PLoS ONE
Articles in this Issue
Spatiotemporal disparities in the diagnosis, treatment, and mortality of respiratory tract cancers in Brazil
Purpose This study aimed to assess spatiotemporal disparities in the diagnosis, treatment, and mortality rates of respiratory tract cancers (RTCs) in Brazil....
EMSA: Explainable multilingual sentiment analysis models providing sentiment analysis across multiple languages
Sentiment analysis across multiple languages remains a challenging problem due to linguistic diversity, domain-specific expressions, and the limited explainability of existing models. This study aims...
Lonely and connected in emerging adulthood: The ambivalence of sociality in a time of transitions
Utilizing a large, representative sample of Americans ( N = 4,812), the present manuscript explores individuals’ ag...
Self-compassion, well-being, and body image concern in young Japanese women: The role of positive and negative facets of self-compassion
The present study comprised two studies to examine how decreasing the negative facet of self-compassion, in addition to increasing its positive facet, is associated with body image and well-being in y...
Predicting the risk of asthma development in youth using machine learning models
Asthma is a chronic respiratory disease characterized by wheezing and difficulty breathing, which disproportionally affects 4.7 million children in the U.S. Currently, there is a lack of asthma predic...
Improved noise reduction for nonlinear PMDC motor dead zone and friction model using variants of extended Kalman filter with practical validation
An improved framework for measurement noise reduction of nonlinear PMDC motor using variants of extended Kalman filter (EKF) is presented in this paper. Simulatory as well as experimental testing and...
In silico structural analysis of Oryza sativa RAD51 reveals key interactions for nucleoprotein filament assembly and regulation
Radiation sensitivity 51 (RAD51) is important for homologous recombination and DNA repair. The interaction between BRCA2 and RAD51 is crucial for the successful repair of DNA double strand breaks by h...
Foundations of climate change denial: Anti-environmentalism and anti-science
Despite a longstanding scientific consensus about the reality of anthropogenic global warming (AGW), a climate change countermovement (CCCM) has worked to undermine and cast doubt on climate science f...
Improved CRISPR/Cas9 off-target prediction with DNABERT and epigenetic features
CRISPR/Cas9 is a powerful genome editing tool, but its clinical application is hindered by off-target effects. Accurate computational prediction of these unintended edits is crucial for ensuring the s...
Understanding barriers and facilitators of inter-organizational dynamics in addressing substance use disorder among pregnant and parenting women
Background Pregnant and parenting women with substance use disorders (SUDs) face complex and overlapping challenges, including substance use, legal issues, housing instability, and...
Optimization of ecological restoration efficiency in Qinghai-Tibet Plateau using the Cubist regression tree model: A study of environmental adaptability models
This study addresses the inefficiencies in ecological restoration on the Qinghai-Tibet Plateau (QTP), particularly concerning prolonged vegetation restoration cycles, slow soil quality improvement, an...
Long-term impact of battle injuries; Ten-year follow-up of Dutch servicemembers injured in Afghanistan
Background Our five-year follow-up of injured service members deployed to Afghanistan showed that battlefield casualties (BCs) experience lower quality of life and higher distress...
Glass factory found: Basinwide (600 km) preservation of sponges on the Phosphoria glass ramp, Permian, USA
A new analysis of misdiagnosed fossil deposits contextualizes the geologic origin for one of North America’s most valuable, but enigmatic, sedimentary units: the Phosphoria Rock Complex (Permian). We...
Neglected risks in the Chinese insurers’ misconduct caused by digitalization
Digital transformation offers opportunities for innovative growth while also introducing emerging risks of misconduct in the insurance industry. This study examines the impact of digital transformatio...
Repeated application of transcranial ultrasound maintains spatial and recognition memory in 5xFAD mice with reduction of amyloid-β burden
Pharmacological removal of amyloid beta protofibrils has emerged as a promising therapeutic strategy to delay the onset of Alzheimer’s disease (AD) symptoms. As a non-pharmacological and noninvasive a...
PIM1 induces hypoxia-related fibroblast senescence in a mouse model of stress urinary incontinence
Objective This study aims to explore the contribution of PIM1 kinase-mediated cellular senescence to the pathogenesis of stress urinary incontinence (SUI) and to assess the therape...
Impact of active tuberculosis on social mobility and its gender differences: Difference in differences using nationwide tuberculosis surveillance data and national health insurance data
Although reducing catastrophic total costs caused by TB is a major public health concern, there is a scarcity of long-term follow-up studies on social suffering due to TB as well as studies examining...
Regional asymmetry in financial markets: Pricing of skewness risk in the Thai stock market
This study examines the role of skewness as a priced risk factor in the Thai stock market, drawing on both rational and behavioral asset pricing theories. Theoretically, skewness captures return asymm...
A composite metric for evaluating system resilience with non-idealistic performance curves
Designing systems and processes resilient to sudden shocks is an essential element of system analysis in many engineering fields. Quantitative resilience assessment employs various metrics to examine...
Offline and online coupled tensor factorization with knowledge graph
How can we accurately decompose a temporal irregular tensor along while incorporating a related knowledge graph tensor in both offline and online streaming settings? PARAFAC2 decomposition is widely a...
Automatic uterus segmentation in transvaginal ultrasound using U-Net and nnU-Net
Purpose Transvaginal ultrasound (TVUS) is pivotal for diagnosing reproductive pathologies in individuals assigned female at birth, often serving as the primary imaging method for g...
Aerobic exercise improved liver steatosis by modulating miR-34a-mediated PPARα/SIRT1-AMPK signaling pathway
MicroRNA-34a (miR-34a) was closely associated with liver steatosis. However, the link between changes in miR-34a and the progression of liver steatosis remained unclear. In the work, sixty mice were r...
Open science practices among early-career human-computer interaction researchers in the US
Many fields of science have heightened introspection in the wake of concerns around reproducibility and replicability of published findings. In recent years, the Human-Computer Interaction (HCI) commu...
Prevalence of clinically significant refractive error in children in Europe: Systematic review and meta-analysis
Purpose This meta-analysis estimated clinically significant refractive error prevalence in European children and examined variations based on cycloplegic versus non-cycloplegic ref...
The assessment and predictive factors of posttraumatic stress and growth in mothers of young children with genetic conditions: A protocol for a longitudinal study
Introduction Diagnosing a child’s disease is a traumatic event that impacts parents’ psychological well-being and mental health and is associated with burden. This protocol of a lo...