Journal of Clinical Oncology
Articles in this Issue
Pharmacokinetics and Safety of Selumetinib Granule Formulation in Children With Symptomatic, Inoperable Neurofibromatosis Type 1-Related Plexiform Neurofibromas (SPRINKLE; phase I/II)
PURPOSE Neurofibromatosis type 1 (NF1)–associated plexiform neurofibroma (PN) can substantially affect quality of life. The capsule and granule formulations...
Pediatric-Friendly Formulations: Critical to Maximizing Benefit of Novel Therapeutics Such as Selumetinib for Children With Neurofibromatosis and Other Neoplasms
Izalontamab Brengitecan in Locally Advanced or Metastatic Non–Small Cell Lung Cancer With Actionable Genomic Alterations Outside of Classical <i>EGFR</i> Mutations: A Phase Ib Study
PURPOSE To evaluate the safety and efficacy of izalontamab brengitecan (iza-bren) in patients with non–small cell lung cancer (NSCLC) harboring actionable ge...
Reply to: Focal Boosting in Localized Prostate Cancer in the Era of Systemic Therapy and Prostate-Specific Membrane Antigen Imaging
Gene Therapy–Related Malignancy and the Risk of Cancer Exceptionalism
Incremental Progress in the Cervical Cancer Screening Revolution
Pivekimab Sunirine in Blastic Plasmacytoid Dendritic Cell Neoplasm
PURPOSE Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a unique myeloid malignancy with CD123 interleukin-3 receptor-α overexpression and poor prognosis....
Treatment of Multiple Myeloma: ASCO–Ontario Health (Cancer Care Ontario) Living Guideline
This guideline has been updated. This ASCO Living Guideline is reviewed on an eight-week cycle. Please see the...
Quiet Work of Clarity
An ophthalmology resident discovers how vision care can honor end-of-life goals, helping a cancer patient with failing sight write to his children while considering how and when such letters should be...
Survival Outcomes With or Without Risk-Reducing Mastectomy in <i>BRCA1</i> and <i>BRCA2</i> Pathogenic Variant Carriers
PURPOSE Many women carrying pathogenic variants (pvs) of BRCA1 and BRCA2...
Risk of Breast Cancer After Ovarian Cancer in Women With a Pathogenic/Likely Pathogenic Variant in <i>BRCA1</i> or <i>BRCA2</i>
PURPOSE BRCA carriers face high risks of developing both breast and ovarian/fallopian tube cancers (hereafter referred to as...
Focal Boosting in Localized Prostate Cancer in the Era of Systemic Therapy and Prostate-Specific Membrane Antigen Imaging
Long-Term Prospective Cohort Study of Cervical Cancer Screening Using Triage of Women Who Are Human Papillomavirus–Positive With Dual Stain and Human Papillomavirus Genotyping
PURPOSE Primary human papillomavirus (HPV) testing has the best tradeoff of benefits and harms for cervical screening but requires triage to determine management among HPV positive...
Past, Present, and Future of Dexamethasone in Multiple Myeloma and AL Amyloidosis
For over half a century, dexamethasone has been a backbone of treatment regimens for plasma cell disorders such as multiple myeloma (MM) and light-chain (AL) amyloidosis. Dexamethasone doses of approx...