PLoS ONE
Articles in this Issue
An exploratory study on predicting HER2-positive expression status of breast cancer using ultrasound radiomics combined with machine learning models
Objective This study aimed to investigate the feasibility and potential value of predictive models for human epidermal growth factor receptor 2 (HER2)-positive status in breast can...
Gastric lavage may not be representative of total microplastic ingestion for a wild passerine bird
Microplastic pollution has become a global concern and understanding its impact on wildlife requires effective sampling techniques that quantify exposure. In particular, non-lethal sampling techniques...
Correction: Total proximal tibial osteotomy and cranial closing wedge ostectomy for treating concomitant medial patellar luxation and cranial cruciate ligament disease in dogs with excessive tibial torsion
Myasthenia gravis and autoimmune overlap: Prognostic insight
Background Autoimmune diseases (ADs) frequently coexist with myasthenia gravis (MG), suggesting shared genetic and immunological mechanisms. However, the impact of comorbid ADs on...
Alignment of PrEP adherence and HIV exposure risk among pregnant and postpartum women in Lilongwe, Malawi
Objective When measured continuously, adherence to HIV pre-exposure prophylaxis (PrEP) is consistently low in studies of pregnant and postpartum women. We investigated how PrEP adh...
Sliding mode dynamics of a non-smooth Filippov predator-prey system for integrated pest management
In recent years, the problem of pests seriously affects the yield and quality of crop, posing a major challenge to the safe production of crop, which have seriously hindered the development of China’s...
Polyadic synapses introduce unique wiring architectures in T5 cells of Drosophila
Connectomes provide neuronal wiring diagrams and allow for investigating the detailed synaptic morphology of each connection. In the visual system of Drosophila...
Auditory discrimination improvement in young adults by a digital auditory game-based training protocol
Auditory training is a technique that has demonstrated to be beneficial, improving auditory processing response as a supplement to hearing loss management. Recently, game-based training approaches hav...
Healthcare navigation services support access to gender-affirming care: A qualitative analysis of chat conversations
Background As transgender and gender diverse (TGD) people become increasingly visible, healthcare solutions in the United States have also expanded to meet their needs. As TGD peop...
Rising prevalence of parent-reported learning disabilities among U.S. children and adolescents aged 6–17 years: NSCH, 2016–2023
The prevalence of learning disabilities (LD) among children is a critical public health issue; however, recent LD prevalence estimates among children and adolescents aged 6–17 years, as reported by th...
ZPBP and fertility-associated proteomes as novel biomarkers: A shotgun proteomics approach in Murrah buffalo (Bubalus bubalis) bulls’ seminal plasma and cryopreserved spermatozoa
Comprehensive identification of seminal plasma and spermatozoa proteins is essential to understand sperm biology and the molecular mechanisms underlying bull fertility. In this study, we conducted a q...
Association between weight-adjusted waist index and chronic obstructive pulmonary disease
Objective This study aimed to investigate the association between the weight-adjusted waist index (WWI), a novel obesity metric, and the prevalence of chronic obstructive pulmonary...
Has the “green” transformation of the Common Agricultural Policy affected the environmental sustainability of farms?
This study aims to quantify the level of environmental sustainability in EU farms using a synthetic measure of the environmental burden in agriculture and to assess the overall effectiveness of the “g...
GIP/GLP-1RA as adjunctive to automated insulin delivery in adults with Type 1 diabetes (the AID-JUNCT trial): Study protocol for a prospective, randomized, clinical trial
Background Glycemic control in type 1 diabetes (T1D) remains a challenge, with 20−30% of adults achieving an A1c target of <7%. Glucagon-like peptide 1 receptor agonist (GLP-1 R...
Development of a new cell isolation device FlowMagicTM
Isolation of human peripheral blood mononuclear cells (PBMCs) from blood typically involves a density gradient medium during density centrifugation. The problem of increasing red blood cell (RBC) and...
Accurate measurement of simulated slow and altered walking activity: Apple Watch best in class wearable devices
Background Wearable activity devices, widely used to monitor physical activity in non-injured populations, have shown potential in encouraging early ambulation and enhanced recover...
Indirect associations of pain resilience and kinesiophobia with the relationship between physical activity and chronic pain
Background Pain is associated with a decrease in physical activity for most individuals. Nevertheless, some individuals manage to maintain physical activity levels despite pain. Wh...
Sexual orientation and gender identity data: An observational study assessing the feasibility of SOGI collection in clinical research and patient assistance programs
Purpose Sexual and gender minority (SGM) people often experience significant health disparities and poor health outcomes. The objective of this study was to assess the feasibility...
Maternal morbidity profile in hospitalizations in the Unified Health System in São Paulo, Brazil: Analysis using data mining, 2014 to 2019
In Brazil, approximately 80% of births are publicly funded and are registered in the Hospital Information System of the Unified Health System (SIH/SUS). The SIH/SUS has morbidity data, but its use for...
Plasma-activated media inhibits epithelial-mesenchymal transition and ameliorates intestinal fibrosis through the PPARγ/TGF-β1/SMAD3 pathway
Inflammatory bowel disease often complicates intestinal lumen stenosis, and intestinal fibrosis is the core pathological process leading to its development. Currently, there are no effective drug trea...
Type 2 diabetes remission and its predictors in an Indian cohort: A retrospective analysis of an intensive lifestyle intervention program
Predictors of type 2 diabetes (T2D) remission following intensive lifestyle intervention (ILI) are poorly characterized, especially in high-risk populations, such as India. This study aimed to identif...
A matter of size: Comparing IV and OLS estimates
Sizeable differences between OLS (Ordinary Least Squares) and IV (Instrumental Variables) estimates might be interpreted in the literature as evidence that the instrument is not valid. Yet, to the bes...
Design, simulation, and experimental study of hydrostatic drive system for wide-span farming platform
A versatile, robotic, and multi-functional wide-span farming platform, commonly known as a gantry tractor, can reduce soil compaction and enhance field production efficiency. In order to meet the func...
Designing a deposit-refund system for cigarette butts: What do smokers care about?
Cigarette butts (CBs) are the world’s most littered item and significantly contribute to environmental pollution. A deposit-refund system (DRS) has been proposed to reduce CB littering, but its effect...
Sex difference in the burden of rheumatic heart disease: Insights from the Global Burden of Disease Study 2021
Introduction Rheumatic heart disease (RHD) shows significant sex differences in disease burden. This study assesses these differences using data from the Global Burden of Disease S...