PLoS ONE
Articles in this Issue
Comparing the impact of systemic pituitary adenylate-cyclase-activating polypeptide (PACAP) and calcitonin gene-related peptide (CGRP) on motion-induced nausea and balance behaviors in mice
Pituitary adenylate-cyclase-activating polypeptide (PACAP), particularly its dominant isoform PACAP-38, is implicated in migraine and represents a promising therapeutic target. We investigated if intr...
Silent spread of mcr-9 in ESBL-producing Enterobacteriaceae clinical isolates, Jimma, Ethiopia
Background Mobile colistin resistance (MCR) genes, have been increasingly identified worldwide, but their presence and characteristics in Africa remain poorl...
In silico design of a multi-epitope vaccine against Cryptosporidium parvum using structural and immunoinformatics approaches
Background Cryptosporidium parvum is a waterborne protozoan parasite responsible for diarrheal illness in humans and animals. The lack...
Expectations for Mendelian randomization research in PLOS One
Academic motivation, procrastination, and adjustment: Exploring their impact on student profiles and academic performance
Introduction Succeeding in entering higher education studies is influenced by motivation, procrastination, and how well students adjust to university life. By understanding these f...
Exploring cardiovascular disease prevalence and contributing factors among adults in Southern Iran, a cross-sectional survey: Rationale, design, and primary results
Background and objectives Cardiovascular disease (CVD) is the primary cause of death worldwide, with significant fatalities reported in Iran. Hormozgan Province in southern Iran fa...
Assessment of medication review among pharmacy professionals in the UAE: A cross-sectional study on knowledge, attitudes, practices, and barriers
Background Medication reviews are vital for optimizing patient care and resolving drug-related problems, with pharmacists playing a key role. Understanding pharmacists’ knowledge,...
Effects of SGLT-2 inhibitors on renin-angiotensin-aldosterone system and their correlation with glucose metabolism in type 2 diabetes mellitus patients with hypertension: A prospective study
Background The impact of sodium-glucose cotransporter-2 inhibitors (SGLT-2is), including dapagliflozin, on the renin-angiotensin-aldosterone system (RAAS) in type 2 diabetes mellit...
Correction: Tracking Enterobacteria, microbiomes, and antibiotic resistance genes from waste to soil with repeated compost applications
NLRP3 inflammasome-dependent and -independent interleukin-1β release by macrophages exposed to wear and corrosion products from CoCrMo implants
Wear particles and metal ions released from cobalt–chromium–molybdenum (CoCrMo) implants can trigger adverse local tissue reactions (ALTR) that can lead to implant failure. Identifying mechanisms invo...
Editorial Note: Assessment of time management practice and associated factors among primary hospitals employees in north Gondar, northwest Ethiopia
Factors related to mortality in patients with acute respiratory distress syndrome (ARDS) in a lower middle-income country: A retrospective observational study
Background Acute respiratory distress syndrome (ARDS) is associated with a high mortality rate, particularly in low- and middle-income countries, where the quality of pre-hospital...
Agile cyber defense: Enhancing digital substation resilience with SDN-based smart switching
This paper provides an evaluation methodology and prototyped and tested a virtual Intelligent Electronic Device (vIED) for digital substations in a Real Time (RT) simulation. Based on the IEC 61850 st...
Influence of exercise commitment on exercise adherence among undergraduate students: Chain mediation role of health beliefs and exercise behavior
This study probed into the correlation between exercise commitment and adherence among undergraduate students and expounded on the mediating role of health beliefs and exercise behavior. A questionnai...
Going viral: How social and personal motivations drive emotional engagement and consumer online brand-related activities
In today’s digital marketing landscape, viral brand campaigns succeed when consumers actively engage with and share brand messages across their social networks. Building on social exchange theory, thi...
What constitutes ‘poor’ adherence to medical advice for chronic diseases? Insights from a qualitative study among hypertension and diabetes patients in urban informal settlements, Mumbai Metropolitan Region
Introduction The problem of poor adherence to medical advice in the case of non-communicable diseases, the reasons thereof, and how these are exacerbated in low- and middle-income...
SegCycle-SPADE: An end-to-end framework for semantic segmentation-based automated extraction and artistic reconstruction of traditional craft patterns using conditional GAN
This paper addresses the challenge of traditional handicraft pattern extraction and generation, focusing on accurate segmentation and high-quality pattern reconstruction. We propose the SegCycle-SPADE...
PPI-based screening of hub genes related to sepsis migration/pyroptosis and immune infiltration analysis
Background Sepsis incidence is rising, but its pathogenesis remains unclear. This study aimed to identify therapeutic targets....
Supportive care needs and challenges experienced by women diagnosed with breast cancer in Kumasi, Ghana: A qualitative exploratory study
Introduction Globally, breast cancer (BC) remains the main cause of illness and death among women. A diagnosis with BC can be emotionally devastating and draining and these could p...
Genetic diversity analysis of wild tea plant resources in Chongzuo based on phenotypic traits and SSR molecular markers
To explore the genetic diversity of wild tea plants, the methods of the phenotypic traits and SSR molecular marker analysis were adopted to analyze the 40 samples of 7 wild tea populations in Chongzuo...
Epidemiological trends in alcoholic cardiomyopathy burden: A 32-year global and Chinese analysis (1990–2021) with projections to 2036
Background: Alcoholic cardiomyopathy (ACM), a preventable yet overlooked cardiomyopathy subtype, disproportionately affects chronic alcohol users through alcohol-induced myocardial...
Association of hyperuricemia with coronary heart disease and other cardiovascular outcomes: A systematic review and dose-response meta-analysis
Introduction Uric acid (UA) is considered as a potential risk factor for coronary heart disease (CHD) and other cardiovascular diseases (CVDs). However, the association between hyp...
Correction: Estimating recent HIV incidence among young men who have sex with men: Reinvigorating, validating and implementing Osmond’s algorithm for behavioral imputation
Towards personalized recommendation with enhancing preference matching through scene-weighted reranking
Reranking is crucial in recommendation systems, refining candidate lists to significantly enhance the matching of user preferences and encourage engagement. While existing algorithms often focus solel...
Demand forecasting and inventory optimization of distribution equipment: A fusion model based on genetic algorithm and machine learning
To improve the intelligent and refined management level of power distribution systems in equipment operation and maintenance as well as emergency support, this work proposes an integrated “prediction-...