PLoS ONE
Articles in this Issue
ProProtein: A platform for fully automated identification of 3D structure fluctuations in MD simulation trajectories
The main goal of Molecular Dynamics (MD) is a simulation of a physical system motions in a fixed time period. This technique allows users to observe the dynamic evolution of the system but requires ad...
Quantification of H3.1-nucleosomes using a chemiluminescent immunoassay: A reliable method for neutrophil extracellular trap detection
Neutrophil extracellular traps (NETs) are chromatin-based web-like structures released by activated neutrophils in response to infectious agents. Overproduction or insufficient clearance of NETs contr...
RETRACTED: A 12,800-year-old layer with cometary dust, microspherules, and platinum anomaly recorded in multiple cores from Baffin Bay
The Younger Dryas Impact Hypothesis (YDIH) posits that ~12,800 years ago Earth encountered the debris stream of a disintegrating comet, triggering hemisphere-wide airbursts, atmospheric dust loading,...
Spectrum of urolith composition among a multi-ethnic population at the Aga Khan hospital, Dar-es-Salaam, Tanzania
Background Urolithiasis is among the commonest diseases affecting the urinary tract with worldwide prevalence varying from 1%−20%. A urolith refers to a calculus or stone within the urinary tract, kno...
Prevalence and associated factors of overweight and obesity among reproductive-aged women (15–49 years) in Ratnanagar Municipality, Chitwan district, Nepal
Background Overweight and obesity is a rising public health threat both in developed and developing countries including Nepal. Nepal is undergoing rapid urbanization, accompanied by significant change...
Personality traits and resilience mediated by depressive symptoms in a sample of psychotherapy patients: A cross-sectional study
Introduction Resilience is a concept that has been widely studied in different contexts and is related to adaptation to different stress levels. Although research in psychotherapy has produced vast kn...
Efficacy of MRI and clinical findings of Lidocaine injection combined with manual therapy in frozen shoulder—A prospective, randomized, single-blinded, sham-controlled trial
Background Frozen shoulder, or adhesive capsulitis, is a debilitating condition characterized by progressive pain and restricted range of motion in the glenohumeral joint. A wide range of intervention...
User preferences in multi-objective routes: The role of gradient visualization and personality measures
Traditional pedestrian navigation systems typically prioritize the shortest or fastest routes. However, modern urban environments require multi-objective navigation that incorporates factors such as r...
Examination of the spatial-temporal variations in terrestrial water reserves and green efficiency of water resources in China’s three northeastern provinces
Using technological advancements and analyzing urban water consumption patterns, this article employs GRACE satellite data and statistical records to conduct a comprehensive assessment and evaluation...
Analysis of multipath effects in global trade networks based on multimodal, high dimensional, heterogeneous transformer architecture: Deconstruction of nonlinear cascade and dynamic chain reaction
This paper proposes a multi-path effect analysis model for major economies in the global trade network based on the MH-DP Transformer architecture. The global trade network comprises interconnected no...
Psychological distress among parents with emigrant offspring: A mixed-methods study from Changunarayan Municipality, Nepal
Background The growing trend of international migration has significant socio-emotional implications for families left behind, particularly the left-behind parents. While much research focuses on the...
Editorial Note: Enhancing shipyard transportation efficiency through dynamic scheduling using digital twin technology
Unveiling health disparities: Diagnostic prevalences in a transgender cohort versus matched controls
Importance Transgender and gender-diverse (TGD) individuals are at risk for discrimination and inequities across legal, social, and medical contexts. Population-level resources have rarely been used f...
Quality of life in a family-centric applied behavior analysis model: A case series study
Autism spectrum disorder (ASD) is a condition with growing prevalence that results in significant healthcare spending, reduced parent income, high levels of family stress, and decreased quality of lif...
Can cognitive function tests discriminate between patients with glioma and healthy controls prior to treatment? A systematic review
Background Brain tumours affect 7 per 100,000 people in the UK, glioma being most prevalent, with only 12% five-year survival rates and devastating impacts. Primary care triage tools could facilitate...
Application of mechanical quantitative techniques in postoperative rehabilitation assessment of anterior cruciate ligament reconstruction: A study protocol
This study protocol aims to explore the application of mechanical quantitative techniques in the postoperative rehabilitation assessment following anterior cruciate ligament reconstruction (ACLR). Ant...
An unexpected role of CLASP1 in radiation response and S-phase regulation of head and neck cancer cells
Radiotherapy is a mainstay of treatment for head and neck squamous cell carcinoma (HNSCC), either definitive or adjuvant to surgery. Biological factors known to affect radiation response are hypoxia a...
Precision medicine in rheumatoid arthritis: Evaluation of a new approach to predict clinical response to methotrexate in patients with early rheumatoid arthritis
Background International guidelines recommend methotrexate (MTX) as the first-choice treatment in rheumatoid arthritis (RA). Although most patients with recently diagnosed arthritis achieve low diseas...
Hyperuricemia in ob/ob mice relates to hepatocellular pyruvate metabolism/ xanthine oxidase axis
Objective The study aimed to examine the association between obesity and hyperuricemia in ob/ob mice. Methods An animal model of obesity was developed using male ob/ob mice. Biochemical parameter te...
Protocol for a scoping review of the evidence concerning the unique needs and experiences of Orthodox Jewish women and their partners using maternity services
Background Orthodox Jews follow the Jewish law, Halacha, that determines most daily activities and behaviours. Halacha restrictions and the insular lifestyle of groups within the Orthodox community ha...
The influence of audience’s regulatory focus on the persuasive effect of different pro-vaccine messages
The aim of this study was to investigate the influence of an audience’s regulatory focus on the persuasive effect of different pro-vaccine messages. Study 1 (N = 169) examined attitude changes among a...
DNA methylation differences stratified by normalized fetal/placental weight ratios suggest neurodevelopmental deficits in neonates with congenital heart disease
Background We lack early biomarkers for predicting neurodevelopment (ND) outcomes in children with congenital heart disease (CHD). Placentas of fetuses with CHD have abnormalities, including unbalance...
Factor structure and psychometric properties of the Hungarian version of the Mentalized Affectivity Scale (MAS): A cross-sectional study
Background There is an increasing need among researchers to explore how emotions are regulated and processed. Mentalized affectivity is a complex cognitive and affective ability to understand thoughts...
Reproductive health programs in women with physical disabilities: A scoping review protocol
Introduction Approximately 15% of people with disabilities are women of reproductive age. Women with physical disabilities are neglected in reproductive and sexual health. Complex health conditions, m...
Association of 25(OH)D serum level with biological aging: A Cross-Sectional Study of 2007–2016 NHANES surveys
Vitamin D plays a crucial role in various aspects of human body, including aging, but chronological age may not accurately reflect the true biological aging status. Recently, PhenoAge has been develop...