PLoS ONE
Articles in this Issue
Individual and facility level factors influencing timely antenatal care initiation in Ethiopia: A multilevel analysis of the 2021/2022 ESPA data
Background Antenatal care (ANC) is a package of healthcare services for pregnant women that improves the health of both the women and their unborn babies, with a minimum of eight times and most effect...
Interactive effects of developmental and adult nutrition on lifespan and fecundity in a genetically diverse Drosophila population
Developmental conditions, including temperature, diet, and parasite exposure, can shape adult fitness phenotypes across species. While studies often examine the independent effects of early-life and a...
Synergistic anticancer effects of ABT-199 and Vorinostat encapsulated in PLGA nanoparticles: Formulation, characterization, and antiproliferative effects against colorectal cancer cells
The combination of ABT-199, a BCL-2 inhibitor, and Vorinostat, a histone deacetylase inhibitor, holds great potential in colorectal cancer therapy due to their synergistic effects. However, their poor...
The relationship between auditory processing disorder and articulation disorders
Purpose Auditory processing disorder (APD) may attribute to certain speech problems, as auditory processing plays a vital role in phonetic development during childhood. This research investigates the...
Functional recovery 2-years after hospitalization for COVID-19: Insights from the COREG-FR extension study
Introduction COVID-19 infection can lead to multi-organ dysfunction, which has been shown to contribute to the physical disability seen in people after hospital discharge. We aimed to understand the e...
Advanced deep learning-based brain tumor classification using a novel customized CNN and optimized residual network
The uncontrollable and rapid growth of brain cells can lead to brain tumors. If left untreated, this condition may result in severe health consequences, including death. Accurate detection and classif...
Limited knowledge, low risk awareness, and eating out are associated with higher sugar-sweetened beverage consumption among adults aged 18–64 in Beijing
Objectives The purpose of this study was to analyze the prevalence of sugar-sweetened beverage (SSB) consumption among residents aged 18–64 in Beijing and to identify associated influencing factors....
Real-world study of adverse events associated with sodium zirconium cyclosilicate based on FDA adverse event reporting system and VigiAccess database
The aim of this study was to investigate frequencies, types, and signals of adverse drug events (ADEs) associated with sodium zirconium cyclosilicate (SZC) used for the treatment of hyperkalemia, in o...
Preparation of g-C3N4-based photocatalytic nanofibers and antibiotic degradation performance research
With the extensive use of antibiotics around the world, their contamination problem has now attracted increasing attention, and seeking effective antibiotic contamination management technologies has b...
Contextual barriers to PrEP uptake and continuation among young Black gay and bisexual men who have sex with men living in the South
Young, Black Gay, and Bisexual men who have sex with men (YBGBM) are disproportionately impacted by HIV, especially in Southern United States. We conducted a cross-sectional survey (Feb19-Mar20). Elig...
Effects of rumen-protected or unprotected Clostridium butyricum on growth performance, rumen fermentation, immunity and antioxidation in fattening goats
Probiotics have been suggested to promote growth and immune performance in animals through long-term feeding. Among probiotics, Clostridium butyricum (C. butyricum) has been shown to have varying effe...
On the effectiveness of network metrics on key class prediction: An empirical study
Key classes are the most important classes in a software system, which provide an excellent foundation for developers—especially those new to the field—to understand unfamiliar software systems. In th...
Generalized estimating equations for modeling cluster randomized trial data on smoking cessation among tuberculosis patients
There is a paucity of studies applying Generalized Estimating Equations (GEE) for longitudinal analysis of smoking cessation outcomes within the framework of a cluster randomized trial, especially amo...
DPP4 inhibitors as a novel therapeutic strategy in colorectal cancer: Integrating network biology and experimental insights
Colorectal cancer (CRC) ranks as the third most prevalent cancer worldwide and the second leading cause of cancer-related deaths. Despite advances in treatment, drug resistance remains a critical chal...
Comparative effects of lived experience-lecturer-guided and teacher-led classes on mental illness awareness among Japanese high school students
Improving mental health literacy in adolescents is a global priority. The purpose of this study is to examine differences in students’ attitudes across five components of mental health literacy—suppor...
Test-retest reliability and minimal detectable change of Dutch-Flemish Patient Reported Outcomes Measurement Information System (PROMIS®) Computerized Adaptive Tests for musculoskeletal disorders
Objective To examine the test-retest reliability and minimal detectable change (MDC) of the Dutch-Flemish Patient Reported Outcomes Measurement Information System (DF-PROMIS) Pain Interference (PI) v1...
Prevalence and epidemiology of presumptive cerebral microbleeds in a population of 747 dogs undergoing brain MRI: a retrospective study
Current advances in veterinary medicine have led to a significant increase in the longevity of dogs, and age-related brain changes have become more recognized, such as cerebral microbleeds (CMBs). How...
Editorial Note: Undergoing lignin-coated seeds to cold plasma to enhance the growth of wheat seedlings and obtain future outcome under stressed ecosystems
Early postoperative alignment and preoperative stereopsis as determinants of success in intermittent exotropia surgery
To assess the surgical outcomes of patients with intermittent exotropia (IXT) and identify factors influencing surgical success in a tertiary hospital setting. This retrospective study included 150 pa...
Tracing Neanderthal mobility through the Romanian Carpathians: A GIS-based least-cost connectivity model
Out of the 12,300 known caves within the Romanian Carpathian and Dobrudja mountain area, only 16 have been the focus of consistent archaeological researches which revealed traces of human activity (li...
A shape-based functional index for objective assessment of pediatric motor function
Clinical assessments for neuromuscular disorders, such as Spinal Muscular Atrophy (SMA) and Duchenne Muscular Dystrophy (DMD), continue to rely on subjective measures to monitor treatment response and...
Predictive value of urinary [TIMP-2]•[IGFBP7] for AKI among sepsis, stroke, and cardiac surgery cohorts: A prospective study
Background: TIMP-2 and IGFBP7 have shown effectiveness as biomarkers for predicting Acute Kidney Injury (AKI). However, the variations in the predictive capacity of urinary [TIMP-2]• [IGFBP7] for AKI...
Genetic diversity and population structure analysis of soybean [Glycine max (L.) Merrill] genotypes based on agro-morphological traits and SNP markers
Soybean (Glycine max) is one of the world’s most important oilseed crops and has adapted to various environmental conditions. Yields of soybeans in Nigeria are notably low due to different production...