Science

Scalable fabrication of COF membranes for aliphatic/aromatic separation of crude oil

Distillation has been the cornerstone of crude oil refining for more than a century, relying on boiling point differences for fractionation. Although effective, it is highly energy-intensive and lacks...

Induction of broadly neutralizing HIV antibodies by a two-step mechanism informs vaccine design

A major obstacle confronting HIV-1 vaccine and cure research is the lack of an outbred animal model for rapid and consistent induction of broadly neutralizing antibodies (bNAbs). We designed an epitop...

El Niño is here. It may be the strongest this century

After clearing a spring forecasting hurdle, scientists see growing odds of a powerful climate event that could disrupt weather worldwide

Inheriting trauma, rethinking science

Violet seed propulsion inspires robot design

Comparative analysis of seed biomechanics reveals principles that can guide soft robot technology

Big Ebola outbreak puts research spotlight on little-known virus

The Bundibugyo virus only emerged twice before. Now, scientists see a chance to get to know it better

Protein-templated synthesis of dinucleotide repeat DNA by an antiphage reverse transcriptase

Defense-associated reverse transcriptases (DRTs) are widespread bacterial antiphage systems that use unconventional mechanisms of polynucleotide synthesis. We show that DRT3, which comprises two disti...

Direct development of stem tetrapods across the fin-to-limb transition

Modern amphibians are characterized by an aquatic larval stage that ends abruptly with a period of widespread tissue remodeling (metamorphosis) upon transition to terrestrial adulthood. A transient la...

Hour of the wolf

Wolves have made a spectacular comeback in Europe. But attacks on livestock and humans have caused a heated debate about the limits of coexistence

ScS-triggered slip on megathrust interfaces after the 2011 <i>M</i> _W 9.0 Tohoku-Oki earthquake

We report an extraordinary observation of ground motion in Japan after the moment magnitude ( M W ) 9.0 2011 Tohoku-Oki earthquake attribute...

Decoupling of global metabolic flux and proteome partitioning in bacteria

Bacteria regulate homeostatic growth by adjusting proteome composition. In Escherichia coli , this coordination is mediated by guanosine tetraphosphate and pent...

AI finds legal loopholes, even when not asked

Models repeatedly discovered ways to exploit regulations, and current safeguards largely failed to stop them

Lamprey 3D single-cell transcriptomics reveals ancestral and specialized features of the vertebrate brain

The lamprey occupies a pivotal position for elucidating vertebrate brain evolution. Using spatial transcriptomics and single-nucleus RNA sequencing, we generated a three-dimensional molecular atlas of...

Maternal trans-vaccenic acid shapes neonatal T cell development and early-life immune imprinting

How maternal nutrition influences neonatal immune development and imprinting through breastfeeding remains largely unclear. We report that maternal supplementation with trans-vaccenic acid (TVA), the...

Tracking the roots of zoonoses

Ancient pathogen DNA from animals elucidates the origin and evolution of infectious diseases

AI may raise the bar and thin the pipeline

Managing the pitfalls of private money

An HIV vaccine blueprint

The infection of rhesus macaques with a chimeric virus uncovers a recipe for broadly neutralizing antibodies

Scientific computing in an AI world

Scientific computing must integrate AI with simulation and focus on energy-efficient methods and systems

Preserve EEOC data collection

A metastable solid solution transforms into complex nanostructures

Instability in a high-entropy alloy drives structural changes that strengthen the alloy

Brain-wide topographic coordination of rotating waves

Patterns of brain activity moving in waves occur across brain regions and species, yet their spatial organization, anatomical basis, and brain-wide distribution remain unclear. Using cortex-wide imagi...

Unlikely chemistry of life may have originated on the ocean floor

Group offers new scenario for how cells came to rely on phosphate molecules

Paws for thought

The Lucy flyby of (52246) Donaldjohanson: A bilobed asteroid with tumbling rotation

The main belt asteroid (52246) Donaldjohanson (DJ) is a likely member of the Erigone asteroid family. This implies that DJ is a fragment of a larger parent body that was destroyed in a collision about...