Journal of Clinical Oncology
Articles in this Issue
Adverse effects of immune checkpoint inhibitors in advanced endometrial cancer: A systematic review and meta-analysis.
5610 Background: Immune checkpoint inhibitors (ICIs) in combination with chemotherapy have become a standard first-line treatment for advanced endometrial...
Racial disparities in incidence and mortality among AYA patients with lung adenocarcinoma and squamous cell carcinoma in the US: A SEER database analysis.
e13744 Background: Despite a steady increase in the incidence of adolescent and young adult (AYA) lung cancer in the US, racial disparities involving lung...
Phase II trial of serplulimab combined with gemcitabine plus nab-paclitaxel (GnP) and SBRT for metastatic pancreatic cancer as the first-line treatment.
4160 Background: The addition of anti-PD-1 monoclonal antibody (mAb) to gemcitabine and nab-paclitaxel (GnP) presented limited improvement in objective re...
Disparities in receipt of palliative treatments among disaggregated Hispanic populations with breast, lung, and prostate cancer in the United States.
12029 Background: Despite palliative interventions’ ability to improve the quality of life and possibly improve overall survival, significant inequalities...
Effect of 4-1BBL-OX40L fusion protein on the anti-tumor activity of CAR-T cells in solid tumors.
e14535 Background: Chimeric antigen receptor T (CAR-T) cell therapy has shown clinical success in hematologic malignancies but faces challenges in solid t...
Community oncologists' and patients' perspectives on the post-CAR-T care transition: A convergent mixed-methods study.
e23134 Background: Chimeric antigen receptor T-cell (CAR-T) therapy is administered at accredited centers, with (w/) patients (pts) usually transitioning...
Mesenchymal stromal cells for the prophylaxis of graft-versus-host disease after hematopoietic stem cell transplantation: A meta-analysis of randomized controlled trials.
e18549 Background: Mesenchymal stromal cells (MSCs) have emerged as a potential alternative therapeutic strategy for the prophylaxis of graft-versus-host...
The influence of MRI scan position using a novel head and neck immobilization device on radical radiotherapy for nasopharyngeal carcinoma.
e18030 Background: To investigate the influence of MRI scan position on the registration accuracy, gross tumor volume (GTV) delineation, and radiotherapy...
Implementing the ASCO PGA in a remote Australian setting.
e13853 Background: Hamilton is a remote Australian town of 10,000 residents. With limited access to visiting oncologists, it has become apparent that inte...
RHEA-1: First-in-human (FIH) study of AZD9793, a first-in-class CD8-guided T cell-engager (TCE) for glypican-3-positive (GPC3+) advanced or metastatic hepatocellular carcinoma (HCC).
TPS4215 Background: GPC3 is an oncofetal protein expressed in 70–80% of HCC and is associated with poor prognosis. Preliminary clinical research on GPC3-s...
A technology-enabled clinical trial program’s impact on patient screening and trial enrollment in 2024.
1506 Background: Typical workflows for clinical trial start-up and screening are time- and resource-intensive. The Tempus AI TIME program offers a novel c...
Multigene NGS assay for biomarker identification in 621 colorectal cancer cases.
e15168 Background: Colorectal cancer (CRC), a major cause of cancer-related mortality, is driven by diverse genetic and molecular alterations. Advances in...
Clinical value of carbon nanoparticle staining in identifying metastatic lymph nodes in colorectal cancer surgery.
e15564 Background: Carbon nanoparticles (CNPs) are increasingly used to trace lymph nodes (LNs) in colorectal cancer (CRC) surgery. However, the relations...
AI-based predictive tool for detection of ctDNA in pancreatic adenocarcinoma using nationwide comprehensive genomic profiling data.
4163 Background: Comprehensive genomic profiling (CGP) has become a cornerstone of precision oncology, with liquid biopsy expanding its applicability. How...
Comprehensive longitudinal immune cell monitoring in patients with extensive-stage small-cell lung cancer patients treated with chemo-immunotherapy to predict early relapse.
8096 Background: Small cell lung cancer (SCLC) is characterized by rapid growth, and although initial chemo-immunotherapy achieves high response rates, re...
Multiomic profiling of LRRC15 in triple negative breast cancer (TNBC).
1098 Background: Leucine-rich repeat-containing protein 15 ( LRRC15) has emerged as a potential biomarker and therapeutic target f...
Integration of next-generation RNA sequencing-based MammaPrint and BluePrint analysis in clinical decision making: Performance evaluation in the first 1095 cases.
e12523 Background: Currently, multigene signatures (MGS) such as MammaPrint and BluePrint (MP/BP) have become a cornerstone for selecting breast cancer pa...
Caregiver distress: Caring for those who care for our patients.
11115 Background: Gynecologic cancers cause high physical and psychosocial strain, worsened by unmet social determinants of health (SDOH) in cancer care....
Impact of anti-EGFR and anti-VEGF antibodies on survival in BRAF <sup>V600E</sup> mutated metastatic colorectal cancer: A pooled analysis of eight clinical trials performed in the first-line treatment of mCRC (German AIO Study Group).
3543 Background: BRAF V600E mutation in metastatic colorectal cancer (mCRC) is associated with poor prognosis. Registrational appr...
Association of tumor extracellular matrix density with recurrence in invasive lobular carcinoma.
e15162 Background: Invasive lobular carcinoma (ILC) is associated with a unique pattern of dissemination and higher risk of late relapse ( > 10 years)...
Risk of intracranial hemorrhage with DOACs vs LMWH in patients with cancer-associated thrombosis and brain metastases.
2034 Background: Intracranial hemorrhage (ICH) is a major and often devastating complication in patients with brain metastases requiring therapeutic antic...
Real-world outcomes of cytarabine consolidation in older patients with acute myeloid leukemia.
e18535 Background: Acute myeloid leukemia (AML) predominantly affects elderly patients. Standard of care treatment includes induction chemotherapy, follow...
Monotherapy of envafolimab in patients with high tumor mutational burden advanced solid tumors: Results from a phase II clinical trial.
2595 Background: Tumor mutational burden (TMB) has emerged as a predictive biomarker of immune checkpoint blockade response in cancers. Envafolimab, a hum...
Phase 3 randomized trial (KEYNOTE-630) of adjuvant pembrolizumab (pembro) versus placebo (pbo) for high-risk locally advanced cutaneous squamous cell carcinoma (LA cSCC) following surgery and radiation (RT).
6000 Background: Patients with high-risk LA cSCC are standardly treated with surgical resection followed by postoperative RT. Up to 30% of pts experience...
Clinical outcomes and molecular characteristics of patients with metastatic pancreatic ductal adenocarcinoma according to involved metastatic sites.
4179 Background: It is well documented that Pancreatic ductal adenocarcinoma (PDAC) metastasize to the liver had worse outcome than to the lung, but the m...