Science
Articles in this Issue
A Hormone Cell Atlas maps the human endocrine system at cellular resolution
Hormones act across tissues and organs to coordinate physiological functions. Drawing inspiration from the Human Cell Atlas, we analyzed the expression of 379 hormone and receptor genes in a transcrip...
Fruit flies actively restart their circadian clock by proactively shaping their environment
Circadian clocks provide adaptive advantages, enabling organisms to adjust their physiology and behavior to daily environmental changes on Earth. Here, we show that fruit flies prefer a temporally org...
Lab creates new kind of synthetic cell
“SpudCells” can grow and divide but still have major limitations
Patterning human kidney organoids with synthetic Wnt-secreting organizers
Human stem cell–derived miniature organs, including kidney organoids, reproduce aspects of tissue development but lack reliable spatial patterning. In embryos, spatial organization is often establishe...
Retraction
Height does not impair the hydraulic system of the tallest tropical Dipterocarp trees
Half of the aboveground biomass in forests is stored in a disproportionately small number of very tall trees. These giants are predicted to be more vulnerable to drought-induced damage because height...
A classroom contract for AI
WWII and the evolution of US federal research funding
Many fundamental innovation policies were developed during World War II that persist in some form to this day
A dietary switch promotes sensory neuron–dependent cancer-associated cachexia
Sickness behaviors are common in cancer-associated cachexia and affect up to half of lung cancer patients. We demonstrate that among the most common cancer mutations, loss of liver kinase B1 (...
Stop the biodiversity sampling arms race
Why have a revered physicist’s papers been retracted?
Springer Nature has removed two studies by quantum mechanics pioneer Max Planck. A bot may be to blame
Observation of disorder-free localization using a (2+1)D lattice gauge theory on a quantum processor
Disorder-induced phenomena in quantum many-body systems pose a challenge for analytical and numerical approaches at relevant time and system scales. To reduce the cost of disorder sampling, we investi...
Institutionalizing AI diplomacy in Africa
Ecology of the gut microbiome
Microbial competition can be harnessed to prevent and cure deadly diseases
Membrane protein solubilization and structure determination using de novo–designed proteins
Developing therapies and vaccines against integral membrane proteins is hindered by their extensive hydrophobic surfaces, which complicate production and structural analysis. Here, we describe a gener...
Making time
Flies seek out darkness to restart their biological clocks
The missing thriftiness
Host-microbial coevolution and its influence on human health