PLoS ONE
Articles in this Issue
MicroRNA-221 protects myocardial contractility in myocardial ischemia/reperfusion injury through phospholamban
Objective To investigate the effects and mechanisms of miRNA 221 on myocardial ischemia/reperfusion injury (MIRI) in mice through the regulation of phospholamban (PLB) expression. Methods The MIRI m...
A novel classification method for balance differences in elite versus expert athletes based on composite multiscale complexity index and ranking forests
Balance is crucial for various athletic tasks, and accurately assessing balance ability among elite athletes using simple and accessible measurement methods is a significant challenge in sports scienc...
Breast and cervical cancer screening among women at reproductive age in Cambodia: A secondary analysis of Cambodia Demographic and Health Survey 2022
Breast and cervical cancers are the most prevalent diagnosed in women worldwide, significantly contributing to maternal morbidity and mortality. We examined socio-demographic and behavioral factors as...
Effect of cytotoxic CD8+ T-cells secretory proteins on hypoxic pancreatic cancer cells
Background Hypoxia in tumor cells is linked to increased drug resistance and more aggressive behavior. In pancreatic cancer, the tumor microenvironment is notably hypoxic and exhibits strong immunosup...
Possible influence of sex on the relationship between dual-task gait costs and cognitive decline in older adults
The impact of cognitive decline in older adults can be evaluated with dual-task gait (DTG) testing in which a cognitive task is performed during walking, leading to increased costs of gait. Previous r...
An untargeted metabolomic analysis of acute AFB1 treatment in liver, breast, and lung cells
Aflatoxin B1 (AFB1) is a class 1 carcinogen and mycotoxin known to contribute to the development of hepatocellular carcinoma (HCC), growth impairment, altered immune system modulation, and malnutritio...
Correction: Active versus sham transcranial direct current stimulation (tDCS) as an adjunct to varenicline treatment for smoking cessation: Study protocol for a double-blind single dummy randomized controlled trial
Stochastic simulation of soil moisture dynamics in farmland in the eastern region of the Songnen Plain
Soil moisture is the core of the hydrological cycle in agroecosystems, and most of the studies on soil moisture dynamics modeling adopt deterministic research methods, which are not well suited to stu...
Habitat suitability mapping and landscape connectivity analysis to predict African swine fever spread in wild boar populations: A focus on Northern Italy
African swine fever (ASF) is a highly contagious disease affecting wild and domestic pigs, characterised by severe haemorrhagic symptoms and high mortality rates. Originally confined to Sub-Saharan Af...
Genetic influence on choroidal vascularity index
Purpose To investigate the heritability of genetic influence on macular choroidal vascularity index (CVI). Methods Total choroidal area (TCA), luminal area (LA), and CVI was measured using horizonta...
Correction: Attributable risk factors for asymptomatic malaria and anaemia and their association with cognitive and psychomotor functions in schoolchildren of north-eastern Tanzania
Relationship between secondary metabolites and ecological suitability zones for Eucommia ulmoides
The quality of Chinese medicinal materials is closely related to the types and contents of their secondary metabolites, while ecological adaptability influences the production of secondary metabolites...
Investigating the miRNA-mRNA interactome of human trabecular meshwork cells treated with TGF-β1 provides insights into the pathogenesis of pseudoexfoliation glaucoma
Pseudoexfoliation glaucoma is a severe form of secondary open angle glaucoma and is associated with activation of the TGF-β pathway by TGF-β1. MicroRNAs (miRNAs) are small non-coding RNA species that...
Hearing in categories and speech perception at the “cocktail party”
We aimed to test whether hearing speech in phonetic categories (as opposed to a continuous/gradient fashion) affords benefits to “cocktail party” speech perception. We measured speech perception perfo...
Prevalence and genetic diversity of tick-borne encephalitis virus in ixodid ticks from specific regions of northwestern Russia
Russia is a country with a high incidence of tick-borne encephalitis (TBE). In northwestern regions of Russia, 110 TBE cases were registered in 2021. The largest numbers of TBE cases were registered i...
Evolution of the Danube River’s islands on the Bulgaria-Romania border over the last century
The border line between Bulgaria and Romania was established a century ago on the Danube River’s thalweg, going around islands. Over time, islands migrated; to avoid conflicts, islands located on the...
Enablers and barriers to community pharmacists’ readiness to implement deprescribing of inappropriate medications for older adults in Qatar
There is paucity of studies focused on the enablers and barriers to community pharmacists’ readiness to deprescribe inappropriate medications for older adults in developing settings. The current study...
Computational analysis of the effect of a binding protein (RbpA) on the dynamics of Mycobacterium tuberculosis RNA polymerase assembly
Background RNA polymerase-binding protein A (RbpA) is an actinomycetes-specific protein crucial for the growth and survival of the pathogen Mycobacterium tuberculosis. Its role is essential and influe...
An efficient interpretable framework for unsupervised low, very low and extreme birth weight detection
Detecting low birth weight is crucial for early identification of at-risk pregnancies which are associated with significant neonatal and maternal morbidity and mortality risks. This study presents an...
The effect of empathy on remote social connections via paired robots
A range of devices and technologies are available to mediate social connections between geographically distant people. Some of these methods exploit awareness information to enhance the connectedness...
Comprehensive analysis of ceRNA Networks in UCEC: Prognostic and therapeutic implications
Endometrial cancer (UCEC) is the most prevalent gynecological malignancy in high-income countries, and its incidence is rising globally. Although early-stage UCEC can be treated with surgery, advanced...
Correction: Price tag of glaucoma care is minor compared with the total direct and indirect costs of glaucoma: Results from nationwide survey and register data
Prognostic value of immune biomarkers in melanoma loco-regional metastases
The prognosis for patients with melanoma loco-regional metastases is very heterogenous. Adjuvant PD-L1-inhibitors have improved clinical outcome for this patient group, but the prognostic impact of tu...
Estimating the trend of COVID-19 in Norway by combining multiple surveillance indicators
Estimating the trend of new infections was crucial for monitoring risk and for evaluating strategies and interventions during the COVID-19 pandemic. The pandemic revealed the utility of new data sourc...