PLoS ONE
Articles in this Issue
Social patterns underlying a new group formation in olive baboons
In group-living animals, social and ecological challenges can push groups to fission into two or more ‘daughter’ groups. Here, we describe the demographic and social behavioral changes that were assoc...
Discovery of C-12 dithiocarbamate andrographolide analogue as a novel antioxidant and α-glucosidase inhibitors: In vitro and in silico studies
Type 2 diabetes mellitus (T2DM) is a global health issue associated with oxidative stress, inflammation, and insulin resistance. Even though α-glucosidase inhibitors such as acarbose are used in treat...
A randomized trial of grant writing coaching groups: Baseline analysis of early-career scientists’ research background, demographics, and mentorship variables
Introduction Racial, ethnic, and gender disparities in academic career advancement persist in biomedical disciplines. One approach to addressing this problem is systematizing acces...
The experience and impact of living with idiopathic hypersomnia: A qualitative study of patient perspectives shared in online media
Introduction Understanding the experience and impact of idiopathic hypersomnia (IH) is critical for improving diagnosis, treatment, research, drug development, and policy awareness...
Association of the 2019 Canada’s food guide food choices assessment score with 10-year cardiovascular disease risk and heart age in Canadian adults
Healthy diet plays an important role in the prevention of cardiovascular disease (CVD), which is the second leading cause of death in Canada. In 2019, Health Canada released an updated Canada’s Food G...
QT prolongation and excessive variability predicts new-onset atrial fibrillation in the health screening data of Japanese adults
Background A prolonged QT interval (QTc) is associated with the development of atrial fibrillation. However, reports linking QTc variability and atrial fibrillation are limited....
Sleep duration and cognitive function among rural older adults in China: A population-based study
Background Appropriate sleep duration is essential for maintaining normal cognitive function, but evidence is scarce in rural elderly population. This study aims to determine the a...
Comparative evaluation of the antimicrobial, antioxidant, and cytotoxic properties of essential oils from vetiver, lemongrass, and clove buds with implications for topical application
For many years, essential oils (EOs) have gained attention as natural alternatives to synthetic antimicrobials and antioxidants, although their cytotoxicity remains a major concern for topical use. Le...
On the ecological impact of prehistoric hunter-gatherers in Europe: Early Holocene (Mesolithic) and Last Interglacial (Neanderthal) foragers compared
Recent studies have highlighted evidence of human impact on landscapes dating back to the Late Pleistocene–long before the advent of agriculture. Quantifying the extent of vegetation transformations b...
ABO blood groups and cardiovascular disease and its risk in continental Africans and people of African ancestry: A systematic review
Background Cardiovascular disease (CVD) remains a global health challenge and contributes substantially to mortality burden in sub-Saharan Africa (SSA) in particular. Several facto...
Help seeking for intimate partner violence in a resource-constrained setting: A latent class analysis of the Nigerian demographic health survey dataset
Help seeking for intimate partner violence (IPV) is a complex process that involves reaching out to an external party. Women in resource constrained settings face unique constraints when seeking help...
Effect of technological parameters on mechanical properties and microstructure of heat-assisted friction stir welded joints of 6061 aluminum alloy
This study investigates the influence of key technological parameters on the mechanical characteristics and microstructure of heat-assisted friction stir welded (FSW) joints of AA6061 aluminum alloy p...
Unpleasant but effective: Newspaper coverage of cancer screening and cancer in the Netherlands from 2010 to 2022
Participation rates in cancer screening programs (CSPs) have shown a declining trend, and research suggests that news media reports may contribute to public opinion. Therefore, we aimed to understand...
Correction: Chip-Based Comparison of the Osteogenesis of Human Bone Marrow- and Adipose Tissue-Derived Mesenchymal Stem Cells under Mechanical Stimulation
Correction: Biomarkers of professional cybersportsmen: Event related potentials and cognitive tests study
Research on computational propagation and identification of mine microseismic signals based on deep learning
In the mining field, hydraulic fracturing of coal - seam boreholes generates a large number of weak microseismic signals. The accurate identification of these signals is crucial for subsequent positio...
Cuts or carcasses? Diet form affects fecal microbial and animal fiber fractions in a large carnivore, the Asiatic lion
The care of exotic felids in zoos involves numerous factors, and the dietary management is currently considered particularly critical. This study investigated the effects of four different dietary reg...
Behavioural, immunological and transcriptomic consequences of post-weaning social isolation and chronic celecoxib administration in mouse
Early life stress (ELS) and chronic low-grade inflammation are associated with psychiatric disease risk, but their neurobiological consequences are poorly understood. Here, we aim to investigate the b...
Insights from the ground: A qualitative investigation of retailer perspectives of the challenges and opportunities in the legal cannabis market in Newfoundland and Labrador, Canada
Background The legalization of recreational cannabis in Canada has resulted in varying regulatory and market environments across provinces and territories. These differences shape...
Facial expression recognition reveals students’ engagement in online class: Correlations with six engagement measurements
Student engagement assessment in online learning faces critical limitations: traditional methods fail to capture engagement’s dynamic, multidimensional nature, particularly in second language (L2) con...
Fertilizer and fungicide reduce herbicide efficacy and enhance growth of invasive common tansy (Tanacetum vulgare)
Common tansy ( Tanacetum vulgare ; Asteraceae) is a widespread invasive species in North America that threatens biod...
Targeted pathogen profiling of ancient feces reveals common enteric infections in the Rio Zape Valley, 725–920 CE
DNA analysis of ancient, desiccated feces – termed paleofeces – can unlock insights into the lives of ancient peoples, including through examination of the gut microbiome and identification of specifi...
The ethical challenges in the integration of artificial intelligence and large language models in medical education: A scoping review
With the rapid development of artificial intelligence (AI), large language models (LLMs), such as ChatGPT have shown potential in medical education, offering personalized learning experiences. However...
Development of explicit definitions of potentially inappropriate prescriptions for antidiabetic drugs in people with type 2 diabetes: A Delphi survey and consensus meeting
Introduction Explicit definitions for potentially inappropriate prescriptions (PIPs) are useful for optimizing drug use. The objective of the present study was to validate a list o...
Analysis of intracellular and intercellular crosstalk from omics data
Disease phenotypes can be described as the consequence of interactions among molecular processes that are altered beyond resilience. Here, we address the challenge of assessing the possible alteration...