PLoS ONE
Articles in this Issue
Correction: Global trade of South Korea in competitive products and their impact on regional dependence
Understanding emotional and health indicators underlying the burnout risk of healthcare workers
Burnout of healthcare workers is of increasing concern as workload pressures mount. Burnout is usually conceptualised as resulting from external pressures rather than internal resilience and although...
Efficacy of videoconferencing-delivered cognitive behavioural therapy to reduce anxiety disorder severity in LGBTQ+ people: An exploratory trial protocol
Objective Cognitive behavior therapy (CBT) is a well-established treatment for anxiety disorders in the general population. However, the efficacy of CBT for lesbian, gay, bisexual, transgender, queer,...
Preliminary screening of new biomarkers for sepsis using bioinformatics and experimental validation
Background The morbidity and mortality of sepsis remain high, and so far specific diagnostic and therapeutic means are lacking. Objective To screen novel biomarkers for sepsis. Methods Raw sepsis...
Assembly and application of a low-cost high-resolution imaging device for hyphae in soil
Soil imaging in the field and laboratory has greatly advanced our understanding of plant root systems. Soil fungi function as important plant symbionts and decomposers of complex organic material in s...
Correction: Association between cancer stigma and cervical cancer screening uptake among women of Dhulikhel and Banepa, Nepal
Evidence of a persistent altered neural state in people with fibromyalgia syndrome during functional MRI studies and its relationship with pain and anxiety
Altered neural signaling in fibromyalgia syndrome (FM) was investigated with functional magnetic resonance imaging (fMRI). We employed a novel fMRI network analysis method, Structural and Physiologica...
Weak acid and pepsin reflux induce laryngopharyngeal mucosal barrier injury: A rabbit-model-based study
Objective Using rabbit models, this study simulated the laryngopharynx’s response to the synergistic effects of various acidic reflux environments and pepsin to investigate the response mechanism unde...
Correction: High prevalence of p16 staining in malignant tumors
Expanded non-invasive prenatal testing offers better detection of fetal copy number variations but not chromosomal aneuploidies
Purpose To evaluate the clinical performance of expanded non-invasive prenatal testing (NIPT-plus) and compare its effectiveness in screening for chromosomal aneuploidies with that of NIPT. Methods...
Probiotics interventions modulating gut microbiota composition in individuals with intestinal constipation: Protocol of a systemic review and meta-analysis of randomized controlled trials
Introduction Intestinal constipation is a substantive global health concern, significantly impairing patient quality of life. An emerging view is that the gut microbiota plays a critical role in intes...
Insights into the representativeness of biodiversity assessment in large reservoir through eDNA metabarcoding
Monitoring biodiversity on a large scale, such as in hydropower reservoirs, poses scientific challenges. Conventional methods such as passive fishing gear are prone to various biases, while the utiliz...
Effects of Cinnamomum zeylanicum (Ceylon cinnamon) extract on lipid profile, glucose levels and its safety in adults: A randomized, double-blind, controlled trial
Background Cinnamon has been studied as a possible way to control blood glucose and serum cholesterol levels. However, there are no well-conducted randomized controlled trials that can accurately meas...
Nebulization of 2% lidocaine has no detectable impact on the healthy equine respiratory microbiota
Glucocorticosteroids remain the most common pharmaceutical approach for the treatment of equine asthma but can be associated with significant side effects, including respiratory microbiome alterations...
Measurement properties of instruments to assess insight in psychosis: A systematic review protocol
Introduction Insight in psychosis, defined as a patient’s awareness and judgment of their mental illness, is a complex and evolving concept. Historically, the absence of insight was considered a defin...
Low agreement and frequent invalid controls in two SARS-CoV-2 T-cell assays in people with compromised immune function
T-cell response plays an important role in SARS-CoV-2 immunogenicity. For people living with HIV (PWH) and solid organ transplant (SOT) recipients there is limited evidence on the reliability of comme...
Identification of hypertension gene expression biomarkers based on the DeepGCFS algorithm
Hypertension is a critical risk factor and cause of mortality in cardiovascular diseases, and it remains a global public health issue. Therefore, understanding its mechanisms is essential for treating...
The impact of a commercial lower extremity exoskeleton on metabolic load, perceived exertion, and physiological response to a challenging military relevant task: A randomized cross-over design pilot study
Purpose To assess physiological metrics during the use of a commercially available bilateral active ankle exoskeleton during a challenging military-relevant task and if use of the exoskeleton during t...
Influences of roughness and filling degree on the shear strength and damage evolution characteristics of cement-filled joints
The shear resistance of filling joints is an important factor affecting the stability of rock joints. Pressure-shear tests of cement-filled joints were carried out. Combined with the acoustic emission...
Usual prevention in unusual settings: A scoping review of place-based health interventions in public-facing businesses
Place-based health interventions may help reach underserved populations. This scoping review summarizes the peer-reviewed literature on the type and effects of place-based health interventions in unco...
Relationship between floating toe score and performance in track and field athletes
This study explored the relationship between floating toes and athletic performance among collegiate track and field athletes. A total of 422 athletes (sprinters, jumpers, and distance runners) and 13...
Structure-guided identification of mitogen-activated protein kinase-1 inhibitors towards anticancer therapeutics
Mitogen-activated protein kinase 1 (MAPK1) is a serine/threonine kinase that plays a crucial role in the MAP kinase signaling transduction pathway. This pathway plays a crucial role in various cellula...
Correction: Aqueous spice extracts as alternative antimycotics to control highly drug resistant extensive biofilm forming clinical isolates of Candida albicans
A pangenome analysis reveals the center of origin and evolutionary history of Phytophthora infestans and 1c clade species
We examined the evolutionary history of Phytophthora infestans and its close relatives in the 1c clade. We used whole genome sequence data from 69 isolates of Phytophthora species in the 1c clade and...
Efficacy and safety of creatine phosphate sodium in the treatment of viral myocarditis: A systematic review and meta-analysis
Purpose To systematically evaluate the efficacy and safety of creatine phosphate sodium in the treatment of viral myocarditis, and to provide guidance for its clinical treatment. Methods We conducte...