PLoS ONE
Articles in this Issue
UVESCREEN1: A randomised feasibility study of imaging-based uveitis screening for children with juvenile idiopathic arthritis- Study Protocol
Children with Juvenile Idiopathic Arthritis (JIA) are at a currently unpredictable risk of a blinding, often asymptomatic, co-existent eye disorder, anterior uveitis which requires prompt treatment. T...
Comparison of stable isotope mixing models for examining plant root water uptake
As natural isotope tracers, δ18O and δ2H have been widely applied to examine the water uptake of plant root, but the various stable isotope mixing models may lead to different explanations. To underst...
LncRNA UCA1 regulates immune micro-environment in cisplatin-induced AKI by miRNA-4498/AKT3 pathway
An increasing number of studies highlight the significance of long non-coding RNAs (lncRNAs) in the biological process of acute kidney injury (AKI). This study investigates the role and the mechanism...
Efficacy of early enteral nutrition support on the nutritional status of patients after gallstone surgery
Objective To evaluate the overall efficacy of early enteral nutrition support on the nutritional status of patients following gallstone surgery, providing a theoretical basis for its application in po...
Guanine crystal formation by the unicellular organism Phacotus lenticularis is part of a cellular stress response
Organic crystals, and in particular guanine crystals, are widely used by multicellular organisms for manipulating light and producing structural colors. Many single celled eukaryotic organisms also pr...
Distribution of ilmenite minerals in placer deposits along the middle coast of Southern Brazil using spaceborne and ground-based remote sensing
Titanium oxide is of fundamental strategic importance in the global market as it is used as a raw material by several industries, such as medical prostheses, paints, pigments, and, more recently, elec...
Correction: Correlation between postmortem microbial signatures and substance abuse disorders
Lasting lockdown love? Problem behaviour and pandemic and non-pandemic related risk factors influencing the owner-dog relationship in a UK cohort of dogs reaching early adulthood
The owner-dog relationship is a critical component of sustained dog ownership. Increased understanding of risk factors for weak owner-dog relationships can identify owner-dog dyads at higher risk of p...
Spatial and temporal distribution characteristics and influencing factors of cultural heritage: A case of the Grand Canal (East Zhejiang section)-maritime silk road
The Grand Canal and the Maritime Silk Road in China are globally significant cultural routes, which have contributed a wealth of cultural heritage through their historical development. The study on th...
Optimisation of the preparation phase for orthopaedic surgery: Study protocol for a student-led multimodal prehabilitation feasibility trial (BoneFit)
Background Since the Covid-19 pandemic, a surgical backlog for total hip replacement (THR) and total knee replacement (TKR) surgery remains in the United Kingdom. Multimodal prehabilitation pathways (...
Designing of a multiepitope-based vaccine against echinococcosis utilizing the potent Ag5 antigen: Immunoinformatics and simulation approaches
Echinococcosis is a significant parasitic zoonotic disease with severe implications for human and animal health. To date, there has been no effective vaccine candidate available for echinococcosis. Th...
Health-promoting text messages to patients with hypertension—A randomized controlled trial in Swedish primary healthcare
Due to the high prevalence and great cardiovascular risks of hypertension, we need effective and evidence-based treatment strategies. Health-promoting one-way text messages could be a beneficial compl...
The impact of rural revitalization talent cultivation on farm household part-time farming: Evidence from the “One Village, One University Student” program
The key to rural revitalization lies in talent revitalization. Cultivating a workforce that understands agriculture, loves rural areas, and cares for farmers, while retaining talent in rural regions,...
Accuracy of the Modified Finnish Diabetes Risk Score (Modified FINDRISC) for detecting metabolic syndrome: Findings from the Indonesian national health survey
Background This study evaluated the diagnostic accuracy of the Modified Finnish Diabetes Risk Score (Modified FINDRISC) for detecting individuals with metabolic syndrome in Indonesia. Methods A data...
Clinical status and cytokine profiles in patients with asthma or chronic obstructive pulmonary disease vaccinated against influenza
Background Influenza vaccine is a tool for preventing infection and reducing exacerbations in patients with asthma and chronic obstructive pulmonary disease (COPD). However, the associations between c...
Development of a reliable, sensitive, and convenient assay for the discovery of new eIF5A hypusination inhibitors
eIF5A is a translation factor dysregulated in several pathologies such as cancer and diabetes. eIF5A activity depends upon its hypusination, a unique post-translational modification catalyzed by two e...
Association between mixed venous oxygen saturation and serum uric acid levels in patients with heart failure
Hypoxia leads to increased purine metabolism in tissues, resulting in increased serum uric acid levels, and may also cause impaired uric acid excretion in the kidneys and intestinal tract. However, th...
Monkeys can identify pictures from words
Humans learn and incorporate cross-modal associations between auditory and visual objects (e.g., between a spoken word and a picture) into language. However, whether nonhuman primates can learn cross-...
HypE-GA based study on optimal design of standard floor facade windowing of high-rise office buildings facing energy saving in heating, cooling and lighting
The quantitative design on area and location of building façade’s windows has a significant impact on interior light and heat environment, which is also very instructive for preliminary and remodeling...
Factors associated with the use of dental services in older adults in Peru
Background The use of dental services by older adults in Peru faces various challenges that impact both their oral and overall health. Several factors play a crucial role in obtaining adequate dental...
Correction: Cover crops support the climate change mitigation potential of agroecosystems
Participant experiences receiving acupuncture for acute musculoskeletal pain in an emergency department: A qualitative evaluation
Objective Acupuncture is an evidence-based pain treatment in clinic settings, but its optimal delivery has not been established in emergency departments (EDs). As part of an adaptive pragmatic randomi...
Potential of methanol extracts of Nephelium lappaceum (Sapindaceae) and Hyphaene thebaica (Arecaceae) as adjuvants to enhance the efficacy of antibiotics against critical class priority bacteria
Botanicals have shown promise in mitigating antibiotic resistance in bacteria. This study examined the efficacy of methanolic extracts from two food plants (Nephelium lappaceum and Hyphaene thebaica),...
Layout optimization of multi-level cold chain storage facilities in agricultural producing areas considering type and capacity constraints
The effective circulation of fresh agricultural products is conducive to increasing farmers’ income and improving the living standards of urban residents. Cold chain storage facilities in agricultural...
Hyperspectral technology and machine learning models to estimate the fruit quality parameters of mango and strawberry crops
Using chemical laboratory procedures to estimate the fruit quality parameters (biochemical parameters) of mango "Succarri" and strawberry "Florida" as indicators of ripening degrees in a large area pr...