Science
Articles in this Issue
Local signals, systemic decline
A high-fat diet affects tumor-to-nerve signaling and promotes cachexia in mice
Transparent fish takes center stage in $1 billion neuroscience initiative
The once-obscure Danionella fish will be the focus of an ambitious new Howard Hughes Medical Institute project
Alternating atomic-dipole layers and switching dynamics in Al <sub>1-x</sub> Sc <sub>x</sub> N ferroelectrics
Wurtzite Al 1-x Sc x N ferroelectrics exhibit exceptional polarization and thermal stability, making them highly promisi...
Orbital magnetoresistance in the antiferromagnet CoO driven by dynamic orbital angular momentum
Recent predictions of orders of magnitude larger orbital current effects compared with spin currents have attracted considerable interest. However, orbital currents must first be converted into spin c...
Continental breakup–driven uplift instigated East Antarctic Ice Sheet formation
Why Antarctica became glaciated ∼34 million years ago (Ma) remains debated, as relatively warm climates and sea temperatures appear inconsistent with ice sheet formation. Although a critical decline i...
The invisible hand
Microbiota have a hidden role in mosquito-borne disease
Observation of quantum vortex core fractionalization and skyrmion formation in a superconductor
Magnetic fields can penetrate a superconductor in the form of quantum vortices, which consist of a core singularity with circulating currents. London’s quantization implies that there is one core sing...
From Edison’s Invention Factory to the new architecture of innovation
Shifts reflect the maturation of institutions surrounding science
Computing in a memory with physics
An artificial neural network built into a computer memory chip reconstructs the human cortex with high accuracy in real time
NIH security rules for genomic data sets are slowing research
Data security experts say increased oversight is needed, but researchers are struggling to comply
Erratum for the Research Article “Detecting supramolecular organic nanoparticles during heat wave”
NIH again faces year-end grantmaking scramble
Despite delays and staff shortages, agency should be able to fully spend 2026 budget, but new grants will likely remain below historic levels
Feeling a chill
The Norwegian archipelago of Svalbard has become a key outpost for Arctic science. But geopolitical tensions are complicating research efforts
Zonated mechanosensing by PIEZO1 controls liver regeneration
The liver exhibits a marked regenerative capacity organized through distinct zones, yet how tissue mechanics coordinate zonated proliferation remains elusive. We reveal that mechanical cues critically...
250 years of promise
America has for its entire history been fascinated with science. Although the lofty ideals associated with establishing the country have mostly to do with personal liberty and equality, the founders w...
Family stability sustains scientific talent
Surface immune signaling unlocks NLR activation through mRNA alternative splicing
Plants activate pattern-triggered immunity (PTI) and effector-triggered immunity (ETI) to combat pathogens. However, how these systems coordinate immune activation while preventing autoimmunity remain...
Johns Hopkins University and the American research enterprise
The nation’s research universities have traced an indelible path through the American story
A sub–10-millisecond neural dynamical system based on phase-change memristors
High-fidelity geometry for physical-world modeling demands real-time, dense, and differentiable deformation fields on manifolds. Neural dynamical systems (NDSs) using adaptive stepsize integration wit...
The mechanics of liver regeneration
A mechanosensitive ion channel regulates liver cell proliferation after injury
ILC2s regulate a fibroblast progenitor niche in the pancreas
Local fibroblast development and densities influence organ health and disease, although it remains unclear how tissue fibroblast topography is controlled in situ. Here, we defined Group 2 innate lymph...
End “reusable” waste dumping in Africa
How an ancient continental breakup ultimately helped spawn the vast Antarctic Ice Sheet
Mantle waves and tectonic stretching lofted polar mountains into a deep freeze
TranscriptFormer: A generative cell atlas across 1.5 billion years of evolution
Single-cell transcriptomics is revolutionizing our understanding of cellular diversity, yet comparing transcriptional programs across the tree of life remains challenging. We developed TranscriptForme...
Rubin telescope begins a 10-year movie of the cosmos
Giant camera will repeatedly scan the sky, spotting transients while building deep map of billions of galaxies