PLoS ONE
Articles in this Issue
Mechanism of Huanglian Wendan Decoction in ameliorating non-alcoholic fatty liver disease via modulating gut microbiota-mediated metabolic reprogramming and activating the LKB1/AMPK pathway
Background Huanglian Wendan Decoction (HLWDD), a classical traditional Chinese medicine (TCM) formula, has shown therapeutic promise in treating metabolic disorders. However, its underlying mechanisms...
Efficacy of Pulsatilla saponin B4 for treatment dairy cows affected with clinical mastitis
In order to explore the therapeutic effect of natural compound Pulsatilla saponin B4 (PSB4) on clinical mastitis (CM) in dairy cows, 40 dairy cows with CM and 20 healthy dairy cows were selected as ex...
The relationship between artistic skills and academic engagement among artistically gifted non-specialist university students
Background This study aimed to investigate the level of artistic skills and academic engagement among artistically gifted non-specialist students at Prince Sattam bin Abdulaziz University, Saudi Arabi...
Citizen science reveals alarming update on the invasion of the Asian mantleslug Meghimatium pictum in Brazil
The Asian mantleslug Meghimatium pictum is an exotic species introduced to Brazil in the late 1990s, but only formally reported in 2011. Since then, it has been deemed an agricultural pest and given t...
Rupture risk assessment for AComA aneurysms with morphological, hemodynamic and structural mechanical analysis
Introduction The Anterior Communicating Artery complex (AComA) is one of the most common intracranial aneurysms locations. Accurate rupture risk assessment in patients with cerebral aneurysms is essen...
Computational prediction of high-risk non-synonymous SNPs in human ApoE and their structural impact on amyloid-β interaction in Alzheimer’s disease pathogenesis
Apolipoprotein E (ApoE) plays a critical role in Alzheimer’s disease (AD) by regulating amyloid beta (Aβ) clearance through direct interaction. Non-synonymous single nucleotide polymorphisms (nsSNPs)...
Crush syndrome diagnosis and management in resource-constrained settings: A Delphi study
Background Crush syndrome is an important source of morbidity and mortality in resource-constrained settings including earthquake disaster zones, austere military environments, and countries where mot...
SEE+ computerized classroom-based training enhances 7- to 10-year-olds' socio-emotional cognition through observation and inference
Smooth social interactions rely on children’s abilities to decode others’ social signals, which includes what an individual may say or do, and their facial emotional expressions. Failure can lead to e...
Deep learning detection of retinal detachment: Optical coherence tomography staging and estimation of duration of macular detachment
Objective To test the applicability of deep learning models for detecting and staging rhegmatogenous retinal detachment (RRD) based on morphological features using two- and three-dimensional optical c...
CUB domain-containing protein 1 signaling dysregulates gemcitabine metabolism contributing to therapeutic resistance in T24 cells
Gemcitabine is commonly used in the standard first-line treatment of urothelial carcinoma (UC); however, the emergence of drug resistance significantly limits its clinical benefit. The present study a...
Suicide literacy and stigma among undergraduate students in Pokhara, Nepal: A cross-sectional study
Background Suicide is a major global public health concern, with stigma and low suicide literacy posing significant barriers to prevention and intervention. Despite increasing suicide rates and concer...
DE-HRNet: Detail enhanced high-resolution network for human pose estimation
Scale variation is a challenge in human pose estimation. The scale variations of human body are related to the accuracy and robustness of posture estimation. For example, the prediction accuracy of sm...
Proxies for use in biochar decay models: Hydropyrolysis, electric conductivity, and H/Corg molar ratio
Biochar is a carbon-rich material produced via pyrolysis that is increasingly recognized for its role in carbon sequestration, particularly through its application in agriculture and materials. Howeve...
Improving attachment style clustering with ROCKET and CatBoost: Insights from EEG analysis
Understanding attachment styles is essential in psychology and neuroscience, yet predicting them using objective neural data remains challenging. This study explores the use of machine learning (ML) m...
Research on the U-shaped relationship between marketization process and corporate capital structure: Evidence from Chinese listed companies
This paper explores the U-shaped relationship between marketization and corporate capital structure using panel data from Chinese listed firms (2012–2021). Applying fixed effects and nonlinear regress...
Effects of mentoring on self-reflection and competence in Final year medical students’ internal medicine rotation
Background Final year medical students (FYMS) in Germany transfer theoretical knowledge to clinical practice. However, there is a deficiency in structured guidance and feedback and self-reflective pra...
A cytotoxic peptide-drug conjugate for tumor-specific delivery of co-injected molecules
An ideal cancer therapy enhances anti-tumor effects while minimizing side effects. iRGD, a non-cytotoxic peptide that activates a tumor-specific molecular transport machinery, promotes the penetration...
Effect of sensory art therapies on root canal treatment anxiety and high dental anxiety in adults: A systematic review with meta-analysis
Objective Root canal treatment is one of the most anxiety-provoking procedures in dental practice. Sensory art therapies can help control patient anxiety during the procedure. This systematic review a...
The Spurious Prospective Associations Model (SPAM): Explaining longitudinal associations due to statistical artifacts
Analysis of longitudinal data often relies on models which can be prone to statistical artifacts. We have previously shown that several published prospective associations can be explained by a combina...
Effectiveness of Peer-assisted learning in medical education: A meta-analysis study
The objective of this meta-analysis was to compare the effects of peer-assisted learning (PAL) and traditional teaching methods on the theoretical knowledge and practical skill education in clinical m...
Understanding perceived value in tourism: Insights from destinations facing crises
Tourism is a significant contributor to global economic growth, underscoring the importance of understanding visitors’ perceptions of attractions in destinations that face challenges and crises. This...
Digital soil mapping in support of voluntary carbon market programs in agricultural land
Voluntary carbon market (VCM) programs in agriculture depend on accurate measurements of soil organic carbon (SOC) that can be deployed at scale efficiently, but barriers are preventing widespread ado...
Subjective socioeconomic status moderates depression’s impact on fairness perception in the ultimatum game: A moderated mediation model
Individuals with depression often exhibit cognitive distortions in socioeconomic decision-making, particularly in interpreting fairness. However, the role of subjective socioeconomic status in shaping...
Burden of tuberculosis in Eastern Africa region from 1990–2021: A systematic analysis for the Global Burden of Disease 2021 Study
Background Tuberculosis (TB), despite being a preventable and curable disease, remains a leading infectious cause of death. In Eastern Africa, TB poses a significant public health challenge. This stud...