PLoS ONE
Articles in this Issue
Multifaceted barriers associated with clinical breast examination in sub-Saharan Africa: A multilevel analytical approach
Objectives Clinical breast examination (CBE) open the pathway to early detection and diagnosis of breast cancer. This study examined barriers to CBE uptake in seven sub-Saharan African (SSA) countries...
Pharmacophore modeling and QSAR analysis of anti-HBV flavonols
Due to its global burden, Targeting Hepatitis B virus (HBV) infection in humans is crucial. Herbal medicine has long been significant, with flavonoids demonstrating promising results. Hence, the prese...
Differential insulin response characteristics of graphene oxide–gold nanoparticle composites under varied synthesis conditions
The structural alterations in the constituent materials of nanocomposites such as graphene nanocomposites typically induce changes in their properties including mechanical, electrical, and optical pro...
Comparison of a non-invasive point-of-care measurement of anemia to conventionally used HemoCue devices in Gambella refugee camp, Ethiopia, 2022
Annual surveys of refugees in Gambella, Ethiopia suggest that anemia is a persistent public health problem among non-pregnant women of reproductive age (NP-WRA, 15–49 years). Measurement of anemia in...
Optimizing costs and sustainability for gamma knife radiosurgery: A cost and breakeven analysis at India’s largest neurosurgery centre
Background Establishing and maintaining gamma knife facility incurs significant costs, mandating healthcare institutions to meticulously assess financial implications for sustainab...
Paediatric sedation with intranasal dexmedetomidine: Protocol for a systematic review and meta-analysis
Introduction Sedation ensures a child remains motionless during a procedure and decreases anxiety. Several pharmacologic regimes exist for paediatric sedation. However, often, intravenous cannulation...
Coping strategies and changes in type D personality were associated with depressive tendency at 9 months after percutaneous coronary intervention
Type D personality, characterized by negative affectivity and social inhibition, has been associated with both the psychophysiology of coronary artery disease (CAD) and depressive disorders. However,...
Induction of stigma-like structures in saffron (Crocus sativus L.): Exploring factors and metabolite analysis
Saffron (Crocus sativus L.) has held significant cultural and medicinal value since the Greek-Minoan civilization. As a triploid spice with vegetative propagation from the Iridaceae family, the three-...
Iron deficiency and fatigue in inflammatory bowel disease: A systematic review
Background It is unclear what impact iron deficiency has on fatigue in people with inflammatory bowel disease (IBD). This systematic review examined the evidence of whether iron deficiency, with or wi...
Sex-specific associations of serum testosterone with gray matter volume and cerebral blood flow in midlife individuals at risk for Alzheimer’s disease
Testosterone, an essential sex steroid hormone, influences brain health by impacting neurophysiology and neuropathology throughout the lifespan in both genders. However, human research in this area is...
Business environment and its impact on high-quality economic development: A configurational analysis of enhancement pathways
The nexus between the business environment and high-quality economic development is pivotal for fostering sustainable growth. This study delves into their interrelationship, recognizing its profound p...
The impact of tuberculosis-induced hyperglycemia on pulmonary microbiota and airway mucus secretion in individuals not previously diabetic: A systematic review and meta-analysis protocol
The lung environment harbours a community of microbes that play a significant role in health and disease, including innate protection against pathogenic microorganisms. Infection with Mycobacterium tu...
Feasibility and resource utilization of nurse-administered subcutaneous immunoglobulin therapy in antibody deficiency: A cross-sectional study
Primary and secondary antibody deficiencies (PAD and SAD) are amongst the most prevalent immunodeficiency syndromes, often necessitating long-term immune globulin replacement therapy (IRT). Both intra...
Comparing the technical and individual possession statistics of academy players across different age groups in match-play
Background Youth soccer players in the UK transition into the professional game at 16 years of age. Understanding the differences between youth and professional standards can help coaches and clubs to...
The current landscape of personalised preventive approaches for non-communicable diseases: A scoping review
Introduction Personalised prevention offers a promising tool to reduce the impact of non-communicable diseases, which represent a growing health burden worldwide. However, to support the adoption of t...
Associations of RANKL levels and polymorphisms with rheumatoid arthritis: A meta-analysis
Objectives This study examined the correlation between circulating receptor activator for nuclear factor-κB ligand (RANKL) levels and rheumatoid arthritis (RA), and investigated the association betwee...
An analytical study of active earth pressure in cohesive soil considering interlayer shear stress
The impact of interlayer shear stress on the distribution of earth pressure in cohesive soil is notable, but currently, there lacks a comprehensive theory that integrates this factor in the calculatio...
Teacher voices matter: The role of teacher autonomy in enhancing job satisfaction and mitigating burnout
This study aims to explore variables associated with teacher burnout at the end of the 2021–2022 school year and shed light on teachers’ mental health issues related to psychological factors. We colle...
Extracting speech spectrogram of speech signal based on generalized S-transform
In speech signal processing, time-frequency analysis is commonly employed to extract the spectrogram of speech signals. While many algorithms exist to achieve this with high-quality results, they ofte...
Mesenchymal stem cell-derived exosome and liposome hybrids as transfection nanocarriers of Cas9-GFP plasmid to HEK293T cells
Exosomes are natural membrane-enclosed nanovesicles (30–150 nm) involved in cell-cell communication. Recently, they have garnered considerable interest as nanocarriers for the controlled transfer of t...
Cost efficiency of commercial banks in Ethiopia: Does financial technology matter?
This study aims to assess the effects of financial technology on the cost efficiency of commercial banks in Ethiopia. Secondary panel data were collected from the audited annual reports of seventeen c...
Forecasting the use of chiropractic services within the Veterans Health Administration
Objective To model future use of chiropractic services and predict clinical resource needs within the Veterans Health Administration (VA) over the next 5 years. Methods A serial cross-sectional anal...
Capacity-building interventions for health extension workers in Ethiopia: A scoping review
Introduction Capacity-building interventions for health extension workers (HEWs) are key to providing quality health services to the community. Since Ethiopia’s Health Extension Program was establishe...
Risky behavior in virtual reality: The roles of personality, environment, and physiology
Virtual reality (VR) provides a unique opportunity to simulate various environments, enabling the observation of human behavior in a manner that closely resembles real-world scenarios. This study aime...
Increased resting heart rate indicates high-workload hearts with augmented aortic hydraulic power in hypertensive pigs
Clarifying the inceptive pathophysiology of hypertensive heart disease helps to impede the disease progression. Through coarctation of the infrarenal abdominal aorta (AA), we induced hypertension in m...