Hierarchical sensory processing in zebrafish thalamocortical-like circuits
Abstract
Thalamocortical projections shape the functional regionalization and parallel sensory computations across the mammalian cortex. However, the principles of thalamocortical computations in non-mammalian vertebrates remain underexplored. Here we investigated how the zebrafish pallium, a homolog of the vertebrate cortex, receives and processes sensory information, and how its architecture compares to thalamocortical circuits in other vertebrates. We revealed that the preglomerular complex (PG), a thalamocortical-like pathway, is the primary source of visual and vibrational information to the zebrafish pallium. PG and its pallial projections exhibit sensory-specific and topographically organized responses. In contrast, pallial neurons display topographically organized hierarchies, ranging from sensory-specific to multimodal and coincidence-detecting nonlinear responses. Our results suggest that hierarchies of sensory transformations across topographically organized thalamocortical-like circuits reflect a convergent principle across vertebrates.
Article Details
Journal Info
Science
American Association for the Advancement of Science
Authors (9)
Anh-Tuan Trinh
Kavli Institute for Systems Neuroscience and Centre for Algorithms in the Cortex, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Anna Maria Ostenrath
Kavli Institute for Systems Neuroscience and Centre for Algorithms in the Cortex, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Ignacio del Castillo-Berges
Kavli Institute for Systems Neuroscience and Centre for Algorithms in the Cortex, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Fanchon Cachin
Kavli Institute for Systems Neuroscience and Centre for Algorithms in the Cortex, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Mina Koç
Graduate School of Health Sciences, Koç University, Istanbul, Turkey.
Susanne Kraus
Kavli Institute for Systems Neuroscience and Centre for Algorithms in the Cortex, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Bram Serneels
Kavli Institute for Systems Neuroscience and Centre for Algorithms in the Cortex, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Koichi Kawakami
Laboratory of Molecular and Developmental Biology, National Institute of Genetics, Mishima, Japan.
Emre Yaksi
Kavli Institute for Systems Neuroscience and Centre for Algorithms in the Cortex, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.