Nature Communications
Articles in this Issue
Nuclear effects play an important role in determining codon usage-dependent human gene expression
Ion sensing based on frequency-dependent physico-chemical processes at electrode/electrolyte interfaces
A BRET biosensor for measuring uncompetitive engagement of PRMT5 complexes in cells
Abstract Protein arginine methyl transferase 5 (PRMT5) plays a global role in cell physiology and is an established therapeutic target in cancer. In approximately 10-15% of human can...
Telomere-to-telomere genome assembly of the Dipteran Bactrocera dorsalis from a single individual
A distinct PP2A subunit regulates local protein phosphorylation at the axon initial segment
Enhancing kinase-inhibitor activity and selectivity prediction through contrastive learning
Long-read transcriptomics of a diverse human cohort reveals ancestry bias in gene annotation
Exploiting negative photochromism to harness a four-photon-like fluorescence response with two-photon excitation
Abstract Combining nonlinear optical processes and photoswitching transcends the limitations of conventional and even standalone super-resolution imaging. While photoswitching enable...
TAPB: an interventional debiasing framework for alleviating target prior bias in drug-target interaction prediction
Abstract Drug Target Interaction (DTI) prediction is vital for drug repurposing. Previous DTI studies on BioSNAP and BindingDB datasets often attribute biased pr...
Ratiometric detection of perfluoroalkyl carboxylic acids using dual fluorescent nanoparticles and a miniaturised microfluidic platform
Abstract The widespread contamination of soil and water with perfluoroalkyl substances (PFAS) has caused considerable societal and scientific concern. Legislative measures and an inc...
Structural insights into cauliflower mitoribosome in translation state and in association with a late assembly factor
Abstract Ribosomes are key molecular machines that translate mRNA into proteins. Mitoribosomes are specific ribosomes found in mitochondria, which have been shown to be remarkably di...
Aberrant neural activity in the peritumoral cortex underlies the progression of tumor-associated seizures
Regulated TRESLIN-MTBP loading governs initiation zones and replication timing in human DNA replication
Epigenome-wide association study of nuclear DNA methylation in relation to mitochondrial heteroplasmy
Nuclear actin and DNA replication stress regulate telomere maintenance by telomerase
Identification and characterization of binders to a cryptic and functional pocket in KRAS
Dynamic Organellar Mapping in yeast reveals extensive protein localization changes during ER stress
Abstract Sophisticated techniques are available for systematic studies of yeast cell biology. However, it remains challenging to investigate protein subcellular localization changes...
Large-scale characterisation of the nasal microbiome redefines Staphylococcus aureus colonisation status
Abstract Staphylococcus aureus colonises the nose in humans, with individuals defined as persistent, intermittent or non-carriers. Unlike the...
Altruistic disease signalling in ant colonies
Abstract Sick individuals often conceal their disease status to group members, thereby preventing social exclusion or aggression. Here we show by behavioural, chemical, immunological...
Constitutive activity of an atypical chemokine receptor revealed by inverse agonistic nanobodies
Abstract Stimulation of atypical chemokine receptor 3 (ACKR3) by chemokines does not activate G proteins but recruits arrestin. It is a chemokine scavenger that indirectly influences...
Human pluripotent stem cell-derived skin organoids enabled pathophysiological model of Mycobacterium tuberculosis infection
PolySUMOylation of PCNA and Rad52 restricts centromeric recombination in fission yeast
Abstract SUMOylation, a conserved post-translational modification in eukaryotes, regulates protein function, localization, and stability. However, the role of SU...
A chlorophyll halo over Maud Rise in the Southern Ocean
Abstract Phytoplankton blooms above the seamount Maud Rise in the Antarctic Ocean have been reported but their emerging mechanisms and their importance for the w...
Understanding interspecies drug response variations between human and rodent P2X7 receptors
Identifying hotspots of greenhouse gas emissions from drained peatlands in the European Union
Abstract Greenhouse gas (GHG) emissions from drained peatlands account for about 7% of the total anthropogenic GHG emissions in the European Union (EU). Yet, a l...