PLoS ONE
Articles in this Issue
Retraction: Foot Loading Characteristics of Chinese Bound Feet Women: A Comparative Analysis
Hepatotoxicity risk factors in HIV-infected MSM with HBV/HCV coinfections: A cohort study in Northwestern China
Objective To evaluate the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) coinfections among human immunodeficiency virus (HIV)-infected men who have sex with men (MSM) initiating th...
Experience of uncertainty in prostate cancer: A qualitative study
Background Prostate cancer is characterised by significant uncertainty, yet men’s lived experience of uncertainty in this context remain underexplored. Existing research has primarily focused on uncer...
Structure-guided discovery and characterization of novel FLT3 inhibitors for acute myeloid leukemia treatment
FLT3 (FMS-like tyrosine kinase 3), a receptor tyrosine kinase, is frequently mutated in acute myeloid leukemia (AML), a hematologic malignancy marked by aggressive proliferation, poor prognosis, and h...
Data-driven assessment of Apulian road network resilience: Bridge unavailability and inner municipality isolation impact
Road networks are crucial for the movement of resources, passenger transportation, and supply chains. In seismically active areas like Italy, earthquakes can compromise road infrastructure, leading to...
Expression of Concern: Pneumonia remains a leading public health problem among under-five children in peri-urban areas of north-eastern Ethiopia
Synthesis, characterization and drug loading properties of a medical metal-organic framework constructed from bioactive curcumin derivatives
A novel medical metal-organic framework was successfully synthesized using curcumin derivatives, specifically 3, 5-bis (4-hydroxy-3-methoxystyryl) pyrazole, as ligands. These derivatives exhibit enhan...
A qualitative exploration of consumers’ views and experiences toward online pharmacies: Narrative from a developing country
Introduction The widespread adoption of the internet and online pharmacies has made accessing medications more convenient, especially with the growing use of smartphones in developing countries. While...
Uncovering key determinants of well-being among older Canadian retirees in New Brunswick: Protocol for a mixed-methods study
Aims To uncover the key determinants of physical, mental, social, financial, and spiritual well-being among older Canadian retirees living in New Brunswick and explore how individual, community, organ...
Fecal carriage and associated factors of extended-spectrum beta-lactamase-producing Enterobacteriaceae in children under five years old with diarrhea at a tertiary hospital in Tanzania
Background The prevalence of extended-spectrum beta-lactamase-producing Enterobacteriales (ESBL-PE) is high in resource-limited settings. Carriage in young children has been linked to increased morbid...
Dual-stage framework with soft-label distillation and spatial prompting for image-text retrieval
Vision-language pre-training (VLP) methods have significantly advanced cross-modal tasks in recent years. However, image-text retrieval still faces two critical challenges: inter-modal matching defici...
Incidence and predictors of chronic kidney disease among hypertensive patients in Ethiopia: A Bayesian multivariate joint model
Background Hypertension (HTN) is a major contributor to chronic kidney disease (CKD), a leading cause of global morbidity and mortality. In low-resource settings such as Ethiopia, where CKD risk facto...
Trends and projections of the global burden of T2DM-associated CKD related to high BMI: A global burden of disease study 2021
Background Type 2 diabetic-associated chronic kidney disease (T2DM-Associated CKD), a leading cause of end-stage renal disease, is exacerbated by rising particularly high body mass index (BMI) rates....
Development and internal validation of multimodal machine learning models for predicting eligibility for mechanical thrombectomy in suspected stroke patients using routinely collected clinical and imaging data
Background Mechanical thrombectomy (MT) eligibility for acute ischemic stroke (AIS) patients depends upon clinical and advanced imaging assessments like CT perfusion (CTP). Assessment complexities and...
Effect of bed height on laryngoscopy force and operator ergonomics during simulated endotracheal intubation: A randomized controlled study
Purpose Excessive force during laryngoscopy for endotracheal intubation can result in injury to airway soft tissues and hemodynamic stress responses. In this randomized controlled trial on simulated i...
Differential composition of the pulmonary microbiome in HIV-positive versus HIV-negative patients with Pneumocystis jirovecii
Pneumocystis jirovecii is frequently detected in HIV patients and individuals with compromised immune function. The clinical outcomes of these two groups differ significantly, yet the underlying reaso...
Hospital care does not meet the communication needs of patients with hearing loss: A qualitative study of patient experiences
Background Good communication is essential for high quality healthcare. People with hearing loss face communication challenges during health encounters, which may compromise their experience with care...
A longitudinal study of four-year changes in physical fitness among university students before and after COVID-19: 2019–2022
Background Physical fitness is a key indicator of health in youth and was significantly affected by the COVID-19 pandemic. However, longitudinal studies tracking pandemic-related fitness changes over...
Submaximal loading as a feasible alternative to supramaximal loading in accentuated eccentric loading during the short-term basic strength block
Purpose The purpose of this study was to compare the effects of supramaximal and submaximal accentuated eccentric loading (AEL) on lower-body function and hypertrophy during a short-term basic strengt...
Identification and evaluation of potential microRNA markers for diagnostics in neurodegenerative diseases and correlation with other biochemical markers
Objectives MicroRNAs (miRNA) are short, non-coding RNA molecules that play a crucial role in the development of organisms and are involved in various biological processes. They are considered potentia...
Antimicrobial and quorum sensing interference of a cysteine- and arginine-deleted linear Tachyplesin analog (CRDT) against Staphylococcus aureus and Pseudomonas aeruginosa
The rise of multidrug-resistant pathogens such as Staphylococcus aureus and Pseudomonas aeruginosa has driven the search for novel antimicrobial agents with enhanced efficacy and reduced toxicity. Tac...
High prevalence of poor sleep quality and sleep deficit: A study in children, adolescents, and adult soccer players
Objective This observational study aimed to provide insight into the sleep behaviors, chronotypes, and sleep needs of athletes by examining children, adolescents, and adult soccer players from differe...
Addressing oral health equity through community service-learning and person-centered care in Ontario: patient and provider perspectives
This study aimed to investigate the influence of the Community Service-Learning (CSL) program at Schulich Dentistry on the experiences and perceptions of patients and healthcare providers (HCP) at the...
Heparin improves the mortality of patients with non-pulmonary sepsis-associated ARDS: A MIMIC-IV database analysis based on propensity score matching
Background Non-pulmonary sepsis often induces Acute Respiratory Distress Syndrome (ARDS). Dysregulated inflammation and coagulation disorders play important roles in the development of non-pulmonary s...
Green synthesis of Fe2O3-MnO2 nano-hybrids on pumice for complete degradation of pharmaceutical pollutants
Pharmaceutical contaminants in wastewater pose critical environmental and public health risks due to their persistent nature and resistance to conventional treatment. To address this challenge, we dev...