PLoS ONE
Articles in this Issue
The impact of management compliance attention and board faultlines strength on ESG performance: Evidence from Chinese listed companies
Against the backdrop of global sustainable development goals and the rapid evolution of ESG practices in China, this study empirically examines how management compliance attention and board faultlines...
Uricase deficiency in rats results in a variety of metabolic disorders, addition to gouty nephropathy
Clinical evidence suggests that hyperuricemia is frequently associated with hyperglycemia (diabetes), hyperlipidemia, and hypertension. However, this relationship has not been fully verified in experi...
Ischemic duration determines extent of cardiac remodeling, and both early and delayed reperfusion prevent fatal cardiac rupture: Model comparison
High incidence of cardiac rupture in murine myocardial infarction (MI) model leads to a substantial loss before the study end-point. Selecting animal models with varying degrees of injury for differen...
Understanding the evolving treatment landscape of hidradenitis suppurativa: An analysis of All of Us
Background Hidradenitis suppurativa (HS) is a chronic skin condition with significant burden for affected patients. The development of new therapies in the last decade has brought hope for better pati...
Effects of different blood flow rates on filter and circuit life in non-anticoagulation CRRT: Protocol for a three-arm, single-blind randomized controlled trial (the Flow-CRRT Study)
Background Non-anticoagulation is a commonly used strategy in continuous renal replacement therapy (CRRT) among patients with high-bleeding risk. However, the optimal blood flow rate (BFR) to maximize...
Understanding the influence of marine nutrients on insectivorous and herbivorous reptiles in the Gulf of California islands
Marine subsidies in the extremely arid islands of the northern Gulf of California have been shown to be important enhancing primary productivity and fueling the terrestrial food webs. This effect has...
Targeting the cyclin D/CDK4 Axis to unlock new therapeutic approaches to enhance cancer treatment
Dysregulation of the cyclin D/CDK complex is a common feature in various cancers, including colorectal, breast, and melanoma, leading to uncontrolled tumor growth and cell cycle progression. Targeting...
Determining post-orthognathic surgery profile: A validation study on the potential of modified chin point as a reliable predictor
Objectives To investigate the validity of the modified chin point (MCP) as a reliable predictor for post-orthognathic surgery profile. Materials and methods 136 three-dimensional (3D) facial images...
Is the pay-for-performance program associated with better quality of life among type 2 diabetes patients, including those with gastrointestinal conditions, in Taiwan? A cross-sectional survey
Background Many studies have shown that Taiwan’s diabetes pay-for-performance (P4P) program can improve several patients’ clinical outcomes; however, it remains unclear whether P4P initiatives yield e...
Fetal programming through early weaning shapes the metabotype of Nelore heifers
This study investigated the effects of fetal programming induced by early weaning (EW) of the previous calf on the serum metabotype of Nelore heifers. A 2 × 2 factorial design was employed, considerin...
PLA2R1 and HLA-DQA1 SNP in patients with primary membranous nephropathy
Background Primary membranous nephropathy is a widely recognized autoimmune disease associated with podocyte antigens; the most important autoantigen is PLA2R1. PLA2R1 and HLA-DQA1 play important role...
Global burden of NAFLD 1990–2021 and projections to 2035: Results from the Global Burden of Disease study 2021
Background Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. The global burden of NAFLD is increasing. This study used the Global Burden of Disease (GBD) 2021 study d...
Association of COVID-19 stimulus receipt and spending with family health
In this study, we aimed to determine the impact of U.S. government stimulus payments on family health during the COVID-19 pandemic. We hypothesized that receiving stimulus checks is associated with be...
Multiplex nodal modularity: A novel network metric for the regional analysis of amnestic mild cognitive impairment during a working memory binding task
Modularity is a well-established concept for assessing community structures in various single and multi-layer networks, including those in biological and social domains. Brain networks are known to ex...
Downhill running regulates cardiac immune response through GCN2
Downhill running (DR) has recently emerged as a promising exercise modality for cardiac rehabilitation, but the effect and mechanism of DR on myocardium remains unclear. General control nonderepressib...
Relationship between baseline platelet-to-red blood cell distribution width ratio and all-cause mortality in non-traumatic subarachnoid hemorrhage: A retrospective analysis of the MIMIC-IV database
Objective The study aimed to evaluate the relationship between baseline platelet-to-red blood cell distribution width ratio (PRR) and mortality in critically ill patients with non-traumatic subarachno...
A multi-criteria decision-making framework for managing the safety of marine recreational powered platforms: Integration with the SHELL model
The rise of marine recreational activities has led to a growing use of marine recreational powered platforms, raising safety concerns related to navigation. In Taiwan, the current regulatory system fo...
Structural disorder and distinctive motifs in the C-terminal region of the MADS-domain transcription factors are conserved across diverse taxa
Plants have acquired the ability to adapt and respond to varying environmental conditions through modifications in their developmental programs. This adaptability relies on the plant’s capacity to sen...
Development of a consensus-based core outcome set for post-treatment recovery in adults with epilepsy and comorbid depression or anxiety: A Delphi and ICF-guided protocol
Introduction Up to 50% of adult patients with epilepsy experience comorbid depression or anxiety, complicating post-treatment recovery and requiring tailored outcome assessment. No core outcome set (C...
A 6-month, prospective randomized controlled trial of the TargetEd MAnageMent (TEAM) intervention vs. enhanced treatment as usual among Ugandans at risk for stroke
Background Among low and middle-income countries, especially in Sub-Saharan Africa, the stroke burden is severe, with increasing trends in stroke incidence, prevalence, and mortality. Aims This 6-mo...
Assessing ITN textile preferences: A comparative study of polyethylene and polyester nets across different settings in Burkina Faso
Insecticide-treated nets (ITNs) are crucial for preventing malaria and other vector-borne diseases, effectively reducing transmission and mortality rates. However, their uptake remains low, influenced...
Correction: Enhancing capacitive performance of magnetite-reduced graphene oxide nanocomposites through magnetic field-assisted ion migration
The association between Albumin-Corrected Anion Gap (ACAG) and the risk of acute kidney injury in patients with acute pancreatitis: A retrospective analysis based on the MIMIC-IV database
Purpose Acute kidney injury (AKI), a common and severe complication of acute pancreatitis (AP), is significantly linked to patient prognosis. Albumin-corrected anion gap (ACAG) is a modified acid-base...
Barriers to agricultural employment among African American youth: Evidence from the American Community Survey
This paper investigates the occupational choices of African American youth in U.S. agricultural and food sectors. Using nationally representative data from the American Community Survey, we estimate a...
Operational thresholds of urease-mediated microbial cementation: Multivariate optimization and field validation in ambient groundwater environments
Microbially induced calcium carbonate precipitation (MICP) provides a sustainable method for soil stabilization; however, its practical application is limited by rapid reaction kinetics that cause loc...