Journal of Clinical Oncology
Articles in this Issue
Association between chemotherapy use and clinical outcomes in young BRCA carriers with T1N0 breast cancer: Results from an international cohort study.
541 Background: Systemic treatment decisions for young BRCA carriers with small node-negative breast cancers present unique challenges due to limited evid...
A randomized controlled trial of cognitive behavioral therapy and bright light therapy for insomnia and fatigue during breast cancer treatment: SleepCaRe trial.
12009 Background: Women on chemotherapy for breast cancer (BC) report high levels of insomnia and fatigue. This trial aimed to test the main effects of Co...
Quantifying clinical harm and financial waste from failure to deploy personalized medicine for patients with metastatic non-small cell lung cancer in the United States.
e20687 Background: Biomarker panel testing for newly diagnosed metastatic non-small cell lung cancer (mNSCLC) as recommended by the National Comprehensive...
Evaluation of the effectiveness and safety of disitamab vedotin for HER2-expressing advanced or recurrent gynecological cancers.
e17512 Background: Recent evolution of treatment landscape in advanced or recurrent gynecological cancers has led to novel treatments such as antibody-dru...
Evolving global burden and trend of cervical cancer in G20 countries: Age, sex, regional disparities from 1990-2021.
5541 Background: Cervical Cancer (CC) is the 6 th leading cause of death and 4 th leading cause of disabil...
A retrospective study assessing the efficacy of combined transarterial chemoembolization and microwave ablation in the treatment of large, unresectable hepatocellular carcinoma (≥5 cm).
e16274 Background: Unresectable large hepatocellular carcinoma (HCC) ≥5 cm without vascular invasion or extrahepatic metastasis, transarterial chemoemboli...
Multiomic analysis of cutaneous squamous cell carcinoma (cSCC) and association with response to anti-PD1 therapy (PD1).
9585 Background: PD1 induces a durable response and improves the survival of patients (pts) with advanced cSCC; however, about 40% of pts are resistant to...
Applying learning science principles (LSP) through a simulation session (SIM) for oncology trainees (OT) about fertility preservation (FP) in patients (pts) with cancer and treatment (tx) of pregnant pts (TPP) with cancer.
9029 Background: Addressing guideline concordant FP and TPP with cancer is challenging, especially for OT. SIM, a well-known education tool, has not been...
Income and location divide in myeloma outcomes: A call for equitable care.
e19544 Background: Myeloma, a hematologic malignancy with rising incidence, has seen significant advancements in treatment over the past two decades. Howe...
Surgical debulking versus non-surgical management for the control of carcinoid syndrome in metastatic small bowel neuroendocrine tumors.
4147 Background: Somatostatin analogues (SSAs) are first-line systemic therapeutics for tumor- and symptoms control in well-differentiated small bowel neu...
Global trends and regional disparities in young-onset breast cancer: Age-specific patterns from 1990 to 2021.
568 Background: Young-onset breast cancer (YOBC), defined as breast cancer in women under 40, is a growing global health concern with unique biological an...
Effects of marital status on survival in patients with colorectal cancer.
3628 Background: Demographic factors such as marital status have been shown to have differential effects on cancer outcomes. It has been shown that marrie...
Updated efficacy and safety of entrectinib in children with extracranial solid or primary central nervous system (CNS) tumors harboring <i>ROS1</i> fusions.
10050 Background: Entrectinib is a TRK and ROS1 inhibitor that has shown rapid and durable responses in children with NTRK1/2/3 or...
Outcomes of an electronic patient-reported outcomes (ePRO)–based symptom management program (eSyM): A cluster randomized trial.
11001 Background: Although ePROs have been shown to reduce resource utilization and improve outcomes among people with cancer, they have not been widely a...
RACED (Reduction of Cervical Cancer Disparities): The impact of navigators and racial literacy training.
TPS1660 Background: Cervical cancer is the third most prevalent cancer in Brazilian women. Approximately 17,000 new cases are expected for Brazil’s 2023-2...
Survival outcomes of Epstein-Barr virus-positive diffuse large B-cell lymphoma, not otherwise specified: Results from Latin American and United States cohorts.
7045 Background: Epstein-Barr virus-positive diffuse large B-cell lymphoma (EBV+ DLBCL), not otherwise specified, is rare in North America and Europe (2–4...
Hemoglobin level and neutrophil-to-lymphocyte ratio as prognostic peripheral blood markers of survival outcomes in sacituzumab govitecan therapy for mTNBC in Polish female cohort.
e13152 Background: Hemoglobin (Hb) level and the neutrophil-to-lymphocyte ratio (NLR) are key prognostic factors in breast cancer, influencing survival an...
Envafolimab and chidamide in combination with GEMOX as first-line treatment for advanced and metastatic biliary tract cancer (B-Enefits/SCOG-B001): A single-arm, exploratory, phase 2 trial.
e16231 Background: Biliary tract cancer (BTC) is a rare malignant tumor with poor prognosis. Envafolimab is a light-chain deficient PD-L1 antibody. Chidam...
Efbemalenograstim alfa for the primary/secondary prophylaxis of intermediate-risk febrile neutropenia (FN) chemotherapy regimen with risk factors in patients with non-small cell lung cancer (NSCLC): A randomized, multicenter, exploratory clinical trial.
e20560 Background: Neutropenia is a very common dose-limiting toxicity of chemotherapy. The extent and duration of neutropenia can variably affect the cli...
Implementation and execution of nationwide molecular tumor boards (MTBs) in resource-limited settings: The “Molecular Thursdays” initiative.
e13895 Background: The increased access to broad next-generation sequencing (NGS) panels in routine oncology care has created a demand for education in mo...
Immunotherapy in patients with early-stage microsatellite instable (MSI-H)/mismatch repair deficient (dMMR) colorectal cancer (CRC) treated in a community setting.
e15668 Background: MSI-H/dMMR cancers represent 10-15% of early-stage colorectal cancer (CRC) and respond well to immune checkpoint therapy. However, clin...
A randomized controlled trial comparing conversion surgery with palliative chemotherapy in patients with initially unresectable cStage IVB/pStage IV advanced gastric cancer who presented remarkable response to chemotherapy: JCOG2301 (Conversion study).
TPS4205 Background: Conversion surgery is a surgical treatment for patients with initially unresectable cStage IVB gastric cancer who presented remarkable...
Real-world (rw) study to identify disparities in outcomes for patients (pts) with early-stage resected NSCLC who received biomarker-targeted adjuvant treatment (BTRx).
8071 Background: BTRx improves survival of pts with resected early-stage NSCLC, making thorough biomarker testing critical in this setting. Disparities in...
Trends in mortality due to laryngeal carcinoma: A systemic analysis of the Global Burden of Disease 2021.
e18141 Background: Laryngeal cancer is among the most common respiratory system malignancies. While significant strides have been made in its treatment ov...
Real world data: Survival outcomes of patients with poor prognosis metastatic germ cell tumours (GCT) within a large tertiary UK centre.
e17021 Background: Patients categorised as having poor prognosis GCT, as per the International Germ Cell Cancer Collaborative Group (IGCCCG) risk classifi...