PLoS ONE
Articles in this Issue
New bounded unit Weibull model: Applications with quantile regression
In practical scenarios, data measurements like ratios and proportions often fall within the 0 to 1 range, posing unique modeling challenges. While beta and Kumaraswamy distributions are widely used, a...
Disruption of adaptive immunity does not attenuate disease in the Ndufs4(-/-) model of Leigh syndrome
Leigh syndrome (LS) is the most common pediatric presentation of genetic mitochondrial disease and characterized by neurological and metabolic abnormalities. The hallmark of the disease is the presenc...
Chain mediating effect of self-esteem and resilience on the relationship between wellbeing literacy and subjective well-being among college students
Based on the framework of psychological capital theory from the perspective of positive psychology, this study explores the influence mechanism of wellbeing literacy on the subjective well-being of co...
Gene expression study in the siRNA based aniridia cell model and in primary aniridia limbal epithelial cells following duloxetine and ritanserin treatment
Progressive aniridia associated keratopathy is worsening visual acuity of congenital aniridia subjects lifelong. Restoration of PAX6 expression in PAX6 haploinsufficient limbal epithelial cells could...
Influence of Messa di Voce speed on vocal stability of professionally trained singers
Introduction Messa di Voce (MdV) is a challenging task for singers, requiring an even modulation of sound pressure level (SPL) on a stable pitch. This study concentrates on the effects of fast or slow...
Predictors of neuropsychiatric manifestations in pediatric patients with lupus
Early detection of neuropsychiatric systemic lupus erythematosus (NPSLE) in children remains challenging in clinical settings. This study aims to describe the autoantibodies, organ disorders, the SLED...
Community density patterns estimated by species distribution modeling: The case study of an insect virus interaction
We studied the interaction between the invasive potato moth T. solanivora and its granulovirus PhopGV in the northern An...
The impact of the COVID-19 pandemic on vaccinations in United States primary care practices
Background The COVID-19 pandemic caused substantial burdens for patients and our healthcare delivery system. Many patients delayed seeking care for essential medical needs, and providers struggled to...
Impact of multiple consultations and switching in treatment-seeking in tuberculosis: Mathematical modelling and optimal control
Treatment-seeking behaviour significantly contributes to the worldwide tuberculosis (TB) burden, especially in Southeast Asia and African regions. At the onset of symptoms like coughing, fever, fatigu...
Correction: An integrated approach for advanced vehicle classification
Effect of different levels of Scutellaria baicalensis straw on slaughter performance and rumen microorganisms of rams
The shortage of forage supply has become an issue for the development of high-quality animal husbandry. Utilizing functional diets can mitigate forage shortages while enhancing animal performance and...
Sage extract and ascorbic acid derivative inhibit melanogenesis via downregulating keratinocyte-derived GM-CSF
Salvia officinalis (sage) extract has demonstrated potential as a functional ingredient for skin care application. However, its effect and mechanism in regulating skin pigmentation remain largely uncl...
TBKIN: Threshold-based explicit selection for enhanced cross-modal semantic alignments
Vision-language models aim to seamlessly integrate visual and linguistic information for multi-modal tasks, demanding precise semantic alignments between image-text pairs while minimizing the influenc...
Assessing mercury and lead pollution in the Ankobra estuary due to artisanal mining activities: Implications for water quality and aquatic life
Artisanal and small-scale gold mining, “Galamsey” as it is called in Ghana, within the Ankobra estuary has impacted the water quality, fish health and other aquatic organisms. This paper presents a st...
Characterization of the genomic landscape of canine oral osteosarcoma reveals similarities with appendicular osteosarcoma
Osteosarcoma (OS) is the most common bone tumor in both dogs and humans. It predominantly occurs in the appendicular skeleton, with about 25% of cases occurring within the axial skeleton. Progression...
Computational investigation unveils pathogenic LIG3 non-synonymous mutations and therapeutic targets in acute myeloid leukemia
Single nucleotide polymorphisms (SNPs) in DNA repair genes can impair protein structure and function, contributing to disease development, including cancer. Non-synonymous SNPs (nsSNPs) in the...
Before hands disappear: Effect of early warning visual feedback method for hand tracking failures in virtual reality
Virtual hand representation in Head-Mounted Displays (HMDs) offers immersive and intuitive interactions in Virtual Reality (VR). However, current hand tracking algorithms are prone to errors, which ca...
Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and urinary albumin-creatinine ratio (ACR) in US adults: NHANES 2005–2018
Purpose The ratio of non-high-density lipoprotein cholesterol (NHDL-C) to high-density lipoprotein cholesterol (HDL-C), referred to as NHHR, is an emerging lipid parameter. The relationship between NH...
The relationship between N-terminal pro-brain natriuretic and coronary artery lesions in Kawasaki disease: A meta-analysis
Background Regarding the value of N-terminal brain natriuretic peptide precursors in evaluating coronary artery lesions (CAL) in Kawasaki disease. Objective To conduct a meta-analysis of relevant li...
Correction: Assessing the potential of polygenic scores to strengthen medical risk prediction models of COVID-19
Acute effects of inspiratory muscle warm-up on muscle oxygenation, perceived exertion and prefrontal cortical activation
Objectives As rowing training loads intensify, the resulting high subjective exertion may force athletes to expand excessive neural impulses and cognitive resources. Given the finite nature of neural...
Moderating role of mindfulness and social support in the relationship between fertility pressure and fertility quality of life in Chinese infertile men
Men with infertility are susceptible to fertility pressure, thus affecting their fertility quality of life. To develop fertility-pressure resilience interventions, we investigated whether mindfulness...
The effects of hydrotherapy on athletic ability in children with cerebral palsy: A systematic review and meta-analysis
Background Cerebral palsy (CP) is a disability caused by brain malformations or injuries occurring from conception to infancy. Hydrotherapy is a popular treatment for children with cerebral palsy and...
Research on APT groups malware classification based on TCN-GAN
Advanced Persistent Threat (APT) malware attacks, characterized by their stealth, persistence, and high destructiveness, have become a critical focus in cybersecurity defense for large organizations....
Exploring the barriers and facilities migrants face in accessing COVID-19 vaccines in Malaysia: A qualitative study
Background Malaysia provided COVID-19 vaccines for all residents, regardless of citizenship status. However, the extent of vaccine accessibility for migrant populations remains unclear, given the comp...