PLoS ONE
Articles in this Issue
Correction: Study on the releasing regularity of asphalt fume and its suppression technology
Anopheles barbirostris in Indonesia: A more complex metapopulation than expected
Anopheles barbirostris , a member of the Barbirostris Subgroup in the Anopheles genus, comprises a complex of species in South and Southeast...
Variation of metabolic and bariatric surgery utilization by neighborhood socioeconomic status in Maryland
Importance Metabolic and Bariatric Surgery (MBS) is a proven treatment for severe obesity, yet disparities in its utilization persist, particularly among socioeconomically disadvan...
Health risk assessment of heavy metals in arid soils of the Nile Delta, Egypt using GIS and multivariate statistical analyses
Economic expansion has led to an increase in new toxins in the environment, creating a global problem for managing both environmental and human health. This study aimed to quantify the concentration o...
Elucidation and application of the neuroimmune axis between depression and autoimmune diseases: A genome wide and cohort study
The neuroimmune axis, a critical communication network between the nervous and immune systems, has been implicated in the comorbidity of depression (DeP) and autoimmune diseases (ADs). The shared gene...
Integrative machine learning and multi-omics framework identifies shared biomarkers for rheumatoid arthritis and ulcerative colitis
Background Rheumatoid arthritis (RA) and ulcerative colitis (UC) are chronic inflammatory diseases with shared immune pathologies but limited common diagnostic biomarkers, which hi...
Investigating the causal effect of maternal continuum of care on child’s minimum acceptable diet: A multilevel approach using partially pooled propensity score weighting
Malnutrition contributes to half of child mortality in low- and middle-income countries like Bangladesh. It’s challenging for a developing country to improve child nutrition using limited resources an...
Developing and validating a clinical prediction model to predict epilepsy-related emergency department attendance, hospital admission, or death: A cohort study protocol
Introduction This retrospective open cohort study develops and externally validates a clinical prediction model (CPM) to predict the joint risk of two important outcomes occurring...
Insufficient impact of the aldose reductase inhibitor cemtirestat on the skeletal system in type 2 diabetic rat model
Cemtirestat, a multi-target drug combining aldose reductase inhibition with antioxidant properties, is considered a promising therapeutic agent for chronic diabetic complications. Current evidence sug...
Network pharmacology and experiments verify the effect of triptolide on extraocular muscle fibrosis
Drugs usually do not prevent extraocular muscle fibrosis in Graves’ ophthalmopathy (GO), and surgical treatment has complications and does not cure extraocular muscle fibrosis. Triptolide (TPL) has sh...
Retraction: Dynamics of natural product Lupenone as a potential fusion inhibitor against the spike complex of novel Semliki Forest Virus
Railway fastener defect detection using RFD-DETR: A lightweight real-time transformer-based approach
Railway fasteners play a crucial role in ensuring track stability and safety; however, manual inspection is both inefficient and prone to errors. Deep learning models, such as YOLO, are widely utilize...
A brief, theory-driven patient education video reduces high-risk over-the-counter nonsteroidal anti-inflammatory drug (NSAID) use
Professional guidelines advise against regular or long-term NSAID use in most patients with chronic kidney disease (CKD), heart failure (HF), and hypertension (HTN) due to risk of adverse events. Neve...
A robust machine learning approach for DC bias prediction in DCO-OFDM based Li-Fi systems
The direct current (DC) in optical orthogonal frequency division multiplexing (DCO-OFDM) scheme is commonly adopted in light fidelity (Li-Fi) technology as it offers a spectrally efficient solution. A...
Physician payment models and cardiac imaging in patients at low cardiovascular risk: A population-based cohort study in Alberta, Canada
Background Many factors beyond patient need influence the care that patients receive, including the way physicians are paid, and how services are delivered. In Alberta, outpatient...
Establishing a dementia care competency framework for care partners, health and social care providers: A modified Delphi study protocol
Dementia care requires a wide range of knowledge and skills delivered by both unpaid care partners and health and social care providers. In Ontario, Canada, no systematic framework currently aligns ed...
Predicting in-hospital mortality in children in low- and middle-income countries: A systematic review and meta-analysis of vital signs and anthropometric measurements
Background In low- and middle-income countries (LMICs), child mortality rates remain substantially higher compared to high-income countries, with many deaths preventable through ea...
Efficacy and safety of polymer-free amphilimus-eluting stent in patients with and without diabetes mellitus: A prospective, multicenter observational study
Background Patients with diabetes mellitus (DM) undergoing percutaneous coronary intervention face higher risks of restenosis and adverse cardiovascular outcomes compared to those...
Risk factors and management of medical disputes: An analysis of preliminary appraisal reports
Background Medical disputes represent a growing challenge in healthcare, with implications for patient safety, legal liability, and institutional trust. Identifying contributing fa...
Multi-modal inflammatory risk modeling in post-PCI patients using behavioral and physiologic data
Background Persistent low-grade inflammation following percutaneous coronary intervention (PCI) is a known contributor to major adverse cardiovascular events (MACE). While biomarke...
Work-related stress in intensive care unit night shift nurses: A cross-sectional analysis of prevalence and determinants
Background Night-shift ICU nurses are highly vulnerable to work-related stress, impacting performance, patient safety, and burnout risk....
Evaluation of MoveSmart MS - an online structured exercise, Social Cognitive Theory-based behavioural coaching and peer support programme - on anxiety in multiple sclerosis
Background Anxiety is a common experience among people with multiple sclerosis (PwMS). While it is known that engaging in exercise has a number of benefits, the role played by exer...
Paleontological and paleoecological significance of the oldest highly productive Upper Cretaceous (lowermost Maastrichtian) bonebed of Haţeg Basin (western Romania; Densuş-Ciula Formation)
Recent extensive fieldwork in the Densuş-Ciula Formation in Haţeg Basin has led to the discovery of several important high-diversity bonebeds. Among the excavated locations, site K2 is by far the most...
Molecular and evolutionary determinants for protein interaction within a class II aldolase/Adducin domain
The appearance of modular protein interaction domains represents a crucial step in the evolution of multicellularity. For example, the class II aldolase domain (ALDO DOM...
Wealth creation and disease burden: Evidence from Nigeria based on a Bayesian-VAR approach
Does wealth creation reduce disease burden for developing countries? In this paper a Bayesian-VAR (B-VAR) model is built to investigate the causal relationships between disease burden, wealth creation...