Journal of Clinical Oncology
Articles in this Issue
ACR246, a first in next-generation 5T4-ADC, as a potential choice of treating 5T4-positive solid tumors.
e15110 Background: 5T4 oncofetal antigen shows limited expression in normal adult tissues but highly expressed by many dif...
Association of deep learning CT response assessment and interpretable components with overall survival in advanced NSCLC: Validation in a trial of sasanlimab and a real-world dataset.
1559 Background: Identifying advanced non–small cell lung cancer (aNSCLC) patients who derive long-term benefit from immune checkpoint inhibitors (ICIs) r...
The prognostic and predictive role of HER2 amplification/overexpression and <i>HER2</i> mutations in metastatic colorectal cancer treated with first-line chemotherapy plus bevacizumab/anti-EGFRs: An individual patient data pooled analysis of eight randomized trials.
3537 Background: HER2 amplification/overxpression (HER2-pos) is detected in the 5% of RAS/BRAF wild-type (wt) metastatic colorecta...
Efficacy and safety of post-mastectomy radiation therapy for patients with breast cancer after breast reconstruction: A retrospective multicenter cohort study (Reborn-03).
579 Background: A cornerstone of multidisciplinary treatment for breast cancer, breast reconstruction has recently been extended to high-risk patients wit...
The efficacy of atezolizumab plus bevacizumab for advanced hepatocellular carcinoma in relation to tumor-infiltrating lymphocytes: Histological assessment of CD8+ T cell spatial features as predictive biomarkers.
4103 Background: The combination of atezolizumab and bevacizumab (Atez/Bev) has improved prognosis in advanced hepatocellular carcinoma (HCC), though its...
Pharmacologic and pharmacometric studies of factors affecting the pharmacokinetics and pharmacodynamics of antibody drug conjugate anetumab ravtansine in patients with solid tumors.
e15024 Background: Anetumab ravtansine (AR) is an antibody-drug conjugate (ADC) containing the microtubule inhibitor DM4. ADC drugs have high interpatient...
Evaluation of p53 protein expression in endometrial carcinoma using immunohistochemistry: A study from Vietnam.
e17614 Background: The International Federation of Gynecology and Obstetrics (FIGO) 2023 recommends integrating molecular subtype evaluation into endometr...
From text to insight: Methods for validation of NLP-extracted real-world oncology data using a human-in-the-loop electronic review tool.
e23291 Background: Natural Language Processing (NLP) for extraction of oncology-specific data-phenotypes from free-text in electronic medical records (EMR...
Struma ovarii: An NCDB retrospective study of demographic and socioeconomic factors.
e17590 Background: Struma ovarii malignant cancer (SOMC) is an extremely rare ovarian teratoma originating from aberrant thyroid tissue that can mimic thy...
Induction cadonilimab combined with chemotherapy followed by chemoradiotherapy for locally advanced cervical cancer: A multicenter, single-arm, phase II trial.
5530 Background: Short-course weekly induction chemotherapy followed by chemoradiotherapy (CCRT) improves survival for locally advanced cervical cancer (L...
Phase 1/2 study of nivolumab and ipilimumab combined with gemcitabine, nab-paclitaxel, and adaptive stereotactic body radiotherapy in bordeline resectable, locally advanced or metastatic pancreatic cancer (LAPTOP).
4168 Background: This phase 1/2 study (NCT04247165) evaluated the safety and efficacy of combining nivolumab, ipilimumab, gemcitabine, nab-paclitaxel, and...
Comparative analysis of health disparities in prostate cancer patients with and without venous thromboembolism, and with and without anticoagulation therapy.
e17162 Background: Venous thromboembolism (VTE) in cancer is a commonly observed clinical complication. The risk of VTE is high in prostate cancer when co...
Perceptions, attitudes, and concerns about artificial intelligence applications in patients with cancer.
e13626 Background: The use of artificial intelligence (AI) in oncology has increased rapidly, spanning applications such as pathology, radiology, diagnost...
Cardiovascular risk factor control and risk of future cardiovascular events in survivors of childhood cancer: A report from the St. Jude Lifetime cohort.
10065 Background: Modifiable cardiovascular risk factors (CVRFs; hypertension, diabetes, dyslipidemia) contribute to the excess health-related death in lo...
V-RULES: Real-world effectiveness and safety of CPX-351 in patients with secondary acute myeloid leukemia (AML).
6520 Background: CPX-351 was approved for newly diagnosed (ND) therapy-related AML (t-AML) or AML with myelodysplasia-related changes (AML-MRC) following...
A simplified scoring system to predict in-hospital mortality of leukapheresis in patients with leukemia.
6575 Background: The 2019 consensus guidelines from the American Society for Apheresis recommend leukapheresis as a category II recommendation (acceptable...
Menopausal hormone therapy after a diagnosis of breast cancer in women with a <i>BRCA</i> pathogenic variant and risk of death.
10506 Background: Use of menopausal hormone therapy (MHT) is contraindicated for women with a personal history of breast cancer. This topic is of importan...
Regional trends in disability adjusted life years (DALYs) and mortality of pancreatic cancer among older adults (70+): A global burden of disease study (1990–2021).
11153 Background: Pancreatic cancer is a major health challenge, particularly for older adults, with significant regional disparities in its burden over t...
Efficacy of local therapy in Chinese patients with BCLC stage C hepatocellular carcinoma (HCC): A retrospective cohort study of 370 patients over six years.
e16228 Background: Even though systemic therapy has been recommended as the standard of care for advanced HCC at Barcelona Clinic Liver Cancer (BCLC) stag...
Characterizing the prevalence and prognostic significance of MTAP loss in endemic nasopharyngeal cancer using immunohistochemistry (IHC) versus fluorescent in situ hybridization (FISH).
6052 Background: Methylthioadenosine phosphorylase (MTAP) loss has been associated with poor outcomes in various cancers, including nasopharyngeal carcino...
A real-world study on epidemiology, biomarker test results, clinical characteristics, and treatment patterns of unresectable locally advanced or metastatic gastric and gastroesophageal junction adenocarcinoma in China.
e16013 Background: Gastric cancer is the fifth most common cancer and third leading cause of cancer-related death in China, with about 90% classified as a...
Irradiated tumor volume as a predictor of local recurrence and radionecrosis in lung cancer with brain metastases treated with stereotactic radiosurgery.
2024 Background: Stereotactic radiosurgery (SRS) is a standard local treatment for brain metastases (BM), but it may result in local recurrence (LR) or ra...
First-line durvalumab with arterial chemotherapy in major portal invaded hepatocellular carcinoma: The phase 2 DurHope study with biomolecular analyses.
e16232 Background: Hepatocellular carcinoma (HCC) patients with Vp4 portal vein tumor thrombus (PVTT) have a poor prognosis and are underrepresented in gl...
Impact of demographic and socioeconomic factors on survival outcomes in patients with Waldenstrom macroglobulinemia: A SEER database analysis from 2000-2021.
e19046 Background: Waldenstrom Macroglobulinemia (WM) is a rare, indolent B-cell malignancy characterized by the overproduction of IgM monoclonal proteins...
An exploratory study of neoadjuvant tislelizumab combined with TP regimen for the comprehensive treatment of resectable locally advanced oral squamous cell carcinoma.
e18034 Background: The landscape of neoadjuvant immunotherapy for resectable locally advanced head and neck squamous cell carcinoma has improved significa...