Science
Articles in this Issue
Spatially resolved single-cell atlas reveals the macroevolutionary trajectory of animal hearts
Animal hearts display diverse anatomical structures during adaptive evolution. Here, we present a multi-omics atlas of adult hearts from 27 species across chordates, arthropods, and mollusks. Joint an...
Programmable design of synthetic plant immune receptors for pathogen protein recognition
The limited diversity and recognition scope of natural plant immune receptors impede resistance breeding against rapidly evolving pathogens. Here we report programmable design of synthetic plant immun...
A cinnamyl alcohol dehydrogenase–like scaffold organizes monoterpenoid indole alkaloid biosynthesis
Biosynthesis of ~3,000 monoterpenoid indole alkaloids (MIAs), including the anticancer drug vinblastine, involves the highly unstable intermediate strictosidine aglycone. Its formation by strictosidin...
Helium escaping from the atmosphere of a nearby rocky exoplanet orbiting in a habitable zone
Observations of highly irradiated gas giant exoplanets have shown helium escaping from their atmospheres. There is limited evidence for atmospheres on rocky exoplanets, perhaps because they have alrea...
De novo design of orthogonal far-red, orange, and green fluorophore-binding proteins for multiplexed imaging
Fluorescent proteins and small-molecule dyes offer complementary advantages for biological imaging: proteins are amenable to genetic tagging, whereas dyes provide superior brightness and photostabilit...
Preferred synthesis of armchair transition metal dichalcogenide nanotubes
Nanotubes represent an important class of crystalline materials but controlling their structures, particularly chiralities, remains a fundamental challenge. In this work, we report a strategy for synt...
Autonomous biomedical research with an artificial intelligence agent
Biomedical research is increasingly constrained by repetitive, fragmented workflows that slow discovery. We introduce Biomni, a general-purpose biomedical artificial intelligence agent that autonomous...
Vicinal disubstitution of alkyl C–X synthons via alkene radical cation generation
In organic chemistry, functionalization of two adjacent carbons often starts from alkenes or already disubstituted precursors. Herein, we report an exergonic activation mode that directly generates al...
Virome-wide ubiquitin ligase discovery reveals diverse mechanisms of immune evasion
Viruses are intracellular parasites that reprogram the host proteome to promote replication and evade immune recognition. We applied a virome-wide library of ~10,000 open reading frames to discover vi...
Bacteria sense virus-induced genome degradation via methylated mononucleotides
Phages often degrade the genome of their bacterial host to individual nucleotides. Here we describe Metis, a bacterial defense system that directly senses phage-mediated host genome degradation. Metis...
TTF2 processes sites of incomplete DNA replication during mitosis via sister-chromatid exchanges
Mammalian cells frequently enter mitosis before DNA replication has finished, necessitating the rapid processing of unreplicated loci to facilitate chromosome segregation. The TRAIP ubiquitin ligase i...
Hierarchical sensory processing in zebrafish thalamocortical-like circuits
Thalamocortical projections shape the functional regionalization and parallel sensory computations across the mammalian cortex. However, the principles of thalamocortical computations in non-mammalian...
Manipulation of protein translation and stem cell self-renewal by CRISPR activation of rRNA transcription
Ribosomal RNA (rRNA) transcription rates vary during development, and their dysregulation is linked to diseases such as cancer and ribosomopathies. Owing to their high abundance and genomic redundancy...
A CDK1 phospho-switch reprograms TRAIP to unload replisomes in mitosis
Cells entering mitosis with incompletely replicated DNA face catastrophic chromosome segregation failure. During interphase, the replisome-associated E3 ubiquitin ligase TRAIP ubiquitylates barriers i...
A native sulfur deposit in Gale crater, Mars
Martian rocks are known to contain sulfur-bearing species, including sulfates and sulfides. These compounds record a sulfur cycle that operated over Mars’ geological evolution. We used the Curiosity r...