PLoS ONE
Articles in this Issue
Immunosuppression variably impacts outcomes for patients hospitalized with COVID-19: A retrospective cohort study
Background Adults with immunosuppression are more likely to develop severe COVID-19 than adults without immunosuppression. Less is known about differences in outcomes for adults with immunosuppression...
Precision-cut tumor tissue slices, a novel tool to study the tumor microenvironment interactions with chimeric antigen receptor (CAR) T cells
Up until present day, chimeric antigen receptor (CAR)-T cell therapy has only been approved for hematological malignancies, as CAR-T cells do not show comparable efficacy in solid tumors. Therefore, u...
Changes in functional outcome after a first-time stroke: Data from a longitudinal study
Background Strokes are the major cause of disability. Functional recovery following an acute stroke is time-dependent and varies depending on several factors. This study aimed to investigate changes i...
Liver MRI proton density fat fraction inference from contrast enhanced CT images using deep learning: A proof-of-concept study
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common cause of chronic liver disease worldwide, affecting over 30% of the global general population. Its progressive natur...
Investigating university English as a foreign language instructors’ implementations in teaching integral listening with speaking
Employing integral instruction of listening and speaking, and understanding their roles is significant for effective language teaching, developing learners’ spoken and written proficiencies, and impro...
Effect of individualized PEEP on lung ultrasound score and optic nerve sheath diameter in elderly patients undergoing laparoscopic rectal cancer surgery: A randomized controlled trial
Objective Positive end-expiratory pressure (PEEP) is widely used during surgery, but its effects on lung and brain protection remain debated. This study aimed to evaluate the impact of individualized...
Augmented secretary bird optimization algorithm for wireless sensor network deployment and engineering problem
This study develops an enhanced Secretary Bird Optimization Algorithm (ASBOA) based on the original Secretary Bird Optimization Algorithm (SBOA), aiming to further improve the solution accuracy and co...
RETRACTED: LGD_Net: Capsule network with extreme learning machine for classification of lung diseases using CT scans
Lung diseases (LGDs) are related to an extensive range of lung disorders, including pneumonia (PNEUM), lung cancer (LC), tuberculosis (TB), and COVID-19 etc. The diagnosis of LGDs is performed by usin...
Correction: Recombinant cyclin B-Cdk1-Suc1 capable of multi-site mitotic phosphorylation in vitro
Emergency temporary standards and COVID-19 trends among Oregon farmworkers
Background During the COVID-19 pandemic, migrant and seasonal farmworkers were deemed essential due to their central roles in US agricultural operations. However, employer-provided housing and transpo...
Mental health concerns and needs of international students in higher education settings: A scoping review protocol
Introduction The transition to higher education is a significant milestone for many individuals; however, it also brings new stressors and challenges, particularly for international students adjusting...
Bioinformatics analysis to explore biomarkers and mechanisms of action associated with endoplasmic reticulum stress and ferroptosis in Parkinson’s disease
Objective It has been demonstrated that Parkinson’s disease (PD) is closely associated with endoplasmic reticulum stress (ERS) and ferroptosis. However, the specific mechanisms underlying these associ...
Predictors of elevated carotid intima-media thickness as a surrogate marker for cardiovascular disease in pediatric chronic kidney disease
Background Chronic kidney disease (CKD), especially in its late stages, carries significant morbidity and mortality, often due to cardiovascular problems. Mortality rates for children with CKD and car...
A cross-country analysis of feasible income equality using the sigmoid function and the Boltzmann distribution
This study uses the sigmoid function in combination with the Boltzmann distribution, originally developed by Park and Kim (2021), in order to calculate the optimal income distribution that represents...
In vitro study of probiotic Lactobacillus helveticus: Antibacterial effects on Porphyromonas gingivalis
Probiotics are gaining attention for their benefits as a supplement to improve oral health. This study aimed to evaluate the antibacterial effect of the probiotic Lactobacillus helveticus against Porp...
Gradual reputation dynamics evolve and sustain cooperation in indirect reciprocity
Humans have achieved widespread cooperation, largely sustained by mechanisms such as indirect reciprocity, which relies on reputation and social norms. People are highly motivated to maintain a good r...
Daraxonrasib, a pan-RAS inhibitor, selectively inhibits osteosarcomas with activated KRAS by halting AKT signaling and matrix metalloprotease activity
KRAS mutations, which induce proliferative signaling driving many human cancers, are detectable in a small subset of osteosarcoma patients. The recently developed pan-KRAS inhibitor daraxonrasib, also...
Correction: High mean corpuscular volume as a predictor of esophageal cancer: A cohort study based on the Japanese Shizuoka Kokuho Database
Malaria, urogenital schistosomiasis and co-infection and nutritional status of school children in Ondo state
Parasitic infections are a major cause of morbidity and mortality in Nigeria, with malaria and schistosomiasis having the highest burden. This study investigated the prevalence of malaria, urogenital...
Racial/Ethnic differences in emergency department triage assignment among visits for substance use
Background The opioid/substance use disorder (SUD) epidemic in the United States has become a public health crisis. Stigma by health care workers towards patients with SUD has been identified as a bar...
Preoperative assessment using a scoring system after neoadjuvant chemotherapy with docetaxel, cisplatin, and 5-fluorouracil for locally advanced esophageal cancer: Who can avoid surgery?
Neoadjuvant chemotherapy (NAC) with docetaxel, cisplatin, and 5-fluorouracil (DCF) is highly effective for advanced esophageal squamous cell carcinoma, and patients with a good response sometimes desi...
Oak-YOLO: A high-performance detection model for automated Oak seed defect identification
Oak seeds are highly susceptible to pest infestations due to their elevated starch content, which significantly impairs germination and subsequent growth. To address this challenge, we developed a hig...
Determinants of dental caries in deciduous teeth among Iranian school children: Evidence from a developing country
Background Understanding the social determinants of oral health is essential for addressing oral health disparities and facilitating the implementation of effective oral health policies. Therefore, th...
Some simulations of age-period-cohort analysis applying Bayesian regularization: Conditions for using random walk model
Age-period-cohort (APC) analysis, one of the fundamental time-series models, has an identification problem of the inability to separate linear components of the three effects. However, constraints to...
Prevalence and clinicopathological characteristics of breast cancer patients with brain metastases in Ghana: A single-center cross-sectional study
Breast cancer remains a leading cause of cancer-related mortality among women globally. While advances in early diagnosis and systemic therapies have improved survival, they have also increased the li...