PLoS ONE
Articles in this Issue
Correction: Several supplementary concepts for applied category-theoretical states over an extended Petri net using an example relating to genetic coding: Toward an abstract algebraic formulation of molecular/genetic biology
The longitudinal relationship between depression and anxiety in colorectal cancer patients undergoing chemotherapy and family caregivers: A cross lagged panel model
Background Family caregivers play a crucial caregiving role for colorectal cancer patients undergoing chemotherapy, and the emotional states of both patients and caregivers can influence each other. A...
Scutellaria Barbata inhibits epithelial-mesenchymal transformation through PI3K/AKT and MDM2 thus inhibiting the proliferation, migration and promoting apoptosis of Cervical Cancer cells
Background Cervical cancer is the fourth most common malignant tumor among women with high morbidity and mortality. We found the active ingredients, action targets and pathways of Scutellaria Barbata...
Factors associated with regional differences in healthcare quality for patients with acute myocardial infarction in Japan
Background The quality of healthcare at the regional level is of great interest. Regional differences in the quality of healthcare for cardiovascular diseases have been pointed out...
Exploring access to social protection by persons with disabilities in Bangladesh
Background Social protection programs have played a significant role in ensuring that persons with disabilities (PWD) in low- and middle-income countries have access to basic livelihoods. However, the...
Temporal and interaction dynamics of dengue cases, entomological and meteorological variables in Melaka, Malaysia: A multivariate time series analysis
The complex interaction between dengue cases, entomological and meteorological variables has posed challenges for decades. Validated and updated evidences are in need for enhancing surveillance and ve...
Contributory factors to reporting distance as a barrier to health facility visit among reproductive-age Senegalese women: A survival analysis
Background The burden of distance to healthcare facility is a factor of maternal morbidity and mortality in resource-constrained settings. In Senegal, little is known about distance or travel time as...
Establishment of a simple prediction method for DNA melting temperature: high-resolution melting curve analysis of PCR products
High-resolution melting analysis is a technique that leverages the principle that the thermal stability of dsDNA is influenced by its length and base composition. This method generates a melting curve...
Association between medication adherence and cardiovascular outcomes in patients with both diabetes and hypertension in primary care settings in Canada: A retrospective cohort study
Objectives The impact of concurrent adherence to antihypertensives, antidiabetics, and statins on cardiovascular disease (CVD) outcomes and intermediate clinical outcomes in people with hypertension a...
Novel empirical models & comparative probabilistic analysis of interconnectedness of volcano eruption & nearby earthquakes
This paper takes a probabilistic approach to validate novel empirical models and the directional distributional similarities of nearby earthquake counts related to a typical volcano with its eruption...
Awareness of periodontitis and its relationship with systemic health among undergraduate medical students at a teaching hospital in Nepal: A cross-sectional study
Background Periodontitis is a multifactorial chronic inflammatory disease primarily caused by bacterial plaque, but may be affected by the host immune response, diabetes, inadequate nutrition, smoking...
Live streaming mode selection strategy under the background of virtual anchor supplementation
In the context of virtual anchors as a supplement to human anchors in live streaming e-commerce. In this paper, for the first time, virtual anchors are included in the live streaming mode selection st...
Target sample mining with modified activation residual network for speaker verification
In the domain of speaker verification, Softmax can be used as a backend for multi-classification, but traditional Softmax methods have some limitations that limit performance. During the training phas...
The Association between PTPN22 SNPs and susceptibility to type 1 diabetes: An updated meta-analysis
Type 1 diabetes (T1D) is a significant global health concern, characterized by the autoimmune destruction of insulin-producing pancreatic β-cells, resulting in lifelong dependence on insulin therapy....
Population structure of yellowtail snapper using age-based life history and otolith shape in southern Gulf of México
Yellowtail snapper Ocyurus chrysurus is commercially important throughout its distribution range. In southern Gulf of México, it is caught as part of a largely undocumented multispecific snapper fishe...
Evaluation of Onco E6 point of care rapid diagnostic test for human papilloma virus in Bahir Dar, Amhara Regional State, Ethiopia
Introduction Cervical cancer is a malignant tumor arising from the cells of the uterine cervix. The oncogenic human papillomavirus (HPV) infection is the main causative agent of cervical cancer. Effec...
A phylogenomic perspective reveals mitochondrial-nuclear discordance and previously undescribed species nested within a widespread East African Reed frog species (Hyperolius substriatus Ahl, 1931)
The sub-montane East African Reed Frog, Hyperolius substriatus Ahl, 1931 (Spotted Reed Frog) has a fragmented highland distribution throughout East Africa. Previous studies show extensive mitochondria...
New U-Pb constraints and geochemistry of the East Kirkton Quarry, Scotland: Implications for early tetrapod evolution in the Carboniferous
The transition of vertebrates from aquatic to terrestrial environments during the late Devonian to early Carboniferous marks a crucial evolutionary milestone. However, this transition remains poorly u...
A comparison of fit, heat stress, oxygen saturation and comfort between a novel reusable mask and disposable N95 respirator
The effectiveness of face masks in infection prevention depends not only on filtration technology but also on user compliance. However, existing masks suffer from limitations impacting comfort, ease o...
A novel decision ensemble framework: Attention-customized BiLSTM and XGBoost for speculative stock price forecasting
Forecasting speculative stock prices is essential for effective investment risk management and requires innovative algorithms. However, the speculative nature, volatility, and complex sequential depen...
Experimental study on the effect of Ivermectin on cattle dung faunas in Eastern Ethiopia
An experimental investigation was conducted from December 2023 to June 2024 at the beef farm of Haramaya University. The bulls were divided into two groups: one group received ivermectin treatment, wh...
Optimal control analysis for the transmission of Nipah infection with imperfect vaccination
This paper presents an innovative mathematical model for assessing the dynamics and optimal control of Nipah virus (NiV) with imperfect vaccination. The model formulation considers transmissions throu...
Factors associated with the survival of adults with COVID-19 using a high-flow nasal cannula in a tertiary hospital in northern Peru during the second wave of the pandemic
Objectives To identify factors associated with survival in patients admitted to the intensive care unit (ICU) for COVID-19 who used high-flow nasal cannula (HFNC) in a tertiary hospital in northern Pe...
Protocol for a prospective cohort study on congenital heart disease in neonates across varied altitudes in Sichuan province, China
Congenital heart disease (CHD) is the most prevalent congenital disorder, contributing significantly to neonate mortality. Despite advances in diagnosis and treatment, the incidence and risk factors o...
Evaluation and Characterization of Acute respiratory distress syndrome in tree shrews through TMT proteomic method
Acute respiratory distress syndrome (ARDS), a common cause of acute fatal respiratory, is characterized by severe inflammatory lung injury as well as hallmarks of increased pulmonary vascular permeabi...