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Late-Stage Carboranylation of Nucleos(t)ides Enabled by Minisci and Pd-Catalyzed B–N Cross-Coupling Reactions: Toward the Synthesis of Carboranyl-Modified Oligonucleotides
Bio-efficacy of Syzygium aromaticum bud extract as eco-friendly green acaricide for controlling Hyalomma dromedarii
Abstract The most common hard tick in Egypt is Hyalomma dromedarii as a one of the most dangerous ectoparasites. The current study aims to detect the chemical composition of Syzygium aromaticum bud ethanolic extract using GC-MS and some phytochemical analysis in addition to investigating its acaricidal activity on H . dromedarii engorged females through biological and biochemical studies. The GC-MS revealed the presence of eugenol, eugenol acetate and D-(-)-fructofuranose as the most active compounds, and it appeared to be rich in alkaloids, flavonoids, phenolic compounds, tannins and terpenoids. At high concentration, the extract caused mortality to reach 100% after 35 days of treatment in engorged females, with LC 50 reached 100.22 and 0.83 mg/mL after the 3rd and 5th week (half and end of examined period) following treatment, respectively. The blood digestion was affected by significantly decreasing in their body weights. Furthermore, the extract showed a decrease in their oviposition, hatchability, and fertility. The extract at 100 mg/mL caused a reduction in ovary total protein content with disappearance of some protein bands using SDS-PAGE, compared with the control group. Overall, the current study revealed the effectiveness of S . aromaticum extract as a bio-acaricide for controlling H . dromedarii and it recommended numerous additional field studies to assess its effectiveness under different conditions.
Incretin-based multi-agonist reverses obesity and diabetes
Global identification of Chromobacterium violaceum T6SS effectors reveals an Rhs antibacterial toxin featuring FIX and ADP-ribosyltransferase domains
Portable, real-time 3D ultrasound for operator-independent breast imaging
Atomic-Scale Selective C–H Halogenation Driven by Tip Electric Field in Water
A unified post-quantum zero-trust architecture with AI-driven orchestration for secure healthcare fog networks
FDA approves first-in-class hypertension drug
A high-sensitivity strategy to screen NAD(P)H-dependent reductase activity by coupled enzyme cascade
Adjunctive ibuprofen in pre-extensively drug-resistant and extensively drug-resistant tuberculosis: a phase IIA open-label pilot clinical trial
Abstract Drug-resistant tuberculosis remains a major global health challenge, and excessive inflammation may contribute to tissue damage and poor outcomes. We conducted a phase IIA prospective open-label pilot trial (ClinicalTrials.gov: NCT02781909) evaluating adjunctive ibuprofen in adults with pulmonary pre-extensively drug-resistant (pre-XDR) or extensively drug-resistant (XDR) tuberculosis in Georgia. Twenty-eight participants received individualized background anti-tuberculosis regimens alone ( n = 14) or with ibuprofen 400 mg daily for 2 months ( n = 14) and were followed for 6 months. The primary efficacy outcome was the proportion of participants showing clinical and/or microbiological benefit, assessed by sputum culture conversion, radiological evolution, and WHO-defined treatment outcomes. Secondary outcomes were safety and tolerability, health-related quality of life, and inflammatory and transcriptomic responses. Adding adjunctive ibuprofen did not improve month-2 sputum culture negativity, time to stable culture conversion, radiological evolution, or final treatment outcomes. Safety and tolerability were similar between groups. Adverse events were recorded and reviewed, but not formally graded for severity. Ibuprofen treatment was associated with numerically greater reductions in several blood-based inflammatory measures and in transcriptomic signature scores associated with poor tuberculosis outcomes. These findings are exploratory and do not demonstrate clinical benefit but indicate biological activity and support evaluation of anti-inflammatory host-directed therapies in larger controlled trials.
Multidimensional Band-Structure Engineering in Chalcogen-Substituted Covalent Organic Frameworks Through Electrophilicity, Lattice Strain, and Defect Regulation
Artificial intelligence optimization model for public safety in smart cities based on multi-source data collaboration in the internet of things
Functional characterization of UHRF1 variants in facilitating DNA methylation
Publisher Correction: Divergent multifunctional P450s-empowered biosynthesis of bioactive tripterifordin and cryptic atiserenoids in Aconitum implies convergent evolution
Initiating Photocontrolled Atom Transfer Radical Polymerization from a Redox-Activated Functional Group
Recognition of specific amino acids in migratory rivers and daily rhythmic behavior of naked carp (Gymnocypris przewalskii)
Abstract Gymnocypris przewalskii is an endemic migratory fish in the high-altitude, saline-alkaline Lake Qinghai. This study investigated whether L-serine (Ser) acts as a chemical cue guiding its migration. Water analysis revealed significantly higher concentrations of Ser in migratory rivers than in the lake, where phenylalanine (Phe) dominated. In behavioral experiments, G. przewalskii exhibited a significant preference for Ser-enriched water during the daytime (10:00, 15:00, 18:00), spending 63% to 74% of the time in the Ser chamber, while their preference for Ser diminished at night (21:00), where the time spent in the Ser chamber was only 34%. Additionally, G. przewalskii showed significantly lower instantaneous swimming speeds and reduced turning frequencies in the Ser-enriched water compared to the control group, indicating a more stable behavioral pattern. Furthermore, continuous monitoring revealed that the migration frequency of G. przewalskii during the daytime was significantly higher than at night, suggesting that light conditions may interact with chemical cues to regulate their migratory behavior. This study provides evidence of significant differences in the amino acid composition between the lake water and the migratory rivers of Lake Qinghai, as well as G. przewalskii ’s preference for Ser in the migratory rivers. It also highlights the distinct diel rhythmicity in their migratory behavior, offering valuable scientific insights for understanding the adaptive mechanisms of saline-alkaline fish species. These findings also have important implications for the conservation of the Lake Qinghai ecosystem.