PLoS ONE
Articles in this Issue
White matter lesions and DTI metrics related to various types of dysfunction in cerebral palsy: A meta-analysis and systematic review
Background Assessing various types of dysfunction in cerebral palsy is a key factor in the treatment and rehabilitation of patients. The objective of this study was to use meta-analysis and systematic...
Optimization of cold chain logistics distribution path considering traffic condition and replenishment along the way
Road traffic congestion on the cold chain logistics not only increase the cost and time, but also creates certain negative impact on the national carbon emissions. To fully utilize the traffic resourc...
mGBP2 engages Galectin-9 for immunity against Toxoplasma gondii
Guanylate binding proteins (GBPs) are large interferon-inducible GTPases, executing essential host defense activities against Toxoplasma gondii, an invasive intracellular apicomplexan protozoan parasi...
Notch dimerization provides robustness against environmental insults and is required for vascular integrity
The Notch intracellular domain (NICD) regulates gene expression during development and homeostasis in a transcription factor complex that binds DNA either as monomer, or cooperatively as dimers. Mice...
Machine learning model to predict the adherence of tuberculosis patients experiencing increased levels of liver enzymes in Indonesia
Indonesia is still the second-highest tuberculosis burden country in the world. The antituberculosis adverse drug reaction and adherence may influence the success of treatment. The objective of this s...
Respiratory extracellular vesicle isolation optimization through proteomic profiling of equine samples and identification of candidates for cell-of-origin studies
Growing evidence supports the importance of extracellular vesicle (EV) as mediators of communication in pathological processes, including those underlying respiratory disease. However, establishing me...
What sustain Chinese adult second language (L2) learners’ engagement in online classes? A sequential mix-methods study on the roles of L2 motivation and enjoyment
Recent research has integrated positive psychology with the Second Language Motivational Self System (L2MMS) to explore how enjoyment, L2 self-guides (including ideal L2 self and ought-to L2 self), an...
Physical demands and physiological response of soccer referees in high-level matches: A systematic review
Background The match physical demands placed on soccer referees are intrinsically connected to their capacity to make accurate judgments, becoming the second most studied theme in associate soccer ref...
Healthcare resource utilization and costs in immunodeficient patients receiving subcutaneous Ig: Real-world evidence from France
Background Subcutaneous immunoglobulin (SCIg) replacement therapy is indicated for patients with hypogammaglobulinemia caused by primary (PID) and secondary immunodeficiencies (SID). Objective To co...
Realist evaluation of the AKU-SONAM mentorship program
Background & objectives The context, mechanism, and outcome (CMO) framework is meant to identify specific contextual factors (C) related to organizational and program structure that trigger certai...
Comparative readability of information on different treatment options for breast cancer, based on WeChat public accounts
Objective To evaluate and compare the readability of information on different treatment options for breast cancer from WeChat public accounts, propose targeted improvement strategies based on the eval...
Weight trajectories in aging humanized APOE mice with translational validity to human Alzheimer’s risk population: A retrospective analysis
Translational validity of mouse models of Alzheimer’s disease (AD) is variable. Because change in weight is a well-documented precursor of AD, we investigated whether diversity of human AD risk weight...
Correction: The Video Manipulation Effect (VME): A quantification of the possible impact that the ordering of YouTube videos might have on opinions and voting preferences
Association of chronic kidney disease with acute clinical outcomes and hospitalization costs of cancer resection
Purpose Patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) have been noted to face increased cancer incidence. Yet, the impact of concomitant renal dysfunction on acute outc...
Analysis of the effect of joint roughness on the failure mechanism of jointed rock mass under direct shear loading
The mechanical properties of jointed rock bodies are important in guiding engineering design and construction. Using the particle flow software PFC2D, we conducted direct shear test simulations on joi...
Factors influencing the adoption of e-government by female university students
The primary purpose of electronic government (e-government) is to promote transparency, facilitate access to government services, and strengthen the accountability of public institutions in the digita...
Exploring entrepreneurial intention among European Union youth by education and employment status
The relatively high vulnerability of young Europeans in the labour market compared to other age groups has led many to seek alternative employment solutions, such as entrepreneurship. While not a comp...
Assessing a bundle of peer counseling, mobile phone messages, and mama kits in promoting timely initiation of and exclusive breastfeeding in Uganda: A cluster randomized controlled study
Background Timely initiation of and exclusive breastfeeding have been recommended as key interventions to enable countries to attain the sustainable development target of reducing neonatal mortality t...
Assessment of the bypass of obturation materials beyond fractured instruments after using different obturation techniques in simulated curved canals (An in-vitro study)
This study evaluated the extent to which obturation materials bypass fractured endodontic instruments positioned in the middle and apical thirds of severely curved simulated root canals using differen...
Evaluating the performance of a new ergonomic laparoscopic needle holder for intracorporeal suturing
In laparoscopy, the absence of ergonomics in the instruments affects the performance and efficiency of the surgeon, increasing the likelihood of developing musculoskeletal injuries. This article prese...
The etiology of attention deficit disorder with hyperactivity: A protocol for an umbrella review
Introduction Attention deficit hyperactivity disorder (ADHD) is one of the common neurodevelopmental disorders and is widely prevalent worldwide. The primary symptoms of ADHD include inattention, impu...
Systematic review on the compliance of WHO guidelines in the management of patients with advanced HIV disease in Africa: The case of cryptococcal antigen screening
Background The World Health Organization (WHO) recommended cryptococcal antigen (CrAg) screening for people presenting with advanced HIV disease (AHD) and for those with positive CrAg without evidence...
Study protocol for a hybrid implementation-effectiveness trial of Game Changers for Cervical Cancer Prevention in Uganda
Introduction Cervical cancer (CC) is the leading cause of cancer-related deaths among Uganda women, yet rates of CC screening are very low. Training women who have recently screened to engage in advoc...
Secondary metabolites of Alternaria alternate appraisal of their SARS-CoV-2 inhibitory and anti-inflammatory potentials
This study identifies the secondary metabolites from Alternaria alternate and evaluates their ACE-2: Spike RBD (SARS-CoV-2) inhibitory activity confirmed via immunoblotting in human lung microvascular...
Effects of plasma-activated water on germination and initial seedling growth of wheat
In this research, the effect of seed halopriming with plasma activated water (PAW) on wheat germination parameters have been studied. Response surface methodology was used to investigate the effect of...