PLoS ONE
Articles in this Issue
Breathing therapy for patients with medically unexplained physical symptoms and dysfunctional breathing: A pilot and feasibility trial
Medically unexplained physical symptoms (MUPS) are symptoms without an identifiable organic cause that lead to functional impairment. MUPS is highly prevalent in general practice consultations. This p...
Adverse event profile differences among long-acting gonadotropin-releasing hormone analogs: A real-world, pharmacovigilance study
Background Long-acting Gonadotropin-releasing hormone analogs(GnRHa), including leuprolide, goserelin, histrelin, buserelin, triptorelin, have been widely used for a variety of diseases including pros...
Psychometric properties of the exercise self-efficacy scale in patients with chronic obstructive pulmonary disease
Objectives This study explores the psychometric properties of the Exercise Self-Efficacy (ESE) scale among individuals with Chronic Obstructive Pulmonary Disease (COPD). The secondary objective was to...
Association between self-administrated prophylactics and SARS-CoV-2 infection among traditional market vendors from the Central Highlands of Peru: A nested case-control study
Although COVID-19 is no longer a public health emergency of international concern, understanding behaviours such as self-medication remains relevant for informing future outbreak responses and improvi...
Parental preferences for sex of children in Nigeria: Cultural influences and family structure
Background Nigeria is characterized by deeply rooted traditional practices that often amplify gender bias. Despite this, there is limited research examining the relationship between cultural and famil...
Spontaneous recanalization of extracranial internal carotid occlusion: A systematic scoping review
Introduction The spontaneous recanalization of an occluded extracranial internal carotid artery (ICA) is thought to be an uncommon etiology of ischemic stroke. However, a growing number of reports des...
Retraction: MMP-9, uPAR and Cathepsin B Silencing Downregulate Integrins in Human Glioma Xenograft Cells In Vitro and In Vivo in Nude Mice
Dual effects of indoxyl sulfate on modulation of human hepatic CYP3A activity, with individual differences
This study aimed to identify gut microbiota-derived metabolites governing the activity of hepatic CYP3A in blood level. Indole propionic acid (IPA) and lithocholic acid, ligands of the pregnane X rece...
Green tea consumption rapidly enhances cognitive performance and flow state during mental tasks in healthy young adults
This study examined green tea’s effects on task performance, mental fatigue, workload, and flow experience. Twenty-two healthy young male participants (mean ± SD age = 21.86 ± 1.96 years, range = 18–2...
Coarse-grained molecular dynamics investigation on the interaction between κ- and β-casein aggregates and curcumin
A behaviour change intervention promoting physical activity following dysvascular amputation: Protocol for a pilot study
Background Diabetes-related lower limb amputation (LLA) is a leading cause of disability globally, impacting individuals’ physical and mental health, and ultimately their quality of life. Physical act...
Monitoring cognitive resilience in military personnel in extreme operational environments: The role of smart technologies and nutritional strategies—A scoping review protocol
Introduction Maintaining cognitive performance in extreme operational environments is essential for military personnel efficiency. Exposure to multiple stressors, including sleep deprivation, intense...
In silico identification of promising PD-L1 inhibitors from selected indian medicinal plants for treatment of triple negative breast cancer
Triple-negative breast cancer (TNBC) is the most aggressive among the breast cancer subtypes and poses unique therapeutic challenges due to its distinct characteristics like lack of specific therapeut...
EBV-miR-BART5-5p regulates RORA to promote proliferation and migration of gastric cancer cells
Background Epstein-Barr virus-associated gastric cancer (EBVaGC) represents a distinct molecular subtype of gastric cancer. EBV encodes various viral RNAs, including BamHI-A rightward transcripts (BAR...
LSTM-based prediction method for shape error of steel truss during incremental launching construction
Accurate shape control during steel truss incremental launching remains a persistent challenge in bridge engineering, primarily due to dynamic geometric variations induced by continuous spatial transl...
MiR-122 promotes metastasis of hepatoma cells by modulating RBM47-integrin alpha V-TGF-beta signaling
MiR-122 is a liver-abundant miRNA, which is thought to harbor antitumorigenic activity. Elevated transforming growth factor-β (TGF-β) in hepatocellular carcinoma (HCC) microenvironment is a potent ind...
Diversity, distribution, and population structure of Escherichia coli in the lower gastrointestinal tract of humans
Several studies report the diversity, and population structure of Escherichia coli (E. coli) in the human gut, but most used faecal specimens as the source of E. coli for analysis. In the present stud...
Editorial Note: Hand hygiene practices during the COVID-19 pandemic and associated factors among barbers and beauty salon workers in Ethiopia
Stress and job satisfaction among nursing faculties in academic institutions in Nepal: A cross-sectional comparison between government and private institutions
Background Stress and job dissatisfaction are significant factors leading to reduced efficiency and loss of human resources in all sectors, especially nursing education. This study aimed to compare th...
Using a non-surgical transcutaneous intraglandular injection technique to deliver cell and cell-free therapies to murine submandibular salivary glands
Salivary Glands (SGs) are vital organs that are particularly prone to damage due to head and neck cancer radiation treatment, as well as other autoimmune disorders. SG hypofunction often impairs the p...
Effectiveness of implementation strategies for uptake of fall prevention interventions in community care: A systematic review
Introduction Falls among older adults are one of the leading causes of morbidity and mortality in this population and pose a significant economic burden on society. Despite substantial evidence suppor...
Emergence of a new me: Experiences of women diagnosed with HER2-positive breast cancer
Breast cancer subtypes vary in prevalence, prognosis, treatment protocols, and side-effect profiles, that may impact patients’ lived experiences. Despite this, studies often group the experiences of p...
Prevalence and risk factors of antimicrobial resistance patterns of Staphylococcus spp. and E. coli in rodents and shrews at human-animal interfaces in Chattogram, Bangladesh
Antimicrobial resistance (AMR) poses a significant threat to human and animal health worldwide. Wild rodents and shrews may serve as bioindicators of environmental health. They may serve as a potentia...
BN-SNN: Spiking neural networks with bistable neurons for object detection
Spiking neural networks (SNNs) are emerging as a promising evolution in neural network paradigms, offering an alternative to conventional convolutional neural networks (CNNs). One of the most effectiv...
Exploration of effective pharmacological inhibitors for NS5 protein through computational approach: A strategy to combat the neglected Kyasanur forest disease virus
Kyasanur Forest Disease Virus (KFDV) poses a significant public health threat due to the limited efficacy of existing vaccines, necessitating the development of effective antiviral therapeutics. The n...