Journal of Clinical Oncology
Articles in this Issue
An 8-year single institution review of demographic trends and treatment patterns among patients with anaplastic thyroid carcinoma.
e18139 Background: Anaplastic thyroid carcinoma (ATC) is a rare entity with a dismal overall survival (OS) of <6 months. While historically, patients a...
Comparative survival outcomes among histological subtypes of pulmonary adenocarcinoma: A nationwide study.
e20066 Background: Adenocarcinoma of the lung is a heterogeneous malignancy with multiple histological subtypes. In the US, population survival outcomes a...
IDeate-PanTumor02: A phase 1b/2 study to evaluate the efficacy and safety of ifinatamab deruxtecan (I-DXd) in patients (pts) with recurrent or metastatic solid tumors.
TPS3157 Background: B7-H3 is highly expressed in many solid tumors but has limited expression in normal tissues; high B7-H...
Treatment-related neutropenia as a predictor of response to adjuvant palbociclib in the PALLAS trial (ABCSG-42/AFT-05/BIG-14-13/PrE0109).
526 Background: The PALLAS trial (NCT02513394) investigated the efficacy of the addition of palbociclib (palbo) to standard adjuvant endocrine therapy (ET...
Unmasking the link between sleep apnea and lung cancer risk: A retrospective propensity-matched cohort study.
10558 Background: Obstructive sleep apnea (OSA) is a prevalent disorder characterized by intermittent hypoxia, systemic inflammation, hypercapnia, and oxi...
Promoting resilience in stress management within patients with early stage breast cancer.
12109 Background: Women with breast cancer often experience persistent psychological distress, including fear of recurrence, which can be exacerbated in m...
Neoadjuvant biomarker trial of pepinemab to enhance nivolumab or ipilimumab activity in resectable head and neck cancer.
103 Background: Neoadjuvant treatment with immune checkpoint blockade (ICB) improves clinical benefit in patients with multiple types of cancers. Window o...
Oropharynx cancer in the US: Racial disparities in stage at presentation.
e13766 Background: Global occurrence of oropharynx cancer (OPC) varies greatly. While rare in the US, the diverse nature of the US clinical environment –...
Transformer-based deep learning model for integrated pathomics and radiomics in predicting postoperative survival of intrahepatic cholangiocarcinoma patients.
e16328 Background: Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive malignancy with a dismal prognosis. While surgical resection stands as the...
Novel dendritic cells-targeting mRNA-LNP vaccine with potent anti-tumor activity in vivo.
e21514 Background: Cancer vaccines have demonstrated limited efficacy in solid tumors with low immunogenicity. As the main antigen presenting cells, Dendr...
HIF family transcription factor expression in a cohort of 4362 patients with renal cell carcinoma (RCC).
4543 Background: The HIF pathway drives RCC pathogenesis operating through transcription factors (TFs) that function as heterodimers of the oxygen-sensiti...
Phase Ib/II study of fluzoparib in combination with dalpiciclib in patients with locally advanced or metastatic sarcoma.
11533 Background: Poly ADP-ribose polymerase (PARP) plays a role in DNA damage repair, and PARP inhibitors can exert anti-tumor efficiency in tumors with...
Enhancing recurrence detection in stage III colorectal cancer patients through molecular residual disease test-guided surveillance: A modeling study.
e15600 Background: Colorectal cancer (CRC) is a prevalent solid tumor cancer. Patients remain at risk of recurrence despite curative-intent treatment. Ear...
IsoPSA in prostate cancer: A systematic review of diagnostic, prognostic and economic implications.
e17166 Background: Prostate cancer (PCa) is the most commonly diagnosed cancer in men and 2nd leading cause of cancer-related deaths. Traditional Prostate...
Efficacy and safety of bevacizumab in combination with radiotherapy and temozolomide in patients with glioblastoma: A meta-analysis and meta-regression of randomized controlled trials.
2057 Background: Glioblastoma (GBM), the most common primary brain tumor in adults, has a poor prognosis despite standard treatment. This meta-analysis ev...
Clinicogenomic features of non-small cell lung cancer patients with <i>BRAF</i> non-V600mutations.
e20519 Background: BRAF non-V600 alterations are uncommon in non-small cell lung cancer (NSCLC). Little is known about the clinical, genomic c...
Decoding oncology terminology: Using large language models for patient education.
10600 Background: Large language models (LLMs), such as OpenAI's ChatGPT-4, are designed to process natural language and generate responses to text-based...
Pembrolizumab monotherapy for melanoma or non-small cell lung cancer in India: Results of the phase IV keynote-593 study.
e21518 Background: The PD-1 inhibitor pembrolizumab has been shown to provide a significant overall survival (OS) benefit with manageable safety in global...
Comprehensive germline sequencing and MLPA analysis in breast cancer patients: 4 years of experience from an Indian cancer institute.
e12542 Background: This study captures the clinical data and prevalence of the various germline mutations across breast cancer patients in India. It provi...
AREN1721, a randomized phase 2 trial of axitinib+nivolumab combination therapy vs. single agent nivolumab for the treatment of TFE/translocation renal cell carcinoma (tRCC) across all age groups, an NCI National Clinical Trials Network (NCTN) phase 2 study.
4521 Background: tRCC accounts for approximately 50% of pediatric RCC and 1-5% of RCC cases overall. tRCC, driven by TFE3 or...
Disparities in glioblastoma care: Insights from a nationwide survey.
11112 Background: Glioblastoma (GBM) care requires specialized, multidisciplinary management, often creating barriers to healthcare delivery and dispariti...
Decision analysis of PD-1 inhibitor combined with chemotherapy in neoadjuvant therapy of resectable locally advanced head and neck squamous cell carcinoma (LA HNSCC).
6074 Background: Neoadjuvant therapy (NAT) with PD-1 inhibitors plus chemotherapy has been shown to have a high pathological response rate in LA HNSCC, bu...
Intraoperative radiation therapy versus partial breast irradiation for early-stage breast cancer: A global, propensity-matched retrospective cohort study.
e12530 Background: Intraoperative radiation therapy (IORT) and partial breast irradiation (PBI) are two modalities of radiation used in the treatment of b...
Outcomes by baseline tumor burden using the 6-and-12 score in EMERALD-1: A phase 3 study of durvalumab (D) ± bevacizumab (B) with transarterial chemoembolization (TACE) in embolization-eligible unresectable hepatocellular carcinoma (uHCC).
4083 Background: In EMERALD-1 (NCT03778957), D + B + TACE significantly improved progression-free survival (PFS) vs TACE in participants (pts) with emboli...
Independent validation of a 16-protein test to assess malignant potential of small uveal melanocytic tumors.
9590 Background: Uveal melanocytic tumors of indeterminate malignant potential (UMTIMP) are usually managed by a “watch and wait” approach before the deci...