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Multimodal MRI-based quantification of tumoral spatial heterogeneity for preoperative upgrade prediction of ductal carcinoma in situ
Abstract This retrospective study aimed to develop a multimodal habitat-based model integrating clinicopathological factors, radiomics features, and intratumoral heterogeneity (ITH) score for predicting upstaging in patients with ductal carcinoma in situ (DCIS). A total of 389 DCIS patients from two institutions were included. Lesions were segmented on DCE-MRI, DWI, and ADC images with peritumoral expansion, and intratumoral and peritumoral habitats were identified using Gaussian mixture model (GMM) clustering. Radiomics features were extracted from each habitat, and ITH scores were calculated. Independent predictors of upstaging were identified using multivariate logistic regression, and multiple models were constructed and evaluated. Age, nuclear grade, palpable mass, and DCE-ITH score were independent risk factors for DCIS upstaging. Habitat-based models derived from intratumoral and peritumoral regions demonstrated good predictive performance, while the combined model integrating habitat features, ITH score, and clinicopathological variables achieved the best performance, with AUCs of 0.945 and 0.869 in the training and test cohorts, respectively. This multimodal combined model may facilitate individualized preoperative risk assessment and support clinical decision-making in DCIS patients.
Upcoming FDA approval decisions in Q3 2026
Liquid biopsy to inform adjuvant decisions during neoadjuvant chemotherapy — a full-circle moment for nasopharyngeal cancer
Titin cleavage in living cardiomyocytes induces sarcomere disassembly but does not trigger cell proliferation
Study on mechanical properties and energy evolution laws of layered sandy slate
Antiviral peptide nabs FDA approval for hepatitis delta virus infection
Synergistic integration of regional and systemic therapies in uveal melanoma
Parasite-specific essential bromodomain protein TgBDP4 is a key epigenetic reader and a potential drug target for the parasite Toxoplasma gondii
Correspondence on “Fortification of FeS Clusters Reshapes Anaerobic CO Dehydrogenase Into an Air‐Viable Enzyme Through Multilayered Sealing of O <sub>2</sub> Tunnels”
ABSTRACT In their recent communication in Angewandte Chemie ( 10.1002/anie.202508565 ), Suk Min Kim and coworkers have described the effect of modifying the gas channels of the CO dehydrogenase II from Carboxydothermus hydrogenoformans , an enzyme that oxidizes reversibly CO into CO 2 . Their goal was to use mutagenesis to slow down the arrival of O 2 at the active site. They reported a large increase in the resistance against oxygen, one of the major barriers to the application of this extremely fast and efficient enzyme in biotechnological devices, with an increase in the IC 50 of more than two orders of magnitudes for some variants, with only a minor impact on the affinity of the enzyme for CO. We have produced the same variants, and characterized them in depth using Protein Film Electrochemistry. We used an approach that has proven very useful to learn and understand about the reactivity of CO dehydrogenases (and other redox enzymes like hydrogenases) with O 2 . We found that, contrary to the claims by Kim and coworkers, the A559W and the A559W/V610H mutants are not more resistant than the wild type against oxygen.
Superclonal expansion and barley yellow dwarf virus transmission failure in invasive Metopolophium festucae cerealium
Abstract Biological invasions can influence ecosystems, yet the evolutionary trajectories and disease dynamics of clonal expansion remain poorly understood. Since its 2011 detection, Metopolophium festucae cerealium (Stroyan), a subspecies of the cereal grass aphid endemic to Europe, has expanded across small grain growing regions of the western U.S. Our field surveys further indicate continued range expansion into previously unreported areas. Here, we integrate population genomics with virus transmission assays to evaluate its invasion structure and potential role in barley yellow dwarf virus (BYDV) transmission. Genome-wide SNP analysis of 262 individuals from six states reveals high genetic homogeneity, supporting a single introduction event and subsequent superclonal expansion. Although M. f. cerealium acquires BYDV at rates comparable to native Rhopalosiphum padi and maintains similar viral titers, it fails to transmit the virus. The primary agroecological risk posed by this invasion is through direct feeding injury, underscoring the need for continued monitoring and refined pest management strategies.