detection through hybrid 1D-CNN and BiGRU deep learning architecture
Background Parkinson’s disease (PD), a progressive neurodegenerative disorder prevalent in aging populations, manifests clinically through characteristic motor impairments including bradykinesia, rigi...
Completeness of reporting in abstracts of randomized controlled trials in dental medicine published from 2015–2023: A methodological study
Background Well-reported scientific abstracts are essential as they provide a concise summary of key research findings. Our study aimed to assess the completeness of reporting in abstracts of randomiz...
Assessing the global burden of Type 2 diabetes in women of reproductive age
This research critically assesses the global prevalence and trends of Type 2 diabetes (T2D) among women of reproductive age (15–39 years) spanning the period from 1990 to 2021. We conducted an analysi...
The global burden of stroke attributable to high alcohol use from 1990 to 2021: An analysis for the global burden of disease study 2021
Background Stroke, a leading global cause of death and disability, has high alcohol consumption as a significant modifiable risk factor. Despite the known association, the global spatiotemporal burden...
Metabolomics analysis and mRNA/miRNA profiling reveal potential cardiac regulatory mechanisms in Yili racehorses under different training regimens
Yili horses, a versatile breed from Xinjiang, China, are renowned for their racing abilities. However, studies on the links between cardiac morphology, function, and metabolic profiles with performanc...
IQGAP1 participates in endothelial cell apoptosis and regulates atherosclerosis by targeting YAP
Endothelial cell (EC) apoptosis plays a crucial role in the onset and progression of atherosclerosis (AS). IQGAP1 is highly expressed in various tissues and affects cell growth, development and death....
A comprehensive accident investigation system for assisted driving vehicles: Addressing complexities in fault determination and responsibility allocation
China’s autonomous vehicle accidents, fault determination has grown increasingly complex due to the undefined legal status of autonomous driving systems. To assign responsibility accurately, it is cru...
Research on accuracy enhancement methods for highway slope deformation monitoring based on the BeiDou system
To address the issue of low accuracy caused by multipath effects in BeiDou satellite-based slope monitoring, this study proposes a multipath error mitigation technique based on the BeiDou Navigation S...
Process evaluation for the STAMINA randomised controlled trial: A protocol
Background STAMINA is a randomised controlled trial of a complex lifestyle intervention incorporating exercise prescription into a prostate cancer care pathway. The 12-month intervention aims to impro...