PLoS ONE
Articles in this Issue
LFA-1: A potential key player in microglia-mediated neuroprotection against oxygen-glucose deprivation in vitro
For the last 38 years, all neuroprotective agents for patients with ischemic stroke have failed in clinical trials. The innate immune system, particularly microglia, is a much-discussed target for neu...
Exploring early Acheulian technological decision-making: A controlled experimental approach to raw material selection for percussive artifacts in Melka Wakena, Ethiopia
The evolution of human behaviour is marked by key decision-making processes reflected in technological variability in the early archaeological record. As part of the technological system, differences...
Determination of production capacity for open-pit coal mines under uncertainty: A model based on economies of scale
The determination of optimal production capacity for open-pit mines is influenced by various economic and technical factors and is highly susceptible to uncertainties. To effectively address the impac...
Topographic changes in macula and its association with visual outcomes in idiopathic epiretinal membrane surgery
Purpose We investigated changes in macular topography and their association with visual acuity and metamorphopsia in the idiopathic epiretinal membrane (iERM). Methods Twenty-four eyes that underwen...
Intraoperative transcutaneous electrical acupoint stimulation combined with anesthesia to prevent postoperative cognitive dysfunction: A systematic review and meta-analysis
Background Postoperative cognitive dysfunction (POCD) is associated with an increased risk of dementia and may lead to chronic neurodegeneration. The utilization of intraoperative Transcutaneous Elect...
A novel framework for increasing research transparency: Exploring the connection between diversity and innovation
A split sample/dual method research protocol is demonstrated to increase transparency while reducing the probability of false discovery. We apply the protocol to examine whether diversity in ownership...
Increased consumption of ultra-processed foods and worse diet quality in colorectal cancer patients after colostomy: A prospective study
Colorectal cancer (CRC) is commonly treated with intestinal resections that lead to colostomy, which can influence changes in eating habits. This study aimed to analyze energy and nutrient intake, die...
The gut microbiota-SCFA-inflammation axis in patients with AECOPD
Objectives The aim of the study was to explore the alteration of microbiota and SCFA in gut and inflammation in acute exacerbation chronic obstructive pulmonary disease (AECOPD) patients, and to test...
Effect of individual variations in genes related to dopamine brain transmission on performance with and without rewards during motor sequence and probabilistic learning tasks in children and young adults with and without cerebral palsy
Children with cerebral palsy (CP) often participate in training to improve mobility, hand function and other motor abilities. However, responses to these interventions vary considerably across individ...
Establishment of a physical exercise evaluation index system for school-age children with asthma
Objective To construct a comprehensive physical exercise evaluation index system for asthmatic children aged 6–12 years. Design Based on knowledge-attitude-practice(KAP) theory, we constructed an it...
Validation of polymorphic Gompertzian model of cancer through in vitro and in vivo data
Mathematical modeling plays an important role in our understanding and targeting therapy resistance mechanisms in cancer. The polymorphic Gompertzian model, analyzed theoretically and numerically by V...
Study on the relationship between microbial composition within obstructive biliary stents and the severity of obstruction and duration of stent placement
Biliary stent occlusion is due, in part, to biofilm formation by bacteria. However, previous culture-based approaches may not have revealed all microorganisms on the surface. Twenty-seven patients und...
A genomics learning framework for undergraduates
Genomics is an increasingly important part of biology research. However, educating undergraduates in genomics is not yet a standard part of life sciences curricula. We believe this is, in part, due to...
Genetic insights into the risk of hip osteoarthritis on stroke: A single-variable and multivariable Mendelian randomization
Background Hip osteoarthritis has been identified as a potential risk factor for stroke, with previous studies have demonstrated an association between hip osteoarthritis and stroke. This study aims t...
Divergent Cotton leaf curl Multan betasatellite and three different alphasatellite species associated with cotton leaf curl disease outbreak in Northwest India
Cotton leaf curl disease (CLCuD) is a major constraint for production of cotton (Gossypium sp.) in Northwest India. CLCuD is caused by a monopartite, circular ssDNA virus belonging to the genus Begomo...
Interrogating green social prescribing in South Wales; A multi-stakeholder qualitative exploration
Background As an umbrella term, social prescribing offers varied routes into society which promise to support, enhance, and empower individual citizens to take control of their own health and wellbein...
Patient safety indicators for virtual consultations in primary care: A systematic review protocol
Background Virtual consultations are being increasingly incorporated into routine primary care, as they offer better time and geographical flexibility for patients while also being cost-effective for...
From union clout to corporate couture: Unveiling the impact of trade unions on corporate social responsibility
Trade unions and corporate social responsibility (CSR) are important institutional mechanisms through which corporations undertake responsibility for their for-profit as well as not-for-profit actions...
Diaper dermatitis and associated factors among children aged 0–24 months in low- and middle-income countries: A systematic review protocol
Background Diaper dermatitis (DD, sometimes known as diaper rash or napkin dermatitis is one of the most prevalent skin infections that occur in the area covered by the diaper. Although diaper dermati...
A META analysis and systematic review of the effects of exercise interventions on middle-aged and elderly patients with depression
Objective This study sought to conduct a meticulous systematic review, delving into the efficacy of exercise interventions on depressive symptoms among middle-aged and older adults. Additionally, we a...
Hemoglobin, albumin, lymphocyte and platelet (HALP) score for predicting early and late mortality in elderly patients with proximal femur fractures
Background Predicting mortality and morbidity poses a significant challenge to physicians, leading to the development of various scoring systems. Among these, the hemoglobin, albumin, lymphocyte and p...
Prevention of unplanned extubation in neonatal patients: Protocol for a systematic review and meta-analysis
Unplanned extubation (UPE), defined as accidental removal of the endotracheal tube during mechanical ventilation or its replacement due to suspected obstruction or inadequate diameter, is considered t...
Preliminary experience and learning curve of endoscopic nipple-areolar-complex sparing total mastectomy: A single-center retrospective study
Background In this study, the preliminary experience of endoscopic nipple-areolar-complex (NAC) sparing total mastectomy were analyzed and reported. Methods The medical records of the patients who u...
Azithromycin removal from water via adsorption on drinking water sludge-derived materials: Kinetics and isotherms studies
In this study, we utilized drinking water treatment sludge (WTS) to produce adsorbents through the drying and calcination process. These adsorbents were then evaluated for their ability to remove azit...
Design and evaluation of a problem-based learning VR module for apparel fit correction training
The increased adoption of three-dimensional (3D) digital prototyping software programs makes it necessary to train novice designers to use these programs efficiently. However, existing studies spannin...