PLoS ONE
Articles in this Issue
Risk factors associated with adverse outcomes after cervical conization in patients with cervical adenocarcinoma in situ
Background Identifying high-risk groups for adverse outcomes after conization is crucial for developing targeted treatment plans for patients with cervical adenocarcinoma in situ (ACIS). This study ai...
The hepatic transcriptome is differentially regulated by a standardized meal in healthy individuals compared to patients with fatty liver disease
The human liver is dynamic organ with minute to hourly adaptions in response to feeding. Patients with non-alcoholic fatty liver disease (NAFLD) and cirrhosis have altered transcriptomic features comp...
The CLASS (Cerebral visual impairment Learning and Awareness for School Staff) Pilot Study: An evaluation of the awareness of CVI amongst teachers and comparative evaluation of two different educational resources on understanding
Cerebral visual impairment (CVI) is the leading cause of visual impairment in children in high income countries. Despite its prevalence, awareness of CVI among educators remains low, meaning that many...
Measuring Child Labor: The Who’s, the Where’s, the When’s, and the Why’s
Measuring child labor accurately is a major challenge: parents’ and children’s reports tend to differ dramatically, and there is typically no way to verify whose reports are truthful (if any). To over...
The joint effect of weight-adjusted waist index and physical activity on all-cause mortality in Chinese elderly patients with multimorbidity: A study based on the CLHLS from 2011 to 2018
Background The relationship between physical activity changes, weight-adjusted waist circumference index (WWI), and mortality risk among older Chinese adults with multimorbidity remains unclear. This...
Empowering safety managers to champion the implementation of smoking cessation services in the construction industry: Protocol for a sequential multiple assignment randomized trial
US construction workers (CWs) have the highest cigarette smoking rate among all occupations (27.2% vs. 15%), yet the lowest coverage of workplace smoking cessation services (14% vs. 29%). This study a...
Variant evolution graph: Can we infer how SARS-CoV-2 variants are evolving?
The SARS-CoV-2 virus has undergone extensive mutations over time, resulting in considerable genetic diversity among circulating strains. This diversity directly affects important viral characteristics...
“We’re here to help them if they want to come”: A qualitative exploration of hospital staff perceptions and experiences with outpatient non-attendance
Background Patient non-attendance remains a major challenge for health services. Few studies have examined how health service providers think about, potentially address, and prioritise non-attendance...
In silico analysis of quorum sensing modulators: Insights into molecular docking and dynamics and potential therapeutic applications
Quorum sensing (QS) regulates bacterial functions like virulence and biofilm formation, mediated by proteins such as LasI and QscR in Pseudomonas aeruginosa. This study investigates the structural dyn...
Investigating methods to enhance interpretability and performance in cardiac MRI for myocardial scarring diagnosis using convolutional neural network classification and One Match
Machine learning (ML) classification of myocardial scarring in cardiac MRI is often hindered by limited explainability, particularly with convolutional neural networks (CNNs). To address this, we deve...
Correction: Hyper-induction of IL-6 after TLR1/2 stimulation in calves with bovine respiratory disease
Cardiovascular disease risk among Australian unpaid carers – A survival analysis using 15 waves of the HILDA survey
Background Engaging in chronically stressful behaviours has been hypothesised to increase the risk of experiencing cardiovascular disease (CVD). Providing unpaid care is known to be a stressful activi...
Utilizing Multi-omics analysis to elucidate the role of mitochondrial gene defects in Gastric cancer progression
Background Gastric cancer is a leading cause of cancer-related mortality worldwide, with poor survival outcomes despite advances in diagnostic and therapeutic methods. Mitochondrial autophagy, or mito...
Kinesthetic illusions induced by muscle tendon vibration: The orientation of the vibration motor as a new methodological factor?
Purpose/aim To investigate the impact of changing the rotational orientation of the vibrating motor on kinesthestic illusions. Materials and methods Twenty healthy individuals received vibration ove...
A provably secure coercion-resistant e-voting scheme with confidentiality, anonymity, unforgeability, and CAI verifiability
Ensuring both cast-as-intended (CAI) verifiability and coercion-resistance in e-voting remains a critical challenge. The e-voting scheme proposed by Finogina and Herranz in 2023 represents the first n...
Enhanced Surveillance for Meningococcal Disease—United States, 2015–2019
Background High quality surveillance data are important to monitor U.S. epidemiology of meningococcal disease. Enhanced Meningococcal Disease Surveillance (EMDS) was established in 2015 to collect add...
24-hour movement behaviours and mental health in non-clinical populations: A systematic review
The 24-hour movement guidelines consider movement behaviours (sleep, exercise, sedentary time) together within the frame of our 24-hour limit to provide recommendations on how a physically healthy day...
Aldo-keto reductase family 1 member C3 (AKR1C3) gene polymorphism (rs12529) is associated with breast cancer in Bangladeshi population: A case-control study and computational investigation
Breast cancer is defined as the unchecked growth of breast cells, with imbalances in prostaglandin and steroid hormone metabolism contributing to disease risk by altering prostaglandin types and forms...
Absence of item origin bias on a Brazilian interinstitutional Progress Test examination: A pooled analysis of items approach
Background It has been proposed that the school origin of items for cross-institutional Progress Tests (PTs) may introduce a bias in favour of students from the same school, posing a potential threat...
Diabetes rescue, engagement, and management (D-REM) for hypoglycemia: Clinical trial protocol of a community paramedic program to improve diabetes management among adults with severe hypoglycemia
Background Diabetes is among the most prevalent chronic conditions in the United States. Challenges in optimal diabetes care include fragmented care, gaps in diabetes self-management education, and hi...
Impact of mtG3PDH inhibitors on proliferation and metabolism of androgen receptor-negative prostate cancer cells: Role of extracellular pyruvate
Mitochondrial glycerol 3-P dehydrogenase (mtG3PDH) plays a significant role in cellular bioenergetics by serving as a rate-limiting element in the glycerophosphate shuttle, which connects cytosolic gl...
A qualitative exploration into the experience of mindfulness in moderate-severe persistent depression
Depression is a common and growing mental health problem, with around 5% of the world’s population experiencing an episode of depression during their lifetime. Relapse rates are high, with around half...
Comparison of lesion segmentation performance in diffusion-weighted imaging and apparent diffusion coefficient images of stroke by artificial neural networks
Stroke is the second leading cause of death, accounting for 11% of deaths worldwide. Comparing diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) images is important for stroke...
Designed for simplicity, used for complexity: The systemic pressures shaping walk-in clinic practices and outcomes
Walk-in clinics (WICs), appreciated for their accessibility and convenience, have become an increasingly popular healthcare option in Ontario for patients with and without primary care enrolment. Desp...
The impact of wartime conflict on the mental health problems of women in the conflict-hit population in Woldia, Ethiopia
Background Common mental health problems are of significant public health importance, with severe social and economic impacts that adversely affect individuals’ quality of life. The burden of these pr...