PLoS ONE
Articles in this Issue
Paternal family history of premature atherosclerotic disease and perinatal death: A population-based cohort study
Background Studies have reported that pregnancies conceived by fathers with modifiable cardiovascular risk factors are at higher risk of ending in losses compared to those without such risk factors. O...
Shared governance increases marine protected area effectiveness
Marine protected areas (MPAs) are widely used to conserve and manage coastal resources. Protected areas are governed by a variety of institutional arrangements, yet little is known concerning the rela...
Characterizing the services provided by family physicians in Ontario, Canada: A retrospective study using administrative billing data
Family physicians in Ontario provide most of the primary care to the healthcare system. However, given their broad scope of practice, they often provide additional services including emergency medicin...
In vitro and in vivo evaluation of Ulva lactuca for wound healing
Ulva lactuca (U. lactuca) is an important seaweed species. Some ingredients in this species are thought to accelerate wound healing. However, limited data on the use of seaweed for wound healing exist...
Depression among people living in rural and urban areas of Thailand: A cross-sectional study
Background Depression has a growing trend in the population worldwide. In this cross-sectional study, we investigated the prevalence and associated factors of depression among individuals residing in...
Mesothelial cell responses to acute appendicitis or small bowel obstruction reactive ascites: Insights into immunoregulation of abdominal adhesion
Previous abdominal surgery (PAS) increases risk of small bowel obstruction (SBO) due to adhesions, and appendectomy (appy) is an independent risk factor for abdominal adhesion-related complications. P...
Global, regional, and national survey on burden and Quality of Care Index (QCI) of orofacial clefts: Global burden of disease systematic analysis 1990–2019
Background Orofacial clefts are the most common craniofacial anomalies that include a variety of conditions affecting the lips and oral cavity. They remain a significant global pub...
Five year mortality in an RCT of a lung cancer biomarker to select people for low dose CT screening
The role of biomarkers in risk-based early detection of lung cancer may enable screening to become cost effective and widely accessible. EarlyCDT-Lung is an example of such a blood-based autoantibody...
An implementation trial to mAnage siCkle CELl disEase through incReased AdopTion of hydroxyurEa in Nigeria (ACCELERATE): Study protocol
Background Despite the proven efficacy of evidence-based healthcare interventions in reducing adverse outcomes and mortality associated with Sickle Cell Disease (SCD), a vast majority of affected indi...
SPEED (SPlEnic Embolisation Decisions) study—Decision to treat acute traumatic splenic artery injury in the context of trauma protocol
Background The spleen is commonly injured in trauma and this may be managed with a conservative approach, embolisation or splenectomy. There is uncertainty how splenic embolisation fits into the treat...
Views and opinions of the general public about the reimbursement of expensive medicines in the Netherlands
Objectives Solidarity-based healthcare systems are being challenged by the incremental costs of new and expensive medicines for cancer and rare diseases. To regulate reimbursement of such drugs, the D...
Men’s gender role and attitude toward sexual autonomy of women in India
Objective Sexual autonomy is essential to women’s empowerment and crucial to human rights. Measurement of women’s sexual autonomy from men’s perspective is rare in India, though critical for achieving...
Optimization of the green synthesis of gold nanorods using aqueous extract of peeled sour guava as a source of antioxidants
Obtaining gold nanorods (AuNRs) through biosynthesis is an alternative that replaces the traditional use of ascorbic acid with chemical compounds such as polyphenols, owing to their notable antioxidan...
Evaluation of keratometric and total corneal astigmatism measurements from optical biometers and anterior segment tomographers and mapping to reconstructed corneal astigmatism vector components
Purpose To investigate different measures for corneal astigmatism in the context of reconstructed corneal astigmatism (recCP) as required to correct the pseudophakic eye, and to derive prediction mode...
Factors associated with chronic kidney disease knowledge and preventive practices: An analytical cross-sectional study among patients with hypertension at Amana Regional Referral Hospital in Dar es Salaam, Tanzania
Background Globally, Chronic kidney Disease (CKD) has become a significant public health concern, with sub-Saharan Africa being among the populations experiencing the highest rates. Managing CKD poses...
Applying fractional calculus to malware spread: A fractal-based approach to threat analysis
Malware is a common word in modern era. Everyone using computer is aware of it. Some users have to face the problem known as Cyber crimes. Nobody can survive without use of modern technologies based o...
Does a priming warm-up influence the incidence of V˙O2pl during a ramp test and verification phase?
Objective This study compared the effects of two different warm-up protocols (normal vs. priming) on the oxygen plateau (V˙O2pl) incidence rate during a ramp test. It also compared the cardiopulmonary...
Anti-nucleocapsid SARS-CoV-2 antibody seroprevalence in previously infected persons with immunocompromising conditions—United States, 2020–2022
People with immunocompromising conditions (IC) are at increased risk of severe COVID-19 and death. These individuals show weaker immunogenicity following vaccination than individuals without IC, yet i...
Comparative evaluation of high-flow nasal cannula (HFNC) and conventional oxygen therapy (COT) in infants after non-cardiac surgery: Study protocol of a randomized controlled trial
Background Literature regarding the advantages of HFNC in infants for ensuring oxygen supply after non-cardiac surgery is insufficient. The purpose of our study is to compare COT vs. HFNC on postopera...
A retrospective single-center pilot study of the genetic background of the transplanted kidney
Introduction Renal cell carcinoma (RCC) is one of the most prevalent cancers in kidney transplant recipients (KTR). The hereditary background of RCC in native kidneys has been determined, implicating...
Decreased risk-proneness with increasing age in equally raised and kept wolves and dogs
A basic mechanism of domestication is the selection for fearlessness and acceptance of humans as social partners, which may affect risk-taking behavior and the ability to use humans as social support,...
Bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) in treatment-naïve and treatment-experienced people with HIV: 12-month virologic effectiveness and safety outcomes in the BICSTaR Japan cohort
BICSTaR (BICtegravir Single Tablet Regimen) is an ongoing, observational cohort study assessing the virologic effectiveness and safety of bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) in t...
Burden of chronic obstructive pulmonary disease in adults aged 70 years and older, 1990–2021: Findings from the Global Burden of Disease Study 2021
Background Life expectancy at age 70 has continued to rise globally over the past 30 years. However, a comprehensive assessment of the burden of COPD in older adults is lacking. We aimed to estimate t...
Spatial variation and determinant factors of alcohol consumption in Ethiopia: Spatial and multilevel analysis of Ethiopian demographic and health survey
Background Alcohol consumption continues to be a public health problem in Ethiopia. Previous investigations have been conducted on alcohol consumption in Ethiopia; however, these investigations were l...
Schizophrenia more employable than depression? Language-based artificial intelligence model ratings for employability of psychiatric diagnoses and somatic and healthy controls
Artificial Intelligence (AI) assists recruiting and job searching. Such systems can be biased against certain characteristics. This results in potential misrepresentations and consequent inequalities...