PLoS ONE
Articles in this Issue
Editorial Note: Prevalence of Chinook salmon is higher for southern than for northern resident killer whales in summer hot-spot feeding areas
Sickle cell disease and maternity care: A qualitative synthesis of women’s and health providers experiences
Introduction Sickle Cell Disease (SCD) is one of the most prevalent genetic diseases in the world. For women with SCD or those with Sickle Cell Trait (SCT) reproductive choices not...
Triggering of viral and bacterial respiratory infection hospitalizations by traffic pollution exposure in a cohort of hospitalized adults
The rate of respiratory viral infection (RVI) associated with acute air pollution exposure is well established, but whether bacterial and viral infections respond similarly to traffic related air poll...
Optimization of low-carbon multi-temperature joint distribution for fresh agricultural products under 3D loading constraints
With the growing demand for fresh agricultural products, improving the efficiency and sustainability of cold-chain distribution has become increasingly important. Multi-temperature joint distribution...
Comparison of Moducare versus Wait-and-See approach for histologically proven Low-grade Cervical Intraepithelial Neoplasia (CIN1) (MODUCIN1 TRIAL) – Study protocol
Human Papillomavirus (HPV) is causally associated with cervical cancer and precancerous lesions (dysplasias) of the cervix. The treatment of choice for low-grade lesions is monitoring with no-treatmen...
Evolving optimal text clusters: A novel GA-driven framework for dynamic ensemble fusion of multi-model contextual embeddings
Text clustering is an essential activity in unsupervised natural language processing (NLP), and allows the automatic structure of large-scale textual collections (in natural language processing) in ne...
Transcriptomic characterization of key psoriasis-associated genes based on single-cell RNA-seq and machine learning
Background Psoriasis is a multifaceted skin and systemic disorder driven by a complex interplay of genetic, immunological, and environmental factors. Genetic predisposition plays a...
The effects of continuous chest compression protocol on cardiopulmonary resuscitation (CPR) quality and fatigue
Aim This study investigated how fatigue (measured both subjectively and objectively) and cardiopulmonary resuscitation (CPR) quality are impacted by various CPR protocols, principa...
Tool choice matters: Evaluating edgeR vs. DESeq2 for sensitivity, robustness, and cross-study performance
Differential gene expression (DGE) analysis is foundational to transcriptomic research, yet tool selection can substantially influence results. This study compares two widely used DGE tools,...
A dual-stream deep learning architecture for business impact scoring and alert escalation
Modern network monitoring systems generate massive volumes of telemetry data, yet most existing anomaly detection models fail to prioritize alerts according to their operational urgency and business i...
Structural equation modeling for exploring the barriers to accessing healthcare among hijra in Bangladesh
Introduction Hijra in Bangladesh and other South Asian countries face considerable barriers to healthcare given their potential exposur...
Mapping global inequities in telemedicine implementation: An umbrella review of barriers and facilitators
Telemedicine expanded rapidly during the COVID-19 pandemic, yet its diffusion has remained uneven across health systems. Whether implementation challenges differ systematically across economic context...
Genome-wide characterization of copy number variants and their functional relevance in indigenous draught cattle of South Asia
Copy number variations (CNVs) are an important source of structural genomic variation and contribute to phenotypic diversity in cattle, including traits related to production, reproduction, and adapta...
Assessment of simulation-based inference methods for stochastic compartmental models in epidemiological research
Global pandemics, such as the recent COVID-19 crisis, highlight the need for stochastic epidemic models that can capture the randomness inherent in the spread of disease. Such models must be accompani...
Effects of walking training with blood flow restriction on the hemodynamics and perceptual responses among sedentary college students: A randomized crossover trial
College students often present a sedentary lifestyle. Low-intensity walking training with blood flow restriction (WT-BFR) may offer health benefits comparable to moderate-to-high intensity walking tra...
Strategies for implementing genomic selection in a public soybean breeding program
Improving selection accuracy in soybean breeding programs is crucial for reducing costs and shortening the time required to develop new varieties. Genomic selection (GS) is a promising tool for enhanc...
T-pGNN4DTI: Towards better drug-target interactions prediction using Global Self-attentive Pooled Graph Convolutional Networks and protein pre-training Models
Identification of drug-target interactions (DTI) is an important and challenging task in drug discovery and development. Traditional methods generally require biological experiments, which are costly...
The impact of pectin supplementation on systemic inflammation pathways, gut microbiome, and metabolic health in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A study protocol for a randomised controlled trial
Background Metabolic dysfunction–associated steatotic liver disease (MASLD) is the leading cause of chronic liver disease, affecting over 30% of adults worldwide. Emerging evidence...
Correction: Long-term potentiation and neurotransmitters expression and segregation are altered in the Metabolic Syndrome-associated dysautonomia
Capturing women’s bodily experiences: Conception and formative stages of the women’s somatic experience inventory
Assessment of women’s bodily experiences is used primarily to characterize negative psychological features of menstruation. However, women’s somatic states span a full spectrum of valence, emanate fro...
Germline-mediated ubiquitous recombination in ScxCre male mice: Implications for tendon research
Scleraxis (Scx), a basic helix-loop-helix (bHLH) transcription factor, is a primary marker for tendon and ligament lineages. Accordingly, mouse models utilizing Cre recombinase under the control of th...
The influence of hand depiction types on behavioural patterns in laterality judgments
According to Motor Simulation Theory, cognitive states such as kinesthetic motor imagery activate the motor system in a manner similar to overt motor execution. Action simulation can be implicitly tri...
Association between pre-birth waist circumference and neonatal size and health in mother-newborn pairs in Lausanne, 1917–1921
Background Maternal anthropometric dimensions influence neonatal size and survival, yet waist circumference measured shortly before delivery remains little studied. Using historica...
Bacterial diversity, quantitative risk assessment of spring waterborne pathogens and their biocontrol through phyto-biosorbents
Bacterial contamination of drinking water is a significant cause of water-borne illnesses in many developing countries, where water sources are commonly shared by the community. Therefore, the recent...
Genomic surveillance of carbapenem-resistant Acinetobacter baumannii from bloodstream infections in Thailand reveals widespread dissemination of blaNDM–harboring mobile genetic elements
Carbapenem-resistant Acinetobacter baumannii (CRAB) is a major cause of hospital-acquired bloodstream infections in Thailand, with limited treatment options and...