PLoS ONE
Articles in this Issue
FOXO1 transcription factor modulates airway epithelial responses to viral infection
The airway epithelium serves as the initial barrier of defence in the respiratory system, guarding against microbial, chemical, and environmental threats introduced through inhaled air. Pattern recogn...
Anti-hepatocellular carcinoma activity of Jacaranda mimosifolia through experimental validation and network pharmacology
Hepatocellular carcinoma (HCC) has a very significant mortality rate and is one of the most common cancers worldwide. Jacaranda mimosifolia is reported to have...
Reliability analysis of horseshoe tunnels by radial-based importance sampling method based on complex function displacement solution
Tunnel reliability analysis is an important analytical method to ensure tunnel safety. In this paper, the plane elastic complex variable function theory is adopted, and the explicit displacement funct...
Study on the therapeutic effect of eggshell membrane on osteoarthritis in rats
This study aimed to investigate the therapeutic effects of ELASEM ® Flex and ELASEM ® ProFlex, two eggshell membrane (EM...
Benchmarking free energy calculations: Analysis of single and double mutations across two simulation software platforms for two protein systems
Mutation analysis of single and double mutations of proteins including the two widely studied proteins: Staphylococcus nuclease (S. nuclease) and T4 lysozyme, provides critical insights into their sta...
(Re)defining urban villages and their potential in sustaining local authenticity: A case study of Da Lat, Viet Nam
Urban villages have been theorised in three dominant ways: as ethnic enclaves in migration studies, as the UK Urban Village Concept, and as villages-in-the-city in the Global South. Whether these inte...
hUMSCs-exo@Cyasterone protects the cell model of steroid-induced femur head necrosis by regulating N-glycosylation modification of CTSD-N258A
Objective It has been demonstrated that both hUCMSC-exo and Cyasterone exhibit protective effects against steroid-induced osteonecrosis of the femoral head (SIONFH). Additionally,...
Spatiotemporal prediction of mining-induced surface subsidence using integrated D-InSAR and boltzmann time function models
With the expansion of underground coal mining, accurate prediction of surface subsidence dynamics has become increasingly critical. This study proposes a hybrid prediction framework integrating Differ...
Beyond the emergency: Centering mental health in community disaster preparedness and recovery
Background Extreme weather events are increasing in frequency and severity, disproportionately affecting marginalized and under‑resourced communities. In Houston, Texas, where insu...
Comparative evaluation of machine learning models for predicting Cimbex quadrimaculata population density across multiple problem formulations
The high variability and nonlinear relationships between environmental variables (such as temperature, relative humidity, and altitude) in ecological datasets prevent classical statistical models from...
Real-world safety of aliskiren in primary hypertension: A cross-database study
Hypertension is one of the main causes of cardiovascular diseases worldwide, affecting over one billion people. Although aliskiren offers a valuable option for inhibiting the renin-angiotensin system,...
Utilizing the transformer mechanism to predict cervical lymph node metastasis in patients with papillary thyroid carcinoma
Rationale and objective The status of cervical lymph node metastasis(LNM) in Papillary thyroid carcinoma(PTC) can affect the patient’s treatment plan and prognosis. This study aims...
Lactobacillus casei culture supernatant ameliorates acute alcohol-induced liver injury by inhibiting cellular stress and promoting intestinal integrity in mice
Alcohol-associated liver disease (ALD) is a common liver disease worldwide. Probiotics prevent alcohol-induced liver injury and improve intestinal integrity. However, the precise mechanisms behind the...
Associations between area-level socioeconomic disadvantage and COVID-19 disease consequences in Sydney, Australia: A retrospective cohort analysis
Background Socioeconomic disparities have shaped COVID-19 outcomes worldwide. Focusing on disease consequences once infected (severity among cases), we examined whether area-level...
The transition from winter to spring has an impact on the airway metabolome profile of asthmatic horses
Equine asthma is a chronic, non-infectious inflammatory disease of the lower airways in horses, classified as mild to moderate (MEA) or severe (SEA). Its pathogenesis is not fully understood and is in...
Resilience of anaerobic digestion to polypropylene microplastic contamination: Kinetic and structural evidence
The increasing occurrence of microplastics (MPs) in organic waste streams raises concerns about their impact on anaerobic digestion (AD). This study examined the effect of polypropylene MPs (PP-MPs) o...
VLM-Nav: Mapless UAV navigation using monocular vision driven by vision-language models
Autonomous vehicles, such as Unmanned Aerial Vehicles (UAVs), have the potential to completely reshape various industries such as parcel delivery, agriculture, surveillance, monitoring, and search-and...
Identifying researcher characteristics driving growth in Japanese University-originated deep-tech startups: A machine learning approach
Active involvement of researchers with strong outputs is essential for growth of deep-tech university-originated startups. We used the University-Originated Venture Database to link total funding amou...
Facilitators and barriers to compliance with a raw coal ban amongst pregnant women and mothers of young children in Ulaanbaatar, Mongolia: A mixed-methods study
Ulaanbaatar, Mongolia, is in the midst of a winter air pollution crisis driven by the combustion of solid fuels in the peri-urban Ger districts to which young children, fetuses and pregnant women are...
Correction: From meat to raw material: the Middle Pleistocene elephant butchery site of Casal Lumbroso (Rome, central Italy)
Technostress, psychosocial safety climate, and worker well-being in automated manufacturing: A two-wave study
The rapid digitalization of manufacturing has introduced new psychosocial risks alongside productivity gains, particularly in the form of technostress. This study investigates how technostress influen...
A genomic locus uniquely encoded by blueberry-infecting Xylella fastidiosa strains affects motility and biofilm formation in vitro, and virulence in planta
Xylella fastidiosa ( Xf ) is an insect-transmitted, xylem-limited bacterial plant pathogen that infects hundreds of plant species. This path...
Association of the 24-hour movement behaviours composition with workers’ chronic musculoskeletal pain
Background Chronic musculoskeletal pain is a significant symptom among workers. 24-hour movement behaviours comprising sleep, sedentary behaviour, light-intensity physical activity...
Pan-cancer landscape of protein kinase D3: An integrative TCGA multi-omics analysis of clinical, molecular, and immunological roles
Cancer remains a leading cause of mortality worldwide and a significant barrier to improving quality of life across all populations. The protein kinase D family, including PRKD3...
Protocol for a study on the mental health and well-being of “Forgotten” first responders in Canada
In addition to traditional first responders such as police, firefighters, and paramedics, there are many other workers who carry an occupational responsibility to respond to trauma. Such professions i...