PLoS ONE
Articles in this Issue
Screening of serum biomarkers in patients with PCOS through lipid omics and ensemble machine learning
Polycystic ovary syndrome (PCOS) is a primary endocrine disorder affecting premenopausal women involving metabolic dysregulation. We aimed to screen serum biomarkers in PCOS patients using untargeted...
Biomechanical effects of saddle height changes in leisure cycling with unilateral transtibial prostheses: A simulated study
Cycling is a beneficial physical activity for rehabilitating individuals with lower-limb amputations and serves as a feasible leisure sport. However, the optimal bicycle configuration for cycling with...
Supervised pulmonary tele-rehabilitation and individualized home-based pulmonary rehabilitation for patients with COPD, unable to participate in center-based programs. The protocol for a multicenter randomized controlled trial - the REPORT study
Introduction Chronic obstructive pulmonary disease (COPD) costs EURO 1.4 billion annually in healthcare costs. Pulmonary rehabilitation (PR) is a vital aspect of care for patients with COPD, but despi...
Practices and preferences in the use of magnification among endodontists and restorative dentists: A multicentre study
Background and objectives Aim of the current study was to assess the perception, preference, and practice of endodontists and restorative dentists at different locations around the world about dental...
Research protocol for a systematic review and meta-analysis of the effects of music on anxiety and physiological outcomes in patients undergoing bronchoscopy
Introduction Bronchoscopy is a routine clinical examination that can cause discomfort and anxiety in patients. This paper presents a protocol for a systematic review and meta-analysis aiming to assess...
Novel deep neural network architecture fusion to simultaneously predict short-term and long-term energy consumption
Energy is integral to the socio-economic development of every country. This development leads to a rapid increase in the demand for energy consumption. However, due to the constraints and costs associ...
An interpretable machine learning model for predicting in-hospital mortality in ICU patients with ventilator-associated pneumonia
Background Ventilator-associated pneumonia (VAP) is a common nosocomial infection in ICU, significantly associated with poor outcomes. However, there is currently a lack of reliable and interpretable...
Perceptions of access to harm reduction services during the COVID-19 pandemic among people who inject drugs in metropolitan Chicago
Background The COVID-19 pandemic amplified the risk environment for people who inject drugs (PWID), making continued access to harm reduction services imperative. Research has shown that some harm red...
Barriers and enablers to opioid deprescription: A qualitative study
Background Canada has the fourth highest per capita rate of opioid prescriptions in the world, contributing to the country’s opioid crisis. Due to both their pain-relieving and euphoric properties, op...
APOE4 and infectious diseases jointly contribute to brain glucose hypometabolism, a biomarker of Alzheimer’s pathology: New findings from the ADNI
Background Impaired brain glucose metabolism is a preclinical feature of neurodegenerative diseases such as Alzheimer’s disease (AD). Infections may promote AD-related pathology. Therefore, we investi...
Deep learning-based differential gut flora for prediction of Parkinson’s
Background There had been extensive research on the role of the gut microbiota in human health and disease. Increasing evidence suggested that the gut-brain axis played a crucial role in Parkinson’s d...
Effects of pre-oxidation temperature and air volume on oxidation thermogravimetric and functional group change of lignite
To investigate the impact of the oxidation temperature and variations in airflow conditions on coal spontaneous combustion characteristics, pre-oxidized coal samples were prepared using a programmed t...
The role of mitochondrial dysfunction in the cytotoxic synergistic effect of gemcitabine and arsenic on breast cancer
Breast cancer is the most common type of cancer in women worldwide. A common approach to cancer treatment in clinical practice is to use a combination of drugs to enhance the anticancer activity of dr...
Factors associated with the delay in diagnosis of extrapulmonary tuberculosis at the patient and health system level: A study from a rural setting in India
Background With the proportion of tuberculosis cases that are extrapulmonary tuberculosis (EPTB) increasing in recent years, understanding and addressing factors contributing to the prolonged time to...
Solar radiation model and optimization of asymmetric large-span externally insulated plastic greenhouses
To improve the light environment of asymmetric large-span externally insulated plastic greenhouses, a solar radiation model that considers the projection path equations of the insulation quilts and va...
The ambiguous role of partially protected marine protected areas in Australia: Results from a systematic literature review
Marine protected areas (MPAs) are an important tool in helping to protect biodiversity in the oceans. Recent ratification of the Kunming-Montreal Global Biodiversity Framework (GBF) has ensured that g...
Optimization design and application of library face recognition access control system based on improved PCA
The application of face recognition technology in Library Access Control System (LACS) has an important impact on improving the security and management efficiency of the library. However, the traditio...
Survival machine learning methods for mortality prediction after heart transplantation in the contemporary era
Although prediction models for heart transplantation outcomes have been developed previously, a comprehensive benchmarking of survival machine learning methods for mortality prognosis in the most cont...
Integrative metabolomics and transcriptomics profiling reveals differential expression of flavonoid synthesis in Ophiopogon japonicus (L. f.) Ker-Gawl. in adaptation to drought
Drought is one of the consequences of climate change that severely affects plant growth and development. Ophiopogon japonicus (L. f.) Ker-Gawl. (Chinese name: Chuanmaidong, abbreviated as CMD) is a co...
Innovameter: Agent-based modeling of innovation determinants in American and European countries
This article discusses the dynamics of innovation in America and Europe, focusing on variables such as access to technology, education, and life expectancy. To do this, the article proposes an agent-b...
Changing patterns of general practice services during a period of public sector investment in Britain
Introduction Given the importance of GP care to the public’s health, it is important that we understand how patterns of service use change as levels of investment change. This study investigated GP us...
Association between serum uric acid, hyperuricemia and low muscle mass in middle-aged and elderly adults: A national health and nutrition examination study
Backgrounds Recent research suggests that uric acid, as a metabolite with antioxidant properties, may affect muscle function and health. However, the association between serum uric acid (SUA) and low...
Child welfare worker perspectives on documentation and case recording practices in Canada: A mixed-methods study protocol
In health care and child welfare, clinical records and case notes serve multiple functions. When records are aggregated and processed to create administrative data, they can be analyzed and used to in...
Is executive attention affected by environmental lighting conditions?
Bright daylight has various positive influences, such as the long-term synchronization of circadian rhythms and an associated alertness that creates optimal conditions for attentional performance. How...
Chlorogenic acid inhibits NLRP3 inflammasome activation through Nrf2 activation in diabetic nephropathy
Diabetic nephropathy (DN) is the single largest cause of end-stage renal disease (ESRD). Inflammation reaction mediated by NLRP3 inflammasome and Nrf2-related oxidative stress have been considered to...